ID   ZN418_HUMAN             Reviewed;         676 AA.
AC   Q8TF45; Q2M1S2; Q670L5; Q96N18;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2002, sequence version 2.
DT   05-OCT-2010, entry version 73.
DE   RecName: Full=Zinc finger protein 418;
GN   Name=ZNF418; Synonyms=KIAA1956;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RA   Li Y., Wang Q., Yuan W., Zhu C., Wu X., Liu M.;
RT   "ZNF418, a novel KRAB-containing zinc finger protein, is a
RT   transcription repressor.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=21842142; PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA   Nagase T., Kikuno R., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XXII.
RT   The complete sequences of 50 new cDNA clones which code for large
RT   proteins.";
RL   DNA Res. 8:319-327(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcriptional repressor.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 16 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB85542.1; Type=Erroneous initiation;
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DR   EMBL; AY695825; AAU05132.1; -; mRNA.
DR   EMBL; AB075836; BAB85542.1; ALT_INIT; mRNA.
DR   EMBL; AK056113; BAB71096.1; -; mRNA.
DR   EMBL; BC112244; AAI12245.1; -; mRNA.
DR   EMBL; BC113707; AAI13708.1; -; mRNA.
DR   IPI; IPI00152845; -.
DR   RefSeq; NP_597717.1; -.
DR   UniGene; Hs.660728; -.
DR   ProteinModelPortal; Q8TF45; -.
DR   PeptideAtlas; Q8TF45; -.
DR   PRIDE; Q8TF45; -.
DR   Ensembl; ENST00000396147; ENSP00000379451; ENSG00000196724.
DR   Ensembl; ENST00000425570; ENSP00000407039; ENSG00000196724.
DR   GeneID; 147686; -.
DR   KEGG; hsa:147686; -.
DR   UCSC; uc002qqs.1; human.
DR   CTD; 147686; -.
DR   GeneCards; GC19M058296; -.
DR   HGNC; HGNC:20647; ZNF418.
DR   PharmGKB; PA134912102; -.
DR   eggNOG; prNOG06348; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q8TF45; -.
DR   OMA; SFSHKGS; -.
DR   OrthoDB; EOG9R52NH; -.
DR   PhylomeDB; Q8TF45; -.
DR   NextBio; 85679; -.
DR   ArrayExpress; Q8TF45; -.
DR   Bgee; Q8TF45; -.
DR   CleanEx; HS_ZNF418; -.
DR   Genevestigator; Q8TF45; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 16.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 10.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 17.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE   1: Evidence at protein level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    676       Zinc finger protein 418.
FT                                /FTId=PRO_0000047573.
FT   DOMAIN        5     91       KRAB.
FT   ZN_FING      82    105       C2H2-type 1.
FT   ZN_FING     230    252       C2H2-type 2.
FT   ZN_FING     258    280       C2H2-type 3.
FT   ZN_FING     286    308       C2H2-type 4.
FT   ZN_FING     314    336       C2H2-type 5.
FT   ZN_FING     342    364       C2H2-type 6.
FT   ZN_FING     370    392       C2H2-type 7.
FT   ZN_FING     398    420       C2H2-type 8.
FT   ZN_FING     426    448       C2H2-type 9.
FT   ZN_FING     454    476       C2H2-type 10.
FT   ZN_FING     482    504       C2H2-type 11.
FT   ZN_FING     510    532       C2H2-type 12.
FT   ZN_FING     538    560       C2H2-type 13.
FT   ZN_FING     591    613       C2H2-type 14.
FT   ZN_FING     619    641       C2H2-type 15.
FT   ZN_FING     647    669       C2H2-type 16.
FT   CONFLICT    290    290       E -> G (in Ref. 3; BAB71096).
SQ   SEQUENCE   676 AA;  77858 MW;  1BB0F0064B8F3BD3 CRC64;
     MQGTVAFEDV AVNFSQEEWS LLSEVQRCLY HDVMLENWVL ISSLGCWCGS EDEEAPSKKS
     ISIQRVSQVS TPGAGVSPKK AHSCEMCGAI LGDILHLADH QGTHHKQKLH RCEAWGNKLY
     DSSNRPHQNQ YLGEKPYRSS VEEALFVKRC KFHVSEESSI FIQSGKDFLP SSGLLLQEAT
     HTGEKSNSKP ECESPFQWGD THYSCGECMK HSSTKHVFVQ QQRLPSREEC YCWECGKSFS
     KYDSVSNHQR VHTGKRPYEC GECGKSFSHK GSLVQHQRVH TGKRPYECGE CGKSFSHKGS
     LVQHQRVHTG ERPYECGECG KSFSQNGTLI KHQRVHTGER PYECEECGKC FTQKGNLIQH
     QRGHTSERPY ECEECGKCFS QKGTLTEHHR VHTRERPYEC GECGKSFSRK GHLRNHQRGH
     TGERPYECGE CGKSFSRKGN LIQHQRSHTG ERPYECRECR KLFRGKSHLI EHQRVHTGER
     PYECNECGKS FQDSSGFRVH QRVHTGEKPF ECSECGKSFP QSCSLLRHRR VHTGERPYEC
     GECGKSFHQS SSLLRHQKTH TAERPYECRE CGKFFSSLLE HRRVHTGERP YECRECGKTF
     TRRSAHFKHQ RLHTRGKPYE CSECGKSFAE TFSLTEHRRV HTGERPYECS ECGKSFHRSS
     SLLRHQRVHT ERSPYK
//