ID   ZNF20_HUMAN             Reviewed;         532 AA.
AC   P17024; Q8N457; Q9UG41;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   05-OCT-2010, entry version 105.
DE   RecName: Full=Zinc finger protein 20;
DE   AltName: Full=Zinc finger protein KOX13;
GN   Name=ZNF20; Synonyms=KOX13;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=B-cell;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 227-282.
RX   MEDLINE=91145339; PubMed=2288909;
RA   Thiesen H.-J.;
RT   "Multiple genes encoding zinc finger domains are expressed in human T
RT   cells.";
RL   New Biol. 2:363-374(1990).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 15 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
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DR   EMBL; AL080125; CAB45723.2; -; mRNA.
DR   EMBL; CH471106; EAW84260.1; -; Genomic_DNA.
DR   EMBL; BC036714; AAH36714.3; -; mRNA.
DR   EMBL; X52344; CAA36570.1; -; mRNA.
DR   IPI; IPI00550953; -.
DR   PIR; T12489; T12489.
DR   RefSeq; NP_066966.2; -.
DR   UniGene; Hs.512823; -.
DR   UniGene; Hs.709334; -.
DR   ProteinModelPortal; P17024; -.
DR   IntAct; P17024; 1.
DR   PRIDE; P17024; -.
DR   Ensembl; ENST00000334213; ENSP00000335437; ENSG00000132010.
DR   GeneID; 7568; -.
DR   KEGG; hsa:7568; -.
DR   UCSC; uc002mtf.1; human.
DR   CTD; 7568; -.
DR   GeneCards; GC19M012241; -.
DR   HGNC; HGNC:12992; ZNF20.
DR   HPA; HPA020887; -.
DR   MIM; 194557; gene.
DR   PharmGKB; PA37572; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; P17024; -.
DR   OrthoDB; EOG9G4KB2; -.
DR   NextBio; 29599; -.
DR   Bgee; P17024; -.
DR   CleanEx; HS_ZNF20; -.
DR   Genevestigator; P17024; -.
DR   GermOnline; ENSG00000132010; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 11.
DR   Pfam; PF01352; KRAB; 1.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 14.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    532       Zinc finger protein 20.
FT                                /FTId=PRO_0000047344.
FT   DOMAIN        7     78       KRAB.
FT   ZN_FING     103    130       C2H2-type 1; atypical.
FT   ZN_FING     143    165       C2H2-type 2; degenerate.
FT   ZN_FING     171    193       C2H2-type 3; degenerate.
FT   ZN_FING     199    221       C2H2-type 4.
FT   ZN_FING     227    249       C2H2-type 5.
FT   ZN_FING     255    277       C2H2-type 6.
FT   ZN_FING     283    305       C2H2-type 7.
FT   ZN_FING     311    333       C2H2-type 8.
FT   ZN_FING     339    361       C2H2-type 9.
FT   ZN_FING     367    389       C2H2-type 10.
FT   ZN_FING     395    417       C2H2-type 11.
FT   ZN_FING     423    445       C2H2-type 12.
FT   ZN_FING     451    473       C2H2-type 13.
FT   ZN_FING     479    500       C2H2-type 14.
FT   ZN_FING     506    528       C2H2-type 15.
SQ   SEQUENCE   532 AA;  61567 MW;  C92473E875FCAA42 CRC64;
     MMFQDSVAFE DVAVSFTQEE WALLDPSQKN LYRDVMQETF KNLTSVGKTW KVQNIEDEYK
     NPRRNLSLMR EKLCESKESH HCGESFNQIA DDMLNRKTLP GITPCESSVC GEVGTGHSSL
     NTHIRADTGH KSSEYQEYGE NPYRNKECKK AFSYLDSFQS HDKACTKEKP YDGKECTETF
     ISHSCIQRHR VMHSGDGPYK CKFCGKAFYF LNLCLIHERI HTGVKPYKCK QCGKAFTRST
     TLPVHERTHT GVNADECKEC GNAFSFPSEI RRHKRSHTGE KPYECKQCGK VFISFSSIQY
     HKMTHTGEKP YECKQCGKAF RCGSHLQKHG RTHTGEKPYE CRQCGKAFRC TSDLQRHEKT
     HTEDKPYGCK QCGKGFRCAS QLQIHERTHS GEKPHECKEC GKVFKYFSSL RIHERTHTGE
     KPHECKQCGK AFRYFSSLHI HERTHTGDKP YECKVCGKAF TCSSSIRYHE RTHTGEKPYE
     CKHCGKAFIS NYIRYHERTH TGEKPYQCKQ CGKAFIRASS CREHERTHTI NR
//