ID   ZN442_HUMAN             Reviewed;         627 AA.
AC   Q9H7R0;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   05-OCT-2010, entry version 74.
DE   RecName: Full=Zinc finger protein 442;
GN   Name=ZNF442;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   VARIANTS [LARGE SCALE ANALYSIS] SER-152 AND SER-243.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA   Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA   Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA   Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA   Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal
RT   cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 16 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
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DR   EMBL; AK024418; BAB14916.1; -; mRNA.
DR   IPI; IPI00006636; -.
DR   RefSeq; NP_110451.1; -.
DR   UniGene; Hs.253193; -.
DR   ProteinModelPortal; Q9H7R0; -.
DR   SMR; Q9H7R0; 24-84, 208-373, 290-457, 430-510, 482-584.
DR   PRIDE; Q9H7R0; -.
DR   Ensembl; ENST00000242804; ENSP00000242804; ENSG00000198342.
DR   Ensembl; ENST00000420150; ENSP00000410913; ENSG00000198342.
DR   GeneID; 79973; -.
DR   KEGG; hsa:79973; -.
DR   UCSC; uc002mtr.1; human.
DR   CTD; 79973; -.
DR   GeneCards; GC19M012460; -.
DR   HGNC; HGNC:20877; ZNF442.
DR   PharmGKB; PA134983440; -.
DR   eggNOG; prNOG10683; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q9H7R0; -.
DR   OMA; MWETIRN; -.
DR   OrthoDB; EOG9G4KB2; -.
DR   PhylomeDB; Q9H7R0; -.
DR   NextBio; 69998; -.
DR   ArrayExpress; Q9H7R0; -.
DR   Bgee; Q9H7R0; -.
DR   CleanEx; HS_ZNF442; -.
DR   Genevestigator; Q9H7R0; -.
DR   GermOnline; ENSG00000198342; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 13.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 16.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    627       Zinc finger protein 442.
FT                                /FTId=PRO_0000047591.
FT   DOMAIN       29    115       KRAB.
FT   ZN_FING     181    203       C2H2-type 1; degenerate.
FT   ZN_FING     209    231       C2H2-type 2.
FT   ZN_FING     237    259       C2H2-type 3.
FT   ZN_FING     265    287       C2H2-type 4.
FT   ZN_FING     293    315       C2H2-type 5.
FT   ZN_FING     321    343       C2H2-type 6.
FT   ZN_FING     349    371       C2H2-type 7.
FT   ZN_FING     377    399       C2H2-type 8.
FT   ZN_FING     405    427       C2H2-type 9.
FT   ZN_FING     433    455       C2H2-type 10.
FT   ZN_FING     461    482       C2H2-type 11; atypical.
FT   ZN_FING     488    510       C2H2-type 12.
FT   ZN_FING     516    538       C2H2-type 13.
FT   ZN_FING     544    566       C2H2-type 14.
FT   ZN_FING     572    594       C2H2-type 15.
FT   ZN_FING     600    622       C2H2-type 16.
FT   VARIANT      93     93       I -> V (in dbSNP:rs10423273).
FT                                /FTId=VAR_052830.
FT   VARIANT     110    110       P -> T (in dbSNP:rs10415207).
FT                                /FTId=VAR_024217.
FT   VARIANT     152    152       P -> S (in a colorectal cancer sample;
FT                                somatic mutation; dbSNP:rs10414971).
FT                                /FTId=VAR_035581.
FT   VARIANT     243    243       C -> S (in a colorectal cancer sample;
FT                                somatic mutation).
FT                                /FTId=VAR_035582.
FT   VARIANT     422    422       G -> R (in dbSNP:rs11085808).
FT                                /FTId=VAR_052831.
FT   VARIANT     443    443       R -> C (in dbSNP:rs10500210).
FT                                /FTId=VAR_024218.
SQ   SEQUENCE   627 AA;  72863 MW;  E95D75A75F807C68 CRC64;
     MIVFGGEDRS DLFLPDSQTN EERKQYDSVA FEDVAVNFTQ EEWALLGPSQ KSLYRDVMWE
     TIRNLDCIGM KWEDTNIEDQ HRNPRRSLRC HIIERFSESR QPDSTVNEKP PGVDPCKSSV
     CGEIMGCSFL NCYITFDAGH KPDECQEYGE KPHTHKQCGT AFNYHHSFQT QERPHTGKKR
     YDCKECGKTF SSSGNLRRHI IVQRGGGPYI CKLCGKAFFW PSLFRMHERT HTGEKPYECK
     QCCKAFPIYS SYLRHERTHT GEKPYECKHC SKAFPDYSSY VRHERTHTGE KPYKCKRCGR
     AFSVSSSLRI HERTHTGEKP YECKQCGKAF HHLGSFQRHM IRHTGDGPHK CKICGKGFDC
     PSSLQSHERT HTGEKPYECK QCGKALSHHS SFRSHMIMHT GDGPHKCKVC GKAFIYPSVF
     QGHERTHTGE KPYECKECGK AFRISSSLRR HETTHTGEKP YKCKCGKAFI DFYSFQNHET
     THTGEKPYEC KECGKAFSCF TYLSQHRRTH MAEKPYECKT CKKAFSHFGN LKVHERIHTG
     EKPYECKECR KAFSWLTCLL RHERIHTGKK SYECQQCGKA FTRSRFLRGH EKTHTGEKMH
     ECKECGKALS SLSSLHRHKR THWRDTL
//