ID   ZN510_HUMAN             Reviewed;         683 AA.
AC   Q9Y2H8;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   05-OCT-2010, entry version 90.
DE   RecName: Full=Zinc finger protein 510;
GN   Name=ZNF510; Synonyms=KIAA0972;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=99246063; PubMed=10231032; DOI=10.1093/dnares/6.1.63;
RA   Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M.,
RA   Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XIII.
RT   The complete sequences of 100 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 6:63-70(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-467.
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 10 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA76816.2; Type=Erroneous initiation;
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DR   EMBL; AB023189; BAA76816.2; ALT_INIT; mRNA.
DR   EMBL; BC058022; AAH58022.1; ALT_TERM; mRNA.
DR   IPI; IPI00007234; -.
DR   RefSeq; NP_055745.1; -.
DR   UniGene; Hs.75264; -.
DR   ProteinModelPortal; Q9Y2H8; -.
DR   MINT; MINT-1187569; -.
DR   PhosphoSite; Q9Y2H8; -.
DR   PRIDE; Q9Y2H8; -.
DR   Ensembl; ENST00000223428; ENSP00000223428; ENSG00000081386.
DR   Ensembl; ENST00000375231; ENSP00000364379; ENSG00000081386.
DR   Ensembl; ENST00000449952; ENSP00000406580; ENSG00000081386.
DR   GeneID; 22869; -.
DR   KEGG; hsa:22869; -.
DR   UCSC; uc004awn.1; human.
DR   CTD; 22869; -.
DR   GeneCards; GC09M099518; -.
DR   HGNC; HGNC:29161; ZNF510.
DR   PharmGKB; PA134944603; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q9Y2H8; -.
DR   OMA; WRKDHLI; -.
DR   OrthoDB; EOG91ZHWZ; -.
DR   PhylomeDB; Q9Y2H8; -.
DR   NextBio; 43395; -.
DR   ArrayExpress; Q9Y2H8; -.
DR   Bgee; Q9Y2H8; -.
DR   CleanEx; HS_ZNF510; -.
DR   Genevestigator; Q9Y2H8; -.
DR   GermOnline; ENSG00000081386; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 9.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 7.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 10.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    683       Zinc finger protein 510.
FT                                /FTId=PRO_0000047628.
FT   DOMAIN       46    117       KRAB.
FT   ZN_FING     254    276       C2H2-type 1; degenerate.
FT   ZN_FING     404    426       C2H2-type 2.
FT   ZN_FING     432    454       C2H2-type 3.
FT   ZN_FING     460    482       C2H2-type 4.
FT   ZN_FING     488    510       C2H2-type 5.
FT   ZN_FING     516    538       C2H2-type 6.
FT   ZN_FING     544    566       C2H2-type 7.
FT   ZN_FING     572    594       C2H2-type 8.
FT   ZN_FING     600    622       C2H2-type 9.
FT   ZN_FING     628    650       C2H2-type 10.
FT   VARIANT      43     43       Q -> R (in dbSNP:rs2289651).
FT                                /FTId=VAR_019982.
FT   VARIANT      89     89       C -> R (in dbSNP:rs3780548).
FT                                /FTId=VAR_021893.
FT   VARIANT     273    273       N -> K (in dbSNP:rs10217154).
FT                                /FTId=VAR_052848.
FT   VARIANT     398    398       H -> D (in dbSNP:rs11999094).
FT                                /FTId=VAR_052849.
FT   VARIANT     401    401       M -> I (in dbSNP:rs10217494).
FT                                /FTId=VAR_052850.
FT   VARIANT     634    634       G -> E (in dbSNP:rs10119874).
FT                                /FTId=VAR_052851.
SQ   SEQUENCE   683 AA;  79142 MW;  A87DB365993EE3F3 CRC64;
     MSPHPEAITD CVTLNTVGQL AEGGYPLRFS TLFQEQQKMN ISQASVSFKD VTIEFTQEEW
     QQMAPVQKNL YRDVMLENYS NLVSVGYCCF KPEVIFKLEQ GEEPWFSEEE FSNQSHPKDY
     RGDDLIKQNK KIKDKHLEQA ICINNKTLTT EEEKVLGKPF TLHVAAVAST KMSCKCNSWE
     VNLQSISEFI INNRNYSTKK IGCGNVCENS PFKINFEKTQ TGEKFYEHNK NMKALNYNEN
     LPKHPKFQTL EQAFECNKIG KAFNDKANCV KHNSSHTGET SSKDDEFRKN CDKKTLFDHR
     RTGTGKKHLH LNQCGKSFEK STVEEYNKLN MGIKHYELNP SGNNFNRKAH LTDPQTAVIE
     ENPLVSNDRT QTWVKSSEYH ENKKSYQTSV HRVRRRSHSM MKPYKCNECG KSFCQKGHLI
     QHQRTHTGEK PFECSECGKT FSQKSHLSTH QRIHTAEKPY KCNECGKTFV QKSTLRGHQR
     IHTGEKPYEC SECGKTFVQK STLRDHHRIH TGEKSFQCNQ CGKTFGQKSN LRIHQRTHTG
     EKTYQCNECE KSFWRKDHLI QHQKTHTGEK PFKCNECGKT FARTSTLRVH QRIHTGEKPF
     KCNECGKKFV RKAILSDHQR IHTGEKPFQC NKCGKTFGQK SNLRIHQRTH SGEKSYECNE
     YGKLCKKSTL SLYQKIQGEG NPY
//