ID   ZNF25_HUMAN             Reviewed;         456 AA.
AC   P17030; A9Z1X5; Q8IYE3; Q8NDD6; Q96MU2;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2003, sequence version 2.
DT   05-OCT-2010, entry version 106.
DE   RecName: Full=Zinc finger protein 25;
DE   AltName: Full=Zinc finger protein KOX19;
GN   Name=ZNF25; Synonyms=KOX19;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Hearn T.;
RT   "Organisation, expression and evolution of Kruppel-type zinc finger
RT   genes in human chromosomal region 10p11.2-q11.2.";
RL   Thesis (2000), University of Newcastle, United Kingdom.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Hippocampus;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-456 (ISOFORM 1), AND
RP   VARIANT LYS-453.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 230-285.
RC   TISSUE=Lymphoid tissue;
RX   MEDLINE=91145339; PubMed=2288909;
RA   Thiesen H.-J.;
RT   "Multiple genes encoding zinc finger domains are expressed in human T
RT   cells.";
RL   New Biol. 2:363-374(1990).
RN   [7]
RP   VARIANTS [LARGE SCALE ANALYSIS] LYS-21 AND GLY-81.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA   Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA   Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA   Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA   Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal
RT   cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P17030-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P17030-2; Sequence=VSP_007846, VSP_007847;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH36038.1; Type=Erroneous initiation;
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DR   EMBL; AJ491696; CAD36955.1; -; mRNA.
DR   EMBL; AK056452; BAB71187.1; -; mRNA.
DR   EMBL; AL834125; CAD38845.1; -; mRNA.
DR   EMBL; AL117337; CAH73314.1; -; Genomic_DNA.
DR   EMBL; BC036038; AAH36038.1; ALT_INIT; mRNA.
DR   EMBL; X52350; CAA36576.1; -; mRNA.
DR   IPI; IPI00412905; -.
DR   IPI; IPI00472052; -.
DR   PIR; I37958; I37958.
DR   RefSeq; NP_659448.1; -.
DR   UniGene; Hs.499429; -.
DR   ProteinModelPortal; P17030; -.
DR   STRING; P17030; -.
DR   PRIDE; P17030; -.
DR   Ensembl; ENST00000302609; ENSP00000302222; ENSG00000175395.
DR   GeneID; 219749; -.
DR   KEGG; hsa:219749; -.
DR   UCSC; uc001ize.1; human.
DR   CTD; 219749; -.
DR   GeneCards; GC10M038278; -.
DR   HGNC; HGNC:13043; ZNF25.
DR   HPA; HPA030190; -.
DR   MIM; 194528; gene.
DR   PharmGKB; PA37621; -.
DR   eggNOG; prNOG05080; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; P17030; -.
DR   OMA; HDLEARY; -.
DR   OrthoDB; EOG9G1Q26; -.
DR   PhylomeDB; P17030; -.
DR   NextBio; 90740; -.
DR   ArrayExpress; P17030; -.
DR   Bgee; P17030; -.
DR   CleanEx; HS_ZNF25; -.
DR   Genevestigator; P17030; -.
DR   GermOnline; ENSG00000175395; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 12.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 8.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 12.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Polymorphism; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    456       Zinc finger protein 25.
FT                                /FTId=PRO_0000047354.
FT   DOMAIN        8     79       KRAB.
FT   ZN_FING     118    140       C2H2-type 1.
FT   ZN_FING     146    168       C2H2-type 2.
FT   ZN_FING     174    196       C2H2-type 3.
FT   ZN_FING     202    224       C2H2-type 4.
FT   ZN_FING     230    252       C2H2-type 5.
FT   ZN_FING     258    280       C2H2-type 6.
FT   ZN_FING     286    308       C2H2-type 7.
FT   ZN_FING     314    336       C2H2-type 8.
FT   ZN_FING     342    364       C2H2-type 9.
FT   ZN_FING     370    392       C2H2-type 10.
FT   ZN_FING     398    420       C2H2-type 11.
FT   ZN_FING     426    448       C2H2-type 12.
FT   VAR_SEQ       1     94       Missing (in isoform 2).
FT                                /FTId=VSP_007846.
FT   VAR_SEQ      95     99       SQAGN -> MWNFL (in isoform 2).
FT                                /FTId=VSP_007847.
FT   VARIANT      21     21       E -> K (in a breast cancer sample;
FT                                somatic mutation).
FT                                /FTId=VAR_035567.
FT   VARIANT      81     81       D -> G (in a breast cancer sample;
FT                                somatic mutation).
FT                                /FTId=VAR_035568.
FT   VARIANT     453    453       N -> K (in dbSNP:rs1208606).
FT                                /FTId=VAR_052748.
SQ   SEQUENCE   456 AA;  53545 MW;  9B65561962CBD85D CRC64;
     MNKFQGPVTL KDVIVEFTKE EWKLLTPAQR TLYKDVMLEN YSHLVSVGYH VNKPNAVFKL
     KQGKEPWILE VEFPHRGFPE DLWSIHDLEA RYQESQAGNS RNGELTKHQK THTTEKACEC
     KECGKFFCQK SALIVHQHTH SKGKSYDCDK CGKSFSKNED LIRHQKIHTR DKTYECKECK
     KIFYHLSSLS RHLRTHAGEK PYECNQCEKS FYQKPHLTEH QKTHTGEKPF ECTECGKFFY
     VKAYLMVHQK THTGEKPYEC KECGKAFSQK SHLTVHQRMH TGEKPYKCKE CGKFFSRNSH
     LKTHQRSHTG EKPYECKECR KCFYQKSALT VHQRTHTGEK PFECNKCGKT FYYKSDLTKH
     QRKHTGEKPY ECTECGKSFA VNSVLRLHQR THTGEKPYAC KECGKSFSQK SHFIIHQRKH
     TGEKPYECQE CGETFIQKSQ LTAHQKTHTK KRNAEK
//