ID   ZN566_HUMAN             Reviewed;         418 AA.
AC   Q969W8; Q2M3J1;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   05-OCT-2010, entry version 70.
DE   RecName: Full=Zinc finger protein 566;
GN   Name=ZNF566;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Urinary bladder;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 8 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
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DR   EMBL; AK027685; BAB55296.1; -; mRNA.
DR   EMBL; BC007064; AAH07064.1; -; mRNA.
DR   EMBL; BC104886; AAI04887.1; -; mRNA.
DR   EMBL; BC104888; AAI04889.1; -; mRNA.
DR   IPI; IPI00396149; -.
DR   RefSeq; NP_001138816.1; -.
DR   RefSeq; NP_001138817.1; -.
DR   RefSeq; NP_116227.1; -.
DR   UniGene; Hs.533939; -.
DR   ProteinModelPortal; Q969W8; -.
DR   SMR; Q969W8; 2-54, 196-363, 252-391.
DR   PRIDE; Q969W8; -.
DR   Ensembl; ENST00000358744; ENSP00000351594; ENSG00000186017.
DR   Ensembl; ENST00000424129; ENSP00000401259; ENSG00000186017.
DR   Ensembl; ENST00000434377; ENSP00000415520; ENSG00000186017.
DR   GeneID; 84924; -.
DR   UCSC; uc002oea.2; human.
DR   CTD; 84924; -.
DR   GeneCards; GC19M036936; -.
DR   HGNC; HGNC:25919; ZNF566.
DR   HPA; HPA023456; -.
DR   PharmGKB; PA134977695; -.
DR   eggNOG; prNOG04574; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q969W8; -.
DR   OrthoDB; EOG9T1M6X; -.
DR   PhylomeDB; Q969W8; -.
DR   NextBio; 75342; -.
DR   ArrayExpress; Q969W8; -.
DR   Bgee; Q969W8; -.
DR   CleanEx; HS_ZNF566; -.
DR   Genevestigator; Q969W8; -.
DR   GermOnline; ENSG00000186017; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 7.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 6.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 7.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    418       Zinc finger protein 566.
FT                                /FTId=PRO_0000047656.
FT   DOMAIN        6     77       KRAB.
FT   ZN_FING     169    193       C2H2-type 1; degenerate.
FT   ZN_FING     199    221       C2H2-type 2.
FT   ZN_FING     227    249       C2H2-type 3.
FT   ZN_FING     255    277       C2H2-type 4.
FT   ZN_FING     283    395       C2H2-type 5.
FT   ZN_FING     311    333       C2H2-type 6.
FT   ZN_FING     339    361       C2H2-type 7.
FT   ZN_FING     367    389       C2H2-type 8.
SQ   SEQUENCE   418 AA;  49219 MW;  619047F0565141C2 CRC64;
     MAQESVMFSD VSVDFSQEEW ECLNDDQRDL YRDVMLENYS NLVSMGHSIS KPNVISYLEQ
     GKEPWLADRE LTRGQWPVLE SRCETKKLFL KKEIYEIEST QWEIMEKLTR RDFQCSSFRD
     DWECNRQFKK ELGSQGGHFN QLVFTHEDLP TLSHHPSFTL QQIINSKKKF CASKEYRKTF
     RHGSQFATHE IIHTIEKPYE CKECGKSFRH PSRLTHHQKI HTGKKPFECK ECGKTFICGS
     DLTRHHRIHT GEKPYECKEC GKAFSSGSNF TRHQRIHTGE KPYECKECGK AFSSGSNFTQ
     HQRIHTGEKP YECKECGNAF SQSSQLIKHQ RIHTGEKPYE CKECEKAFRS GSDLTRHQRI
     HTGEKPYECK ICGKAYSQSS QLISHHRIHT SEKPYEYREC GKNFNYDPQL IQHQNLYW
//