ID   ZN432_HUMAN             Reviewed;         652 AA.
AC   O94892;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   05-OCT-2010, entry version 85.
DE   RecName: Full=Zinc finger protein 432;
GN   Name=ZNF432; Synonyms=KIAA0798;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=99087487; PubMed=9872452; DOI=10.1093/dnares/5.5.277;
RA   Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A.,
RA   Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XI.
RT   The complete sequences of 100 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 5:277-286(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NITRATION [LARGE SCALE ANALYSIS] AT TYR-41, AND MASS SPECTROMETRY.
RC   TISSUE=Pituitary adenoma;
RX   PubMed=16777052; DOI=10.1016/j.ab.2006.05.024;
RA   Zhan X., Desiderio D.M.;
RT   "Nitroproteins from a human pituitary adenoma tissue discovered with a
RT   nitrotyrosine affinity column and tandem mass spectrometry.";
RL   Anal. Biochem. 354:279-289(2006).
RN   [4]
RP   VARIANTS [LARGE SCALE ANALYSIS] VAL-416 AND TYR-490.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA   Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA   Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA   Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA   Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal
RT   cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 16 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA34518.2; Type=Erroneous initiation;
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DR   EMBL; AB018341; BAA34518.2; ALT_INIT; mRNA.
DR   EMBL; BC002858; AAH02858.1; -; mRNA.
DR   IPI; IPI00472152; -.
DR   RefSeq; NP_055465.1; -.
DR   UniGene; Hs.655934; -.
DR   ProteinModelPortal; O94892; -.
DR   STRING; O94892; -.
DR   PRIDE; O94892; -.
DR   Ensembl; ENST00000221315; ENSP00000221315; ENSG00000197619.
DR   GeneID; 9668; -.
DR   KEGG; hsa:9668; -.
DR   UCSC; uc002pyk.1; human.
DR   CTD; 9668; -.
DR   GeneCards; GC19M052467; -.
DR   HGNC; HGNC:20810; ZNF432.
DR   PharmGKB; PA134935907; -.
DR   eggNOG; prNOG08034; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; O94892; -.
DR   OMA; KVFTMKS; -.
DR   PhylomeDB; O94892; -.
DR   NextBio; 36303; -.
DR   ArrayExpress; O94892; -.
DR   Bgee; O94892; -.
DR   Genevestigator; O94892; -.
DR   GermOnline; ENSG00000196442; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 15.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 7.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 16.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE   1: Evidence at protein level;
KW   Complete proteome; DNA-binding; Metal-binding; Nitration; Nucleus;
KW   Polymorphism; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    652       Zinc finger protein 432.
FT                                /FTId=PRO_0000047580.
FT   DOMAIN        8     79       KRAB.
FT   ZN_FING     205    227       C2H2-type 1.
FT   ZN_FING     233    255       C2H2-type 2.
FT   ZN_FING     261    283       C2H2-type 3.
FT   ZN_FING     289    311       C2H2-type 4.
FT   ZN_FING     317    339       C2H2-type 5.
FT   ZN_FING     345    367       C2H2-type 6.
FT   ZN_FING     373    395       C2H2-type 7.
FT   ZN_FING     401    423       C2H2-type 8.
FT   ZN_FING     429    451       C2H2-type 9.
FT   ZN_FING     457    479       C2H2-type 10.
FT   ZN_FING     485    507       C2H2-type 11.
FT   ZN_FING     513    535       C2H2-type 12.
FT   ZN_FING     541    563       C2H2-type 13.
FT   ZN_FING     567    591       C2H2-type 14.
FT   ZN_FING     597    619       C2H2-type 15.
FT   ZN_FING     625    647       C2H2-type 16.
FT   MOD_RES      41     41       Nitrated tyrosine.
FT   VARIANT     416    416       L -> V (in a breast cancer sample;
FT                                somatic mutation).
FT                                /FTId=VAR_035577.
FT   VARIANT     490    490       C -> Y (in a breast cancer sample;
FT                                somatic mutation).
FT                                /FTId=VAR_035578.
SQ   SEQUENCE   652 AA;  74836 MW;  14B61461EE54A6EB CRC64;
     MINAQELLTL EDVTVEFTWE EWQLLGPFQK DLYRDVMLEI YSNLLSMGYQ VSKPDALSKL
     ERGEEPWTME DERHSRICPE NNEVDDHLQD HLENQRMLKS VEQYHEHNAF GNTASQTKSL
     CLFRENHDTF ELYIKTLKSN LSLVNQNKSC EINNSTKFSG DGKSFLHGNY EELYSAAKFS
     VSTKANSTKS QVSKHQRTHE IEKNHVCSEC GKAFVKKSQL TDHERVHTGE KPYGCTLCAK
     VFSRKSRLNE HQRIHKREKS FICSECGKVF TMKSRLIEHQ RTHTGEKPYI CNECGKGFPG
     KRNLIVHQRN HTGEKSYICS ECGKGFTGKS MLIIHQRTHT GEKPYICSEC GKGFTTKHYV
     IIHQRNHTGE KPYICNECGK GFTMKSRMIE HQRTHTGEKP YICSECGKGF PRKSNLIVHQ
     RNHTVEKSYL CSECGKGFTV KSMLIIHQRT HTGEKPYTCS ECGKGFPLKS RLIVHQRTHT
     GEKPYRCSEC GKGFIVNSGL MLHQRTHTGE KPYICNECGK GFAFKSNLVV HQRTHTGEKP
     FMCSECGKGF TMKRYLIVHQ QIHTEEKSCI CSECGRGFAK ETELALHKQV HTGEKPYGCN
     ECGKGFTMKS RLIVHQRTHT GEKPFVCSEC RKAFSSKRNL IVHQRTHNGN KP
//