ID   ZN836_HUMAN             Reviewed;         936 AA.
AC   Q6ZNA1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   05-OCT-2010, entry version 55.
DE   RecName: Full=Zinc finger protein 836;
GN   Name=ZNF836;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-891, AND VARIANTS ILE-219
RP   AND SER-809.
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 25 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
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DR   EMBL; AC010320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK131308; BAD18474.1; -; mRNA.
DR   IPI; IPI00784678; -.
DR   RefSeq; NP_001096127.1; -.
DR   UniGene; Hs.631584; -.
DR   HSSP; P17028; 1X6E.
DR   ProteinModelPortal; Q6ZNA1; -.
DR   PRIDE; Q6ZNA1; -.
DR   Ensembl; ENST00000322146; ENSP00000325038; ENSG00000196267.
DR   Ensembl; ENST00000457013; ENSP00000408965; ENSG00000196267.
DR   GeneID; 162962; -.
DR   KEGG; hsa:162962; -.
DR   UCSC; uc002pyo.2; human.
DR   CTD; 162962; -.
DR   GeneCards; GC19M052659; -.
DR   HGNC; HGNC:34333; ZNF836.
DR   eggNOG; prNOG19083; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q6ZNA1; -.
DR   OMA; SILVNHQ; -.
DR   OrthoDB; EOG9PK4VM; -.
DR   NextBio; 88220; -.
DR   ArrayExpress; Q6ZNA1; -.
DR   Bgee; Q6ZNA1; -.
DR   CleanEx; HS_ZNF836; -.
DR   Genevestigator; Q6ZNA1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 24.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 15.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 24.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 24.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 25.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    936       Zinc finger protein 836.
FT                                /FTId=PRO_0000319434.
FT   DOMAIN        8     83       KRAB.
FT   ZN_FING     218    240       C2H2-type 1.
FT   ZN_FING     246    268       C2H2-type 2.
FT   ZN_FING     274    296       C2H2-type 3.
FT   ZN_FING     302    324       C2H2-type 4.
FT   ZN_FING     330    352       C2H2-type 5.
FT   ZN_FING     358    380       C2H2-type 6.
FT   ZN_FING     386    408       C2H2-type 7.
FT   ZN_FING     414    436       C2H2-type 8.
FT   ZN_FING     442    464       C2H2-type 9.
FT   ZN_FING     470    492       C2H2-type 10.
FT   ZN_FING     498    520       C2H2-type 11.
FT   ZN_FING     526    548       C2H2-type 12.
FT   ZN_FING     554    576       C2H2-type 13.
FT   ZN_FING     582    604       C2H2-type 14.
FT   ZN_FING     610    632       C2H2-type 15.
FT   ZN_FING     638    660       C2H2-type 16.
FT   ZN_FING     666    688       C2H2-type 17.
FT   ZN_FING     694    716       C2H2-type 18; degenerate.
FT   ZN_FING     722    744       C2H2-type 19.
FT   ZN_FING     750    772       C2H2-type 20.
FT   ZN_FING     778    800       C2H2-type 21.
FT   ZN_FING     806    828       C2H2-type 22.
FT   ZN_FING     834    856       C2H2-type 23.
FT   ZN_FING     862    884       C2H2-type 24.
FT   ZN_FING     890    912       C2H2-type 25.
FT   VARIANT     219    219       M -> I (in dbSNP:rs1366245).
FT                                /FTId=VAR_039001.
FT   VARIANT     809    809       N -> S (in dbSNP:rs8113504).
FT                                /FTId=VAR_039002.
FT   CONFLICT    434    434       I -> V (in Ref. 2; BAD18474).
FT   CONFLICT    463    463       S -> G (in Ref. 2; BAD18474).
FT   CONFLICT    576    576       H -> R (in Ref. 2; BAD18474).
FT   CONFLICT    661    661       T -> A (in Ref. 2; BAD18474).
SQ   SEQUENCE   936 AA;  107717 MW;  6C7FC8B639550732 CRC64;
     MALTQGPLTF RDVAIEFSQE EWKSLDPVQK ALYWDVMLEN YRNLVFLGIL PKCMTKELPP
     IGNSNTGEKC QTVTLERHEC YDVENFYLRE IQKNLQDLEF QWKDGEINYK EVPMTYKNNL
     NGKRGQHSQE DVENKCIENQ LTLSFQSRLT ELQKFQTEGK IYECNQSEKT VNNSSLVSPL
     QRILPSVQTN ISKKYENEFL QLSLPTQLEK THIREKPYMC KGCGKAFRVS SSLINHQMVH
     TTEKPYKCNE CGKAFHRGSL LTIHQIVHTR GKPYQCGVCG KIFRQNSDLV NHRRSHTGEK
     PYKCNECGKS FSQSYNLAIH QRIHTGEKPY KCNECGKTFK QGSCLTTHQI IHTGEKPYQC
     DICGKVFRQN SNLVNHQRIH TGEKPYKCNI CGKSFSQSSN LATHQTVHSG NKPYKCDECG
     KTFKRSSSLT THQIIHTGEK PYTCDVCDKV FSQRSQLARH QRSHTGEKPY KCNECGKVFS
     QTSHLVGHRR IHTGEKPYKC DKCGKAFKQG SLLTRHKIIH TREKRYQCGE CGKVFSENSC
     LVRHLRIHTG EQPYKCNVCG KVFNYSGNLS IHKRIHTGEK PFQCNECGTV FRNYSCLARH
     LRIHTGQKPY KCNVCGKVFN DSGNLSNHKR IHTGEKPFQC NECGKVFSYY SCLARHRKIH
     TGEKPYKCND CGKAYTQRSS LTKHLIIHTG EKPYNCNEFG GAFIQSSKLA RYHRNPTGEK
     PHKCSHCGRT FSHITGLTYH QRRHTGEMPY KCIECGQVFN STSNLARHRR IHTGEKPYKC
     NECGKVFRHQ STLARHRSIH TGEKPYVCNE CGKAFRVRSI LVNHQKMHTG DKPYKCNECG
     KAFIERSKLV YHQRNHTGEK PYKCIECGKA FGRFSCLNKH QMIHSGEKPY KCNECGKSFI
     SRSGLTKHQT KHTAESLKTK FNVEKPLDVL LTSGFK
//