ID   ZN624_HUMAN             Reviewed;         865 AA.
AC   Q9P2J8; Q3SY62; Q3SY63; Q6ZN27;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 3.
DT   05-OCT-2010, entry version 79.
DE   RecName: Full=Zinc finger protein 624;
GN   Name=ZNF624; Synonyms=KIAA1349;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
RP   ASN-135.
RC   TISSUE=Brain;
RX   MEDLINE=20181126; PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA   Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XVI.
RT   The complete sequences of 150 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 7:65-73(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP   ASN-135.
RC   TISSUE=Tongue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   VARIANT [LARGE SCALE ANALYSIS] SER-558.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA   Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA   Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA   Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA   Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal
RT   cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9P2J8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9P2J8-2; Sequence=VSP_037538;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 21 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA92587.1; Type=Erroneous initiation;
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AB037770; BAA92587.1; ALT_INIT; mRNA.
DR   EMBL; AK131401; BAD18548.1; -; mRNA.
DR   EMBL; AC092714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC098850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC103943; AAI03944.1; -; mRNA.
DR   EMBL; BC103944; AAI03945.1; -; mRNA.
DR   EMBL; BC103946; AAI03947.1; -; mRNA.
DR   IPI; IPI00412544; -.
DR   IPI; IPI00930252; -.
DR   RefSeq; NP_065838.2; -.
DR   UniGene; Hs.128078; -.
DR   ProteinModelPortal; Q9P2J8; -.
DR   PRIDE; Q9P2J8; -.
DR   Ensembl; ENST00000311331; ENSP00000310472; ENSG00000197566.
DR   GeneID; 57547; -.
DR   KEGG; hsa:57547; -.
DR   CTD; 57547; -.
DR   GeneCards; GC17M016464; -.
DR   HGNC; HGNC:29254; ZNF624.
DR   PharmGKB; PA134977006; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q9P2J8; -.
DR   OMA; KPYKCYD; -.
DR   OrthoDB; EOG9ZCWPM; -.
DR   PhylomeDB; Q9P2J8; -.
DR   ArrayExpress; Q9P2J8; -.
DR   Bgee; Q9P2J8; -.
DR   CleanEx; HS_ZNF624; -.
DR   Genevestigator; Q9P2J8; -.
DR   GermOnline; ENSG00000197566; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 21.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 14.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 21.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 20.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 21.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Polymorphism; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    865       Zinc finger protein 624.
FT                                /FTId=PRO_0000047695.
FT   DOMAIN       54    125       KRAB.
FT   ZN_FING     276    298       C2H2-type 1.
FT   ZN_FING     304    326       C2H2-type 2.
FT   ZN_FING     332    354       C2H2-type 3.
FT   ZN_FING     360    382       C2H2-type 4; degenerate.
FT   ZN_FING     388    410       C2H2-type 5.
FT   ZN_FING     416    438       C2H2-type 6.
FT   ZN_FING     444    466       C2H2-type 7.
FT   ZN_FING     472    494       C2H2-type 8.
FT   ZN_FING     500    522       C2H2-type 9.
FT   ZN_FING     528    550       C2H2-type 10.
FT   ZN_FING     556    578       C2H2-type 11.
FT   ZN_FING     584    606       C2H2-type 12.
FT   ZN_FING     612    634       C2H2-type 13.
FT   ZN_FING     640    662       C2H2-type 14.
FT   ZN_FING     668    690       C2H2-type 15.
FT   ZN_FING     696    718       C2H2-type 16.
FT   ZN_FING     724    746       C2H2-type 17.
FT   ZN_FING     752    774       C2H2-type 18.
FT   ZN_FING     780    802       C2H2-type 19.
FT   ZN_FING     808    830       C2H2-type 20.
FT   ZN_FING     836    858       C2H2-type 21.
FT   VAR_SEQ       1    126       Missing (in isoform 2).
FT                                /FTId=VSP_037538.
FT   VARIANT     135    135       K -> N (in dbSNP:rs8065506).
FT                                /FTId=VAR_058001.
FT   VARIANT     558    558       C -> S (in a colorectal cancer sample;
FT                                somatic mutation).
FT                                /FTId=VAR_035592.
FT   CONFLICT    576    576       R -> C (in Ref. 2; BAD18548).
FT   CONFLICT    747    747       S -> T (in Ref. 4; AAI03947).
SQ   SEQUENCE   865 AA;  99929 MW;  12BB2E9410FFF91F CRC64;
     MSLQDSTLSR EGKPEGEIMA AVFFSVGRLS PEVTQPDEDL HLQAEETQLV KESVTFKDVA
     IDFTLEEWRL MDPTQRNLHK DVMLENYRNL VSLGLAVSKP DMISHLENGK GPWVTVREIS
     RIPYPDMEPK PATKKATRTK AISEDLSQEA ILEKLTENGL WDSRMEGLWK WNDRILRLQN
     NQENHLSQRI IPLKKTPTSQ RGFRFESILI PEPGIATEEL HSRCQTQEEN FTENLNLITD
     THLGKIICKE MKGSKAIRQT SELTLGKKSN NKEKPYKCST CEKAFHYRSL LIQHQRTHTK
     EKPYECNECG KTFSQPSYLS QHKKIHTGEK PYKCNECGKA FIASSSLMVH QRIHTKEKPY
     QCNVCGKSFS QCARLNQHQR IQTGEKPYKC SECGKAFSDK SKLARHQETH NGEKPYKCDD
     CGKAFRNKSY LSVHQKTHTE EKPYQCNECG KSFKNTTIFN VHQRIHTGEK PFRCNECGKA
     YRSNSSLIVH IRTHTGEKPY ECNECGKAFN RIANFTEHQR IHTGEKPYKC NECGKAFINY
     SCLTVHHRMH TGEKPYKCTE CGKAFMRSSS LIIHQRIHTE EKPYLCNECG ESFRIKSHLT
     VHQRIHTGEK PYKCTDCERA FTKMVNLKEH QKIHTGVKPY KCYDCGKSFR TKSYLIVHQR
     THTGEKPYKC NECEKAFTNT SQLTVHQRRH TGEKPYKCNE CGKVFTSNSG FNTHQRTHTG
     EKPFKCNDCG KAFSQMVHVT EHQKIHSGEK PYKCDVCGKA FRRGSYLTVH WRTHTGEKPY
     TCKECGKGCI TLSQLTLHQR IHTGERPYKC EECGKAFRTN SDFTVHLRMH TGEKPYKCNE
     CGKAFRSSSS LTVHQRIHQR ETQLI
//