ID   ZN383_HUMAN             Reviewed;         475 AA.
AC   Q8NA42; Q6X2C7;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   05-OCT-2010, entry version 66.
DE   RecName: Full=Zinc finger protein 383;
GN   Name=ZNF383; ORFNames=HSD17;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryonic heart;
RX   PubMed=15964543; DOI=10.1016/j.bbrc.2005.05.193;
RA   Cao L., Wang Z., Zhu C., Zhao Y., Yuan W., Li J., Wang Y., Ying Z.,
RA   Li Y., Yu W., Wu X., Liu M.;
RT   "ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK
RT   signaling pathway.";
RL   Biochem. Biophys. Res. Commun. 333:1050-1059(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RA   Hu T.H., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.;
RT   "A new spermatogenesis-related gene.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: May function as a transcriptional repressor, suppressing
CC       transcriptional activities mediated by MAPK signaling pathways.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttling between
CC       the nucleus and cytoplasm may occur under different stimulation
CC       and growth conditions.
CC   -!- TISSUE SPECIFICITY: Expressed in heart, placenta, liver, pancreas
CC       and with a higher level in skeletal muscle.
CC   -!- DEVELOPMENTAL STAGE: In tissues from a six months embryo, highly
CC       expressed in heart, testis and skeletal muscle, lower expression
CC       levels in kidney, intestines and prostate.
CC   -!- DOMAIN: The KRAB domain is responsible for the transcriptional
CC       repressor activity.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 11 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
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DR   EMBL; AY438646; AAR14184.1; -; mRNA.
DR   EMBL; AY260141; AAP20067.1; -; mRNA.
DR   EMBL; AK093182; BAC04086.1; -; mRNA.
DR   IPI; IPI00167901; -.
DR   RefSeq; NP_689817.1; -.
DR   UniGene; Hs.590975; -.
DR   ProteinModelPortal; Q8NA42; -.
DR   SMR; Q8NA42; 2-54, 195-249, 223-390, 279-446, 308-451.
DR   PRIDE; Q8NA42; -.
DR   Ensembl; ENST00000352998; ENSP00000340132; ENSG00000188283.
DR   Ensembl; ENST00000392155; ENSP00000375996; ENSG00000188283.
DR   GeneID; 163087; -.
DR   KEGG; hsa:163087; -.
DR   UCSC; uc002ofs.1; human.
DR   CTD; 163087; -.
DR   GeneCards; GC19P037709; -.
DR   HGNC; HGNC:18609; ZNF383.
DR   PharmGKB; PA134903145; -.
DR   eggNOG; prNOG04230; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q8NA42; -.
DR   OMA; FSQNSQF; -.
DR   OrthoDB; EOG9CG2TW; -.
DR   PhylomeDB; Q8NA42; -.
DR   NextBio; 88300; -.
DR   ArrayExpress; Q8NA42; -.
DR   Bgee; Q8NA42; -.
DR   CleanEx; HS_ZNF383; -.
DR   Genevestigator; Q8NA42; -.
DR   GermOnline; ENSG00000188283; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 11.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 9.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    475       Zinc finger protein 383.
FT                                /FTId=PRO_0000047550.
FT   DOMAIN        6     77       KRAB.
FT   ZN_FING     170    192       C2H2-type 1.
FT   ZN_FING     198    220       C2H2-type 2.
FT   ZN_FING     226    248       C2H2-type 3.
FT   ZN_FING     254    276       C2H2-type 4.
FT   ZN_FING     282    304       C2H2-type 5.
FT   ZN_FING     310    332       C2H2-type 6.
FT   ZN_FING     338    360       C2H2-type 7.
FT   ZN_FING     366    388       C2H2-type 8.
FT   ZN_FING     394    416       C2H2-type 9.
FT   ZN_FING     422    444       C2H2-type 10.
FT   ZN_FING     450    472       C2H2-type 11.
FT   CONFLICT     11     11       V -> A (in Ref. 2; AAP20067).
FT   CONFLICT    114    114       Y -> H (in Ref. 2; AAP20067).
FT   CONFLICT    443    443       I -> V (in Ref. 2; AAP20067).
SQ   SEQUENCE   475 AA;  54613 MW;  2F47070F5C2E582B CRC64;
     MAEGSVMFSD VSIDFSQEEW DCLDPVQRDL YRDVMLENYG NLVSMGLYTP KPQVISLLEQ
     GKEPWMVGRE LTRGLCSDLE SMCETKLLSL KKEVYEIELC QREIMGLTKH GLEYSSFGDV
     LEYRSHLAKQ LGYPNGHFSQ EIFTPEYMPT FIQQTFLTLH QIINNEDRPY ECKKCGKAFS
     QNSQFIQHQR IHIGEKSYEC KECGKFFSCG SHVTRHLKIH TGEKPFECKE CGKAFSCSSY
     LSQHQRIHTG KKPYECKECG KAFSYCSNLI DHQRIHTGEK PYECKVCGKA FTKSSQLFQH
     ARIHTGEKPY ECKECGKAFT QSSKLVQHQR IHTGEKPYEC KECGKAFSSG SALTNHQRIH
     TGEKPYDCKE CGKAFTQSSQ LRQHQRIHAG EKPFECLECG KAFTQNSQLF QHQRIHTDEK
     PYECNECGKA FNKCSNLTRH LRIHTGEKPY NCKECGKAFS SGSDLIRHQG IHTNK
//