ID   ZN628_HUMAN             Reviewed;        1048 AA.
AC   Q5EBL2; Q86X34;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   05-OCT-2010, entry version 56.
DE   RecName: Full=Zinc finger protein 628;
GN   Name=ZNF628;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Chondrosarcoma, and Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcription activator. Binds DNA on GT-box consensus
CC       sequence 5'-TTGGTT-3' (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- SIMILARITY: Contains 16 C2H2-type zinc fingers.
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DR   EMBL; BC047332; AAH47332.1; -; mRNA.
DR   EMBL; BC089449; AAH89449.1; -; mRNA.
DR   IPI; IPI00878696; -.
DR   RefSeq; NP_149104.2; -.
DR   UniGene; Hs.525209; -.
DR   ProteinModelPortal; Q5EBL2; -.
DR   SMR; Q5EBL2; 25-103, 50-215, 438-530, 465-581, 522-633.
DR   PRIDE; Q5EBL2; -.
DR   Ensembl; ENST00000357202; ENSP00000365498; ENSG00000197483.
DR   Ensembl; ENST00000391718; ENSP00000375598; ENSG00000197483.
DR   Ensembl; ENST00000448160; ENSP00000399310; ENSG00000197483.
DR   GeneID; 89887; -.
DR   KEGG; hsa:89887; -.
DR   UCSC; uc002qld.2; human.
DR   CTD; 89887; -.
DR   GeneCards; GC19P055987; -.
DR   HGNC; HGNC:28054; ZNF628.
DR   MIM; 610671; gene.
DR   PharmGKB; PA142670507; -.
DR   eggNOG; prNOG17726; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q5EBL2; -.
DR   PhylomeDB; Q5EBL2; -.
DR   NextBio; 76413; -.
DR   ArrayExpress; Q5EBL2; -.
DR   Bgee; Q5EBL2; -.
DR   CleanEx; HS_ZNF628; -.
DR   Genevestigator; Q5EBL2; -.
DR   GermOnline; ENSG00000197483; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 12.
DR   Pfam; PF00096; zf-C2H2; 10.
DR   SMART; SM00355; ZnF_C2H2; 17.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 17.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1   1048       Zinc finger protein 628.
FT                                /FTId=PRO_0000246070.
FT   REPEAT      807    820       1.
FT   REPEAT      821    831       2.
FT   REPEAT      832    842       3.
FT   REPEAT      843    853       4.
FT   ZN_FING      25     47       C2H2-type 1.
FT   ZN_FING      53     75       C2H2-type 2.
FT   ZN_FING      81    103       C2H2-type 3.
FT   ZN_FING     109    131       C2H2-type 4.
FT   ZN_FING     137    159       C2H2-type 5.
FT   ZN_FING     165    187       C2H2-type 6.
FT   ZN_FING     193    215       C2H2-type 7.
FT   ZN_FING     345    367       C2H2-type 8.
FT   ZN_FING     375    397       C2H2-type 9.
FT   ZN_FING     443    465       C2H2-type 10.
FT   ZN_FING     471    493       C2H2-type 11.
FT   ZN_FING     499    521       C2H2-type 12.
FT   ZN_FING     527    549       C2H2-type 13.
FT   ZN_FING     555    577       C2H2-type 14.
FT   ZN_FING     583    605       C2H2-type 15.
FT   ZN_FING     611    633       C2H2-type 16.
FT   REGION      807    853       4 X approximate tandem repeats.
FT   COMPBIAS    219    343       Pro-rich.
FT   COMPBIAS    406    436       Pro-rich.
FT   COMPBIAS    635    729       Pro-rich.
FT   COMPBIAS    740    800       Gly-rich.
SQ   SEQUENCE   1048 AA;  109756 MW;  9C4C4DBFAC064F11 CRC64;
     MAPASTAEGA GEKPGPAAPA PAAQYECGEC GKSFRWSSRL LHHQRTHTGE RPYKCPDCPK
     AFKGSSALLY HQRGHTGERP YQCPDCPKAF KRSSLLQIHR SVHTGLRAFI CGQCGLAFKW
     SSHYQYHLRQ HTGERPYPCP DCPKAFKNSS SLRRHRHVHT GERPYTCGVC GKSFTQSTNL
     RQHQRVHTGE RPFRCPLCPK TFTHSSNLLL HQRTHGAAPA PGAASAAPPP QSREPGKVFV
     CDAYLQRHLQ PHSPPAPPAP PPPPPPVVPE LFLAAAETTV ELVYRCDGCE QGFSSEELLL
     EHQPCPGPDA APQPQEAPAE APKADQPPSP LPQPPPPAAA PAPGFACLPC GKSFRTVAGL
     SRHQHSHGAA GGQAFRCGSC DGSFPQLASL LAHQQCHVEE AAAGRPPPQA EAAEVTCPQE
     PLAPAAPAPP PPPSAPASAE RPYKCAECGK SFKGSSGLRY HLRDHTGERP YQCGECGKAF
     KRSSLLAIHQ RVHTGLRAFT CGQCGLTFKW SSHYQYHLRL HSGERPYACG ECGKAFRNTS
     CLRRHRHVHT GERPHACGVC GKSFAQTSNL RQHQRVHTGE RPFRCPLCPK TFTHSSNLLL
     HQRTHSAERP FTCPICGRGF VMAAYLQRHL RTHAPANTPP STTAPAAGPQ PPAPLAAARA
     PPATQDVHVL PHLQATLSLE VAGGTAQAPS LGPAAPNSQT FLLVQTAQGL QLIPSSVQPP
     TPPPPPAPPK LILLPSSSAG AGGGRARQGP RAVGKAGQGA GVVWLPGPGG LGVQGAASAG
     ASGTGQSLIV LQNVGGGEAG PQEMSGVQLQ PLRPAPEVTT VQLQPAQEVT TVQLQPAQEV
     TTVQLQPAQE VTTVQLQPVA GQLSNSSGGA VATEAPNLLV VQSGAAEELL TGPGPGEAGD
     GEASTGVVQD VLFETLQTDE GLQSVLVLSG ADGEQTRLCV QEVETLPPGL TEPPATGPPG
     QKLLIIRSAP ATELLDSSNT GGGTATLQLL APPPSGPASG PAGLPGAPAS QMVQVVPAGA
     GPGVMTPQGL PSIQIVQTLP AVQLVHTF
//