ID   ZN519_HUMAN             Reviewed;         540 AA.
AC   Q8TB69;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   05-OCT-2010, entry version 66.
DE   RecName: Full=Zinc finger protein 519;
GN   Name=ZNF519;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA   Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA   Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA   Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA   Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA   Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA   O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA   Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA   Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-206.
RC   TISSUE=Prostatic adenocarcinoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 10 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
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DR   EMBL; AC006557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC024227; AAH24227.1; -; mRNA.
DR   IPI; IPI00152143; -.
DR   RefSeq; NP_660330.2; -.
DR   UniGene; Hs.352635; -.
DR   ProteinModelPortal; Q8TB69; -.
DR   SMR; Q8TB69; 1-44, 289-456, 373-512, 402-540.
DR   STRING; Q8TB69; -.
DR   PRIDE; Q8TB69; -.
DR   Ensembl; ENST00000309305; ENSP00000307908; ENSG00000175322.
DR   GeneID; 162655; -.
DR   KEGG; hsa:162655; -.
DR   UCSC; uc002kst.1; human.
DR   CTD; 162655; -.
DR   GeneCards; GC18M014094; -.
DR   HGNC; HGNC:30574; ZNF519.
DR   HPA; HPA028982; -.
DR   PharmGKB; PA134863605; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q8TB69; -.
DR   PhylomeDB; Q8TB69; -.
DR   NextBio; 88206; -.
DR   ArrayExpress; Q8TB69; -.
DR   CleanEx; HS_ZNF519; -.
DR   Genevestigator; Q8TB69; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 9.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 9.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 10.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    540       Zinc finger protein 519.
FT                                /FTId=PRO_0000047637.
FT   DOMAIN        4     78       KRAB.
FT   ZN_FING     181    203       C2H2-type 1; degenerate.
FT   ZN_FING     292    314       C2H2-type 2.
FT   ZN_FING     320    342       C2H2-type 3.
FT   ZN_FING     348    370       C2H2-type 4.
FT   ZN_FING     376    398       C2H2-type 5.
FT   ZN_FING     404    426       C2H2-type 6.
FT   ZN_FING     432    454       C2H2-type 7.
FT   ZN_FING     460    482       C2H2-type 8.
FT   ZN_FING     488    510       C2H2-type 9.
FT   ZN_FING     516    538       C2H2-type 10.
FT   VARIANT      18     18       W -> R (in dbSNP:rs16941623).
FT                                /FTId=VAR_052854.
FT   VARIANT      89     89       G -> S (in dbSNP:rs10221432).
FT                                /FTId=VAR_052855.
FT   VARIANT     206    206       K -> E (in dbSNP:rs2159940).
FT                                /FTId=VAR_052856.
FT   VARIANT     229    229       R -> I (in dbSNP:rs8094412).
FT                                /FTId=VAR_052857.
FT   CONFLICT    167    167       N -> D (in Ref. 2; AAH24227).
SQ   SEQUENCE   540 AA;  63020 MW;  D3212C320B418C3C CRC64;
     MELLTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL VSLAVYSYYN QGILPEQGIQ
     DSFKKATLGR YGSCGLENIC LWKNWESIGE GEGQKECYNL CSQYLTTSHN KHLTVKGDKE
     YRIFQKKPQF LSAAPTEPCI PMNKYQHKFL KSVFCNKNQI NFNHDSNISK HHSTHFLENY
     YNCNECEKVF YQSSKLIFPE NIHIQKKPYN SNECGETSDP FSKLTQHQRI YIGESSQRCN
     KKCIIVFSQS HLKGHKIINT GEKSVKYKER GKAFTRGLHL GHQKIHTGEK PYKCKKCDKA
     FNKSSHLAQH QRIHTGEKPF KCKECGKAFN RGSYLTQHQR IHTGERAFKC EECGKAFNRG
     SYLTQHQRIH TGEKPFRCKE CGKAFNRSSY VTQHQRMHTG EKPFKCKECG KAFNRASHLT
     QHQRIHTGEK HFKCKECGKA FNRGSHLTRH QRIHTGEKSF KCEECGKAFI WGSHLTQHQR
     VHTGEKFFKC KECGKAFTRS SHLTQHQRIH TGEKPFKCKE CGKAFNRRST LTQHQIIHTR
//