ID   ZN439_HUMAN             Reviewed;         499 AA.
AC   Q8NDP4; Q8IYZ7; Q96SU1;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   05-OCT-2010, entry version 70.
DE   RecName: Full=Zinc finger protein 439;
GN   Name=ZNF439;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Substantia nigra;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-499.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-499, AND VARIANT
RP   SER-427.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 11 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB55187.1; Type=Erroneous initiation;
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DR   EMBL; AL833935; CAD38790.1; -; mRNA.
DR   EMBL; AK027542; BAB55187.1; ALT_INIT; mRNA.
DR   EMBL; BC032857; AAH32857.1; -; mRNA.
DR   IPI; IPI00168560; -.
DR   RefSeq; NP_689475.1; -.
DR   UniGene; Hs.528731; -.
DR   ProteinModelPortal; Q8NDP4; -.
DR   SMR; Q8NDP4; 19-68, 325-401, 348-465, 394-491.
DR   IntAct; Q8NDP4; 2.
DR   MINT; MINT-1475050; -.
DR   PRIDE; Q8NDP4; -.
DR   Ensembl; ENST00000304030; ENSP00000305077; ENSG00000171291.
DR   GeneID; 90594; -.
DR   KEGG; hsa:90594; -.
DR   UCSC; uc002msr.1; human.
DR   CTD; 90594; -.
DR   GeneCards; GC19P011960; -.
DR   HGNC; HGNC:20873; ZNF439.
DR   PharmGKB; PA134886330; -.
DR   eggNOG; KOG1721; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q8NDP4; -.
DR   OMA; KECGKNI; -.
DR   PhylomeDB; Q8NDP4; -.
DR   NextBio; 76862; -.
DR   ArrayExpress; Q8NDP4; -.
DR   Bgee; Q8NDP4; -.
DR   CleanEx; HS_ZNF439; -.
DR   Genevestigator; Q8NDP4; -.
DR   GermOnline; ENSG00000171291; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 9.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    499       Zinc finger protein 439.
FT                                /FTId=PRO_0000047588.
FT   DOMAIN       19    101       KRAB.
FT   ZN_FING     186    208       C2H2-type 1.
FT   ZN_FING     214    236       C2H2-type 2.
FT   ZN_FING     242    264       C2H2-type 3.
FT   ZN_FING     270    292       C2H2-type 4.
FT   ZN_FING     298    320       C2H2-type 5.
FT   ZN_FING     326    348       C2H2-type 6.
FT   ZN_FING     354    376       C2H2-type 7.
FT   ZN_FING     382    404       C2H2-type 8.
FT   ZN_FING     410    432       C2H2-type 9.
FT   ZN_FING     438    460       C2H2-type 10.
FT   ZN_FING     466    490       C2H2-type 11.
FT   VARIANT       6      6       P -> S (in dbSNP:rs10421552).
FT                                /FTId=VAR_052827.
FT   VARIANT     427    427       L -> S (in dbSNP:rs10500209).
FT                                /FTId=VAR_024216.
SQ   SEQUENCE   499 AA;  58395 MW;  483E3238E280F229 CRC64;
     MLSLSPILLY TCEMFQDPVA FKDVAVNFTQ EEWALLDISQ KNLYREVMLE TFWNLTSIGK
     KWKDQNIEYE YQNPRRNFRS VTEEKVNEIK EDSHCGETFT PVPDDRLNFQ KKKASPEVKS
     CDSFVCEVGL GNSSSNMNIR GDTGHKACEC QEYGPKPWKS QQPKKAFRYH PSLRTQERDH
     TGKKPYACKE CGKNIIYHSS IQRHMVVHSG DGPYKCKFCG KAFHCLSLYL IHERTHTGEK
     PYECKQCGKS FSYSATHRIH ERTHIGEKPY ECQECGKAFH SPRSCHRHER SHMGEKAYQC
     KECGKAFMCP RYVRRHERTH SRKKLYECKQ CGKALSSLTS FQTHIRMHSG ERPYECKTCG
     KGFYSAKSFQ RHEKTHSGEK PYKCKQCGKA FTRSGSFRYH ERTHTGEKPY ECKQCGKAFR
     SAPNLQLHGR THTGEKPYQC KECGKAFRSA SQLRIHRRIH TGEKPYECKK CGKAFRYVQN
     FRFHERTQTH KNALWRKTL
//