ID   ZN485_HUMAN             Reviewed;         441 AA.
AC   Q8NCK3; Q96CL0;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   05-OCT-2010, entry version 68.
DE   RecName: Full=Zinc finger protein 485;
GN   Name=ZNF485;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 11 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH14161.1; Type=Frameshift; Positions=3;
CC       Sequence=CAH73487.1; Type=Erroneous gene model prediction;
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AK074679; BAC11133.1; -; mRNA.
DR   EMBL; AL645634; CAH73487.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC014161; AAH14161.1; ALT_FRAME; mRNA.
DR   IPI; IPI00412024; -.
DR   RefSeq; NP_660355.2; -.
DR   UniGene; Hs.147440; -.
DR   ProteinModelPortal; Q8NCK3; -.
DR   SMR; Q8NCK3; 5-58, 209-324, 239-406, 292-436.
DR   PRIDE; Q8NCK3; -.
DR   Ensembl; ENST00000361807; ENSP00000354694; ENSG00000198298.
DR   Ensembl; ENST00000374435; ENSP00000363558; ENSG00000198298.
DR   GeneID; 220992; -.
DR   KEGG; hsa:220992; -.
DR   CTD; 220992; -.
DR   GeneCards; GC10P044101; -.
DR   HGNC; HGNC:23440; ZNF485.
DR   PharmGKB; PA134887005; -.
DR   eggNOG; prNOG08870; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q8NCK3; -.
DR   OMA; FAGHQKT; -.
DR   OrthoDB; EOG9D81S4; -.
DR   PhylomeDB; Q8NCK3; -.
DR   NextBio; 91137; -.
DR   ArrayExpress; Q8NCK3; -.
DR   Bgee; Q8NCK3; -.
DR   CleanEx; HS_ZNF485; -.
DR   Genevestigator; Q8NCK3; -.
DR   GermOnline; ENSG00000198298; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 10.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 6.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    441       Zinc finger protein 485.
FT                                /FTId=PRO_0000223953.
FT   DOMAIN       11     82       KRAB.
FT   ZN_FING     130    152       C2H2-type 1.
FT   ZN_FING     158    180       C2H2-type 2.
FT   ZN_FING     186    208       C2H2-type 3.
FT   ZN_FING     214    236       C2H2-type 4.
FT   ZN_FING     242    264       C2H2-type 5.
FT   ZN_FING     270    292       C2H2-type 6.
FT   ZN_FING     298    320       C2H2-type 7.
FT   ZN_FING     326    348       C2H2-type 8.
FT   ZN_FING     354    376       C2H2-type 9.
FT   ZN_FING     382    404       C2H2-type 10.
FT   ZN_FING     410    432       C2H2-type 11.
FT   VARIANT     252    252       A -> T (in dbSNP:rs12354886).
FT                                /FTId=VAR_059920.
SQ   SEQUENCE   441 AA;  50280 MW;  34AAEC75A350EFE6 CRC64;
     MAPRAQIQGP LTFGDVAVAF TRIEWRHLDA AQRALYRDVM LENYGNLVSV GLLSSKPKLI
     TQLEQGAEPW TEVREAPSGT HAVEDYWFET KMSALKQSTS EASVLGERTK SVMMEKGLDW
     EGRSSTEKNY KCKECGKVFK YNSSFISHQR NHTSEKPHKC KECGIAFMNS SSLLNHHKVH
     AGKQPYRCIE CGKFLKKHST FINHQRIHSR EKPHKCIECG KTFRKNSILL SHQRIHTGQK
     PYKCNDCGKA FAQNAALTRH ERIHSGEKPF KCNKCGRAFR DNSTVLEHQK IHTGEKPYQC
     NECGKAFRKS STLISHQRMH TGEKPYHCSK CGKSFRYSSS FAGHQKTHSG NKPYQCRDCG
     KAFTKSSTLT GHQRIHTGEK PYHCKKCGKA FRHSSGLVEH QRLHTGEKPY KCNECGKAFP
     RSSALKQHKK IHNKERAMKC S
//