ID   ZN563_HUMAN             Reviewed;         476 AA.
AC   Q8TA94; B2R9E7; Q8NAT7;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   05-OCT-2010, entry version 71.
DE   RecName: Full=Zinc finger protein 563;
GN   Name=ZNF563;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Spleen;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8TA94-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8TA94-2; Sequence=VSP_016381, VSP_016382;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
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DR   EMBL; AK092116; BAC03810.1; -; mRNA.
DR   EMBL; AK313755; BAG36494.1; -; mRNA.
DR   EMBL; CH471106; EAW84268.1; -; Genomic_DNA.
DR   EMBL; BC022523; AAH22523.1; -; mRNA.
DR   IPI; IPI00179899; -.
DR   IPI; IPI00184499; -.
DR   RefSeq; NP_660319.1; -.
DR   UniGene; Hs.663510; -.
DR   ProteinModelPortal; Q8TA94; -.
DR   SMR; Q8TA94; 1-59, 167-333, 195-361, 248-389, 414-445.
DR   PRIDE; Q8TA94; -.
DR   Ensembl; ENST00000293725; ENSP00000293725; ENSG00000188868.
DR   GeneID; 147837; -.
DR   KEGG; hsa:147837; -.
DR   UCSC; uc002mtp.1; human.
DR   UCSC; uc002mtq.1; human.
DR   CTD; 147837; -.
DR   GeneCards; GC19M012429; -.
DR   HGNC; HGNC:30498; ZNF563.
DR   PharmGKB; PA134949077; -.
DR   eggNOG; prNOG14153; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q8TA94; -.
DR   OMA; PSVCQRH; -.
DR   OrthoDB; EOG9G4KB2; -.
DR   PhylomeDB; Q8TA94; -.
DR   NextBio; 85743; -.
DR   ArrayExpress; Q8TA94; -.
DR   Bgee; Q8TA94; -.
DR   CleanEx; HS_ZNF563; -.
DR   Genevestigator; Q8TA94; -.
DR   GermOnline; ENSG00000188868; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 8.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    476       Zinc finger protein 563.
FT                                /FTId=PRO_0000047653.
FT   DOMAIN        4     96       KRAB.
FT   ZN_FING     101    125       C2H2-type 1; degenerate.
FT   ZN_FING     169    191       C2H2-type 2; degenerate.
FT   ZN_FING     197    219       C2H2-type 3.
FT   ZN_FING     225    247       C2H2-type 4.
FT   ZN_FING     253    275       C2H2-type 5.
FT   ZN_FING     281    303       C2H2-type 6.
FT   ZN_FING     309    331       C2H2-type 7.
FT   ZN_FING     337    359       C2H2-type 8.
FT   ZN_FING     365    387       C2H2-type 9.
FT   ZN_FING     393    415       C2H2-type 10.
FT   ZN_FING     421    443       C2H2-type 11.
FT   ZN_FING     449    471       C2H2-type 12.
FT   VAR_SEQ     199    229       CKLCGKAFFWPSLLRMHERTHTGEKPYECKQ -> FPIEDM
FT                                RECTLGRNRMNVSSVLKPCLIPVP (in isoform 2).
FT                                /FTId=VSP_016381.
FT   VAR_SEQ     230    476       Missing (in isoform 2).
FT                                /FTId=VSP_016382.
SQ   SEQUENCE   476 AA;  55434 MW;  02F71928C37166B2 CRC64;
     MDAVAFEDVA VNFTQEEWAL LGPSQKNLYR YVMQETIRNL DCIRMIWEEQ NTEDQYKNPR
     RNLRCHMVER FSESKDSSQC GETFSLIRDS IVNNSICPGE DPCQSAECEE VIMGHLSLNS
     HIRVDSGHKP HEYQEYGEKP HTHKQRGKAF SYHHSFQSRG RPHTGKKRYE CKECGKTFSS
     RRNLRRHMVV QGGNRPYKCK LCGKAFFWPS LLRMHERTHT GEKPYECKQC SKAFPFYSSY
     RRHERMHTGE KPYECKQCSK ALPDSSSYIR HERTHTGEKP YTCKQCGKAF SVSSSLRRHE
     TTHSAEKPYE CKQCGKTFHH LGSFQIHMKR HTGDRPHKCK ICGKGFDRPS LVRYHERIHT
     GEKPYECKQC GKTLSHSSSF RRHMIMHTGG GPHKCKICGK AFVYPSVCQR HEKSHSGEKP
     YECKQCGKAL SHSSSFRRHM VMHTGDGPNK CKVCGKAFVY PSVCQRHEKT HWRETI
//