ID   ZN620_HUMAN             Reviewed;         422 AA.
AC   Q6ZNG0; Q8N223;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   05-OCT-2010, entry version 55.
DE   RecName: Full=Zinc finger protein 620;
GN   Name=ZNF620;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Amygdala, and Thymus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6ZNG0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZNG0-2; Sequence=VSP_016040;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 8 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
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DR   EMBL; AK093599; BAC04203.1; -; mRNA.
DR   EMBL; AK131232; BAD18415.1; -; mRNA.
DR   IPI; IPI00166247; -.
DR   IPI; IPI00654765; -.
DR   RefSeq; NP_787084.1; -.
DR   UniGene; Hs.581541; -.
DR   ProteinModelPortal; Q6ZNG0; -.
DR   SMR; Q6ZNG0; 7-57, 219-330, 246-363, 274-391, 361-415.
DR   PRIDE; Q6ZNG0; -.
DR   Ensembl; ENST00000314529; ENSP00000322265; ENSG00000177842.
DR   GeneID; 253639; -.
DR   KEGG; hsa:253639; -.
DR   UCSC; uc003ckk.1; human.
DR   UCSC; uc003ckl.1; human.
DR   CTD; 253639; -.
DR   GeneCards; GC03P040522; -.
DR   HGNC; HGNC:28742; ZNF620.
DR   HPA; HPA031452; -.
DR   PharmGKB; PA134942360; -.
DR   eggNOG; prNOG19321; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q6ZNG0; -.
DR   OMA; SWCGRFI; -.
DR   NextBio; 92139; -.
DR   Bgee; Q6ZNG0; -.
DR   CleanEx; HS_ZNF620; -.
DR   Genevestigator; Q6ZNG0; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 8.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 8.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    422       Zinc finger protein 620.
FT                                /FTId=PRO_0000047691.
FT   DOMAIN       11     82       KRAB.
FT   ZN_FING     196    218       C2H2-type 1.
FT   ZN_FING     224    246       C2H2-type 2.
FT   ZN_FING     252    274       C2H2-type 3.
FT   ZN_FING     280    302       C2H2-type 4.
FT   ZN_FING     308    330       C2H2-type 5.
FT   ZN_FING     336    358       C2H2-type 6.
FT   ZN_FING     364    386       C2H2-type 7.
FT   ZN_FING     392    414       C2H2-type 8.
FT   VAR_SEQ       1    114       Missing (in isoform 2).
FT                                /FTId=VSP_016040.
SQ   SEQUENCE   422 AA;  48503 MW;  25F673810C3A1923 CRC64;
     MFQTAWRQEP VTFEDVAVYF TQNEWASLDS VQRALYREVM LENYANVASL AFPFTTPVLV
     SQLEQGELPW GLDPWEPMGR EALRGICPGD EARTEKEGLT PKDHVSKETE SFRLMVGGLP
     GNVSQHLDFG SSLEQPQGHW IIKTKSKRRH FTDTSARHHE AYEVKNGEKF EKLGKNISVS
     TQLTTNQTNP SGQISYECGQ CGRYFIQMAD FHRHEKCHTG EKSFECKECG KYFRYNSLLI
     RHQIIHTGKK PFKCKECGKG LSSDTALIQH QRIHTGEKPY ECKECGKAFS SSSVFLQHQR
     FHTGEKLYEC NECWKTFSCS SSFTVHQRMH TGEKPYECKE CGKRLSSNTA LTQHQRIHTG
     EKPFECKECG KAFNQKITLI QHQRVHTGEK PYECKVCGKT FSWCGRFILH QKLHTQKTPV
     QA
//