ID   ZN416_HUMAN             Reviewed;         594 AA.
AC   Q9BWM5; Q9NWW8;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   05-OCT-2010, entry version 70.
DE   RecName: Full=Zinc finger protein 416;
GN   Name=ZNF416;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cervix;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-483.
RC   TISSUE=Carcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA91257.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
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DR   EMBL; BC000130; AAH00130.1; -; mRNA.
DR   EMBL; AK000564; BAA91257.1; ALT_SEQ; mRNA.
DR   IPI; IPI00020818; -.
DR   RefSeq; NP_060349.1; -.
DR   UniGene; Hs.247711; -.
DR   ProteinModelPortal; Q9BWM5; -.
DR   SMR; Q9BWM5; 25-70, 268-405, 351-518.
DR   PRIDE; Q9BWM5; -.
DR   Ensembl; ENST00000196489; ENSP00000196489; ENSG00000083817.
DR   GeneID; 55659; -.
DR   KEGG; hsa:55659; -.
DR   UCSC; uc002qpf.1; human.
DR   CTD; 55659; -.
DR   GeneCards; GC19M058082; -.
DR   HGNC; HGNC:20645; ZNF416.
DR   PharmGKB; PA134905500; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q9BWM5; -.
DR   OMA; YTLVEHQ; -.
DR   OrthoDB; EOG9F4VWD; -.
DR   PhylomeDB; Q9BWM5; -.
DR   NextBio; 60387; -.
DR   ArrayExpress; Q9BWM5; -.
DR   Bgee; Q9BWM5; -.
DR   CleanEx; HS_ZNF416; -.
DR   Genevestigator; Q9BWM5; -.
DR   GermOnline; ENSG00000083817; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 11.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 9.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    594       Zinc finger protein 416.
FT                                /FTId=PRO_0000233984.
FT   DOMAIN       28    111       KRAB.
FT   ZN_FING     242    264       C2H2-type 1; degenerate.
FT   ZN_FING     270    292       C2H2-type 2.
FT   ZN_FING     298    320       C2H2-type 3.
FT   ZN_FING     326    348       C2H2-type 4.
FT   ZN_FING     354    376       C2H2-type 5.
FT   ZN_FING     382    404       C2H2-type 6.
FT   ZN_FING     410    432       C2H2-type 7.
FT   ZN_FING     438    460       C2H2-type 8.
FT   ZN_FING     466    488       C2H2-type 9.
FT   ZN_FING     494    516       C2H2-type 10.
FT   ZN_FING     522    544       C2H2-type 11.
FT   ZN_FING     550    572       C2H2-type 12.
FT   CONFLICT    463    463       E -> I (in Ref. 2).
SQ   SEQUENCE   594 AA;  67188 MW;  6ABC5ED049066C6D CRC64;
     MAAAVLRDST SVPVTAEAKL MGFTQGCVTF EDVAIYFSQE EWGLLDEAQR LLYRDVMLEN
     FALITALVCW HGMEDEETPE QSVSVEGVPQ VRTPEASPST QKIQSCDMCV PFLTDILHLT
     DLPGQELYLT GACAVFHQDQ KHHSAEKPLE SDMDKASFVQ CCLFHESGMP FTSSEVGKDF
     LAPLGILQPQ AIANYEKPNK ISKCEEAFHV GISHYKWSQC RRESSHKHTF FHPRVCTGKR
     LYESSKCGKA CCCECSLVQL QRVHPGERPY ECSECGKSFS QTSHLNDHRR IHTGERPYVC
     GQCGKSFSQR ATLIKHHRVH TGERPYECGE CGKSFSQSSN LIEHCRIHTG ERPYECDECG
     KAFGSKSTLV RHQRTHTGEK PYECGECGKL FRQSFSLVVH QRIHTTARPY ECGQCGKSFS
     LKCGLIQHQL IHSGARPFEC DECGKSFSQR TTLNKHHKVH TAERPYVCGE CGKAFMFKSK
     LVRHQRTHTG ERPFECSECG KFFRQSYTLV EHQKIHTGLR PYDCGQCGKS FIQKSSLIQH
     QVVHTGERPY ECGKCGKSFT QHSGLILHRK SHTVERPRDS SKCGKPYSPR SNIV
//