ID   ZN529_HUMAN             Reviewed;         530 AA.
AC   Q6P280; Q9H731; Q9HCF7;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   05-OCT-2010, entry version 66.
DE   RecName: Full=Zinc finger protein 529;
GN   Name=ZNF529; Synonyms=KIAA1615;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
RP   LEU-98.
RC   TISSUE=Colon;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-530 (ISOFORM 1).
RC   TISSUE=Brain;
RX   MEDLINE=20450683; PubMed=10997877; DOI=10.1093/dnares/7.4.271;
RA   Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes.
RT   XVIII. The complete sequences of 100 new cDNA clones from brain which
RT   code for large proteins in vitro.";
RL   DNA Res. 7:273-281(2000).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6P280-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6P280-2; Sequence=VSP_023663;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AK025110; BAB15068.1; -; mRNA.
DR   EMBL; BC064690; AAH64690.1; -; mRNA.
DR   EMBL; AB046835; BAB13441.1; -; mRNA.
DR   IPI; IPI00829603; -.
DR   IPI; IPI00923572; -.
DR   RefSeq; NP_066002.3; -.
DR   UniGene; Hs.724565; -.
DR   HSSP; P17028; 1X6E.
DR   ProteinModelPortal; Q6P280; -.
DR   SMR; Q6P280; 2-49, 274-355, 302-469, 359-496, 442-517.
DR   PRIDE; Q6P280; -.
DR   Ensembl; ENST00000334116; ENSP00000334695; ENSG00000186020.
DR   Ensembl; ENST00000396897; ENSP00000380106; ENSG00000186020.
DR   GeneID; 57711; -.
DR   UCSC; uc002oeg.2; human.
DR   CTD; 57711; -.
DR   GeneCards; GC19M037034; -.
DR   HGNC; HGNC:29328; ZNF529.
DR   HPA; HPA031311; -.
DR   PharmGKB; PA134910867; -.
DR   eggNOG; prNOG19718; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q6P280; -.
DR   NextBio; 64620; -.
DR   ArrayExpress; Q6P280; -.
DR   Bgee; Q6P280; -.
DR   CleanEx; HS_ZNF529; -.
DR   Genevestigator; Q6P280; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 9.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 9.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Polymorphism; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    530       Zinc finger protein 529.
FT                                /FTId=PRO_0000280419.
FT   DOMAIN        6     86       KRAB.
FT   ZN_FING     166    188       C2H2-type 1; degenerate.
FT   ZN_FING     221    243       C2H2-type 2; degenerate.
FT   ZN_FING     249    271       C2H2-type 3.
FT   ZN_FING     277    299       C2H2-type 4.
FT   ZN_FING     305    327       C2H2-type 5.
FT   ZN_FING     333    355       C2H2-type 6.
FT   ZN_FING     361    383       C2H2-type 7.
FT   ZN_FING     389    411       C2H2-type 8.
FT   ZN_FING     417    439       C2H2-type 9.
FT   ZN_FING     445    467       C2H2-type 10.
FT   ZN_FING     473    495       C2H2-type 11.
FT   ZN_FING     501    523       C2H2-type 12; degenerate.
FT   VAR_SEQ       1     72       Missing (in isoform 2).
FT                                /FTId=VSP_023663.
FT   VARIANT      98     98       V -> L (in dbSNP:rs2912444).
FT                                /FTId=VAR_031147.
FT   CONFLICT     68     68       P -> S (in Ref. 2; BAB13441).
SQ   SEQUENCE   530 AA;  62249 MW;  E532CB5604C7C36D CRC64;
     MDHELVTLRD VVINFSQEEW EYLDSAQRNL YWDVMMENYS NLLSLDLESR NETKHLSVGK
     DIIQNTGPQW EVMESSKLCG LEGSIFRNDW QSKSKIDVQG PEVGYFSQMK IISENVPSYK
     THESLTLPRR THDSEKPYEY KEYEKVFSCD LEFDEYQKIH TGGKNYECNQ CWKTFGIDNS
     SMLQLNIHTG VKPCKYMEYG NTCSFYKDFN VYQKIHNEKF YKCKEYRRTF ERVGKVTPLQ
     RVHDGEKHFE CSFCGKSFRV HAQLTRHQKI HTDEKTYKCM ECGKDFRFHS QLTEHQRIHT
     GEKPYKCMHC EKVFRISSQL IEHQRIHTGE KPYACKECGK AFGVCRELAR HQRIHTGKKP
     YECKACGKVF RNSSSLTRHQ RIHTGEKPYK CKECEKAFGV GSELTRHERI HSGQKPYECK
     ECGKFFRLTS ALIQHQRIHS GEKPYECKVC GKAFRHSSAL TEHQRIHTGE KPYECKACGK
     AFRHSSSFTK HQRIHTDDKP YECKECGNSF SVVGHLTCQP KIYTGEKSFD
//