ID   ZNF30_HUMAN             Reviewed;         542 AA.
AC   P17039; A8K320; Q6N068;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 3.
DT   05-OCT-2010, entry version 98.
DE   RecName: Full=Zinc finger protein 30;
DE   AltName: Full=Zinc finger protein KOX28;
GN   Name=ZNF30; Synonyms=KOX28;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-42.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-298.
RC   TISSUE=Uterine endothelium;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 403-452.
RC   TISSUE=Lymphoid tissue;
RX   MEDLINE=91145339; PubMed=2288909;
RA   Thiesen H.-J.;
RT   "Multiple genes encoding zinc finger domains are expressed in human T
RT   cells.";
RL   New Biol. 2:363-374(1990).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 18 C2H2-type zinc fingers.
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DR   EMBL; AK290435; BAF83124.1; -; mRNA.
DR   EMBL; BX640666; CAE45802.1; -; mRNA.
DR   EMBL; X52359; CAA36585.1; -; mRNA.
DR   IPI; IPI00942035; -.
DR   PIR; I37968; I37968.
DR   UniGene; Hs.657402; -.
DR   ProteinModelPortal; P17039; -.
DR   Ensembl; ENST00000426813; ENSP00000416457; ENSG00000168661.
DR   GeneCards; GC19P035417; -.
DR   HGNC; HGNC:13090; ZNF30.
DR   HPA; HPA030400; -.
DR   PharmGKB; PA37665; -.
DR   eggNOG; prNOG14092; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; P17039; -.
DR   ArrayExpress; P17039; -.
DR   Bgee; P17039; -.
DR   CleanEx; HS_ZNF30; -.
DR   Genevestigator; P17039; -.
DR   GermOnline; ENSG00000168661; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045449; P:regulation of transcription; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   Pfam; PF00096; zf-C2H2; 9.
DR   SMART; SM00355; ZnF_C2H2; 17.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    542       Zinc finger protein 30.
FT                                /FTId=PRO_0000047359.
FT   ZN_FING      39     61       C2H2-type 1; degenerate.
FT   ZN_FING      67     89       C2H2-type 2.
FT   ZN_FING      95    117       C2H2-type 3; degenerate.
FT   ZN_FING     123    145       C2H2-type 4.
FT   ZN_FING     151    173       C2H2-type 5.
FT   ZN_FING     179    201       C2H2-type 6.
FT   ZN_FING     207    229       C2H2-type 7.
FT   ZN_FING     235    257       C2H2-type 8.
FT   ZN_FING     263    285       C2H2-type 9.
FT   ZN_FING     291    313       C2H2-type 10.
FT   ZN_FING     319    341       C2H2-type 11.
FT   ZN_FING     347    369       C2H2-type 12.
FT   ZN_FING     375    397       C2H2-type 13.
FT   ZN_FING     403    425       C2H2-type 14.
FT   ZN_FING     431    453       C2H2-type 15.
FT   ZN_FING     459    481       C2H2-type 16.
FT   ZN_FING     487    509       C2H2-type 17.
FT   ZN_FING     515    537       C2H2-type 18.
FT   VARIANT      42     42       R -> Q (in dbSNP:rs1811).
FT                                /FTId=VAR_047736.
FT   VARIANT     109    109       A -> T (in dbSNP:rs8100497).
FT                                /FTId=VAR_047737.
FT   VARIANT     298    298       R -> K (in dbSNP:rs1345658).
FT                                /FTId=VAR_047738.
FT   VARIANT     319    319       Y -> C (in dbSNP:rs765746).
FT                                /FTId=VAR_047739.
FT   CONFLICT    112    112       K -> R (in Ref. 2; CAE45802).
FT   CONFLICT    157    157       G -> W (in Ref. 2; CAE45802).
FT   CONFLICT    223    223       A -> V (in Ref. 2; CAE45802).
FT   CONFLICT    412    412       F -> L (in Ref. 2; CAE45802).
SQ   SEQUENCE   542 AA;  61966 MW;  2F7D39C7D1D412D2 CRC64;
     MEPKDLQLED DTIGCKEMPT SENCPSFALH QKISRQKPRE CREYGKTLCQ DSKPVQHERI
     HSSEKPNRCK ECGKNFSNGH QLTIHQRLHV GEKPYKYEKC GKAFISGSAF VKHGRIHTGE
     KPLKCKQCGK TISGSYQLTV HKSIHTGKKP YECGECGKAF LVYGKLTRHQ STHTGEKPFG
     CEECGKAFST FSYLVQHQRI HTSEKPYECK ECGKAFSTSS PLAKHQRIHT GEKPYECKEC
     GKSFTVYGQL TRHQSIHTGE KPFECKECGK AFRLSSFLHA HQRIHAEIKP YGCKECGRTF
     SRASYLVQHG RLHTGEKPYE CKECGKAFST GSYLVQHQRI HTGEKPYECK ECGKAFISRH
     QLTVHQRVHT GEKPYECKEC GKAFRVHVHL TQHRKIHTDV KPYECKECGK TFSRASYLVQ
     HSRIHTGKKP YECKECGKAF SSGSYLVQHQ RIHTGEKPYE CNKCGKAFTV YGQLIGHQSV
     HTGEKPFECK ECGKAFRLNS FLTEHQRVHT GEKPFKCKKC GKTFRYSSAL KVHLRKHMSV
     IP
//