ID   ZN337_HUMAN             Reviewed;         751 AA.
AC   Q9Y3M9; Q9Y3Y5;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 2.
DT   05-OCT-2010, entry version 95.
DE   RecName: Full=Zinc finger protein 337;
GN   Name=ZNF337;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 256-751.
RC   TISSUE=Brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 20 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
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DR   EMBL; AL031673; CAB43548.2; -; Genomic_DNA.
DR   EMBL; BC021298; AAH21298.1; -; mRNA.
DR   EMBL; AL049942; CAB43216.1; -; mRNA.
DR   IPI; IPI00000110; -.
DR   PIR; T08674; T08674.
DR   RefSeq; NP_056470.1; -.
DR   UniGene; Hs.633621; -.
DR   UniGene; Hs.661684; -.
DR   ProteinModelPortal; Q9Y3M9; -.
DR   IntAct; Q9Y3M9; 3.
DR   MINT; MINT-1422645; -.
DR   PhosphoSite; Q9Y3M9; -.
DR   PRIDE; Q9Y3M9; -.
DR   Ensembl; ENST00000252979; ENSP00000252979; ENSG00000130684.
DR   Ensembl; ENST00000376436; ENSP00000365619; ENSG00000130684.
DR   GeneID; 26152; -.
DR   KEGG; hsa:26152; -.
DR   UCSC; uc002wva.1; human.
DR   CTD; 26152; -.
DR   GeneCards; GC20M025654; -.
DR   HGNC; HGNC:15809; ZNF337.
DR   PharmGKB; PA38043; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q9Y3M9; -.
DR   OMA; GFIQKST; -.
DR   OrthoDB; EOG9PG8MP; -.
DR   PhylomeDB; Q9Y3M9; -.
DR   NextBio; 48229; -.
DR   ArrayExpress; Q9Y3M9; -.
DR   Bgee; Q9Y3M9; -.
DR   CleanEx; HS_ZNF337; -.
DR   Genevestigator; Q9Y3M9; -.
DR   GermOnline; ENSG00000130684; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 16.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 6.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 20.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 19.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 20.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    751       Zinc finger protein 337.
FT                                /FTId=PRO_0000047540.
FT   DOMAIN       12     83       KRAB.
FT   ZN_FING     180    202       C2H2-type 1; degenerate.
FT   ZN_FING     208    230       C2H2-type 2.
FT   ZN_FING     236    258       C2H2-type 3.
FT   ZN_FING     264    286       C2H2-type 4.
FT   ZN_FING     292    314       C2H2-type 5.
FT   ZN_FING     320    342       C2H2-type 6.
FT   ZN_FING     348    370       C2H2-type 7.
FT   ZN_FING     376    398       C2H2-type 8.
FT   ZN_FING     404    426       C2H2-type 9.
FT   ZN_FING     432    454       C2H2-type 10.
FT   ZN_FING     460    482       C2H2-type 11.
FT   ZN_FING     488    510       C2H2-type 12.
FT   ZN_FING     516    538       C2H2-type 13.
FT   ZN_FING     544    566       C2H2-type 14.
FT   ZN_FING     572    594       C2H2-type 15.
FT   ZN_FING     600    622       C2H2-type 16.
FT   ZN_FING     628    650       C2H2-type 17.
FT   ZN_FING     656    679       C2H2-type 18.
FT   ZN_FING     685    707       C2H2-type 19.
FT   ZN_FING     713    735       C2H2-type 20.
FT   VARIANT      17     17       V -> I (in dbSNP:rs926487).
FT                                /FTId=VAR_024213.
FT   VARIANT     467    467       R -> G (in dbSNP:rs16987972).
FT                                /FTId=VAR_052814.
FT   CONFLICT    476    476       T -> A (in Ref. 3; CAB43216).
FT   CONFLICT    653    653       E -> V (in Ref. 3; CAB43216).
SQ   SEQUENCE   751 AA;  86875 MW;  482D9F9A57EC980E CRC64;
     MGPQGARRQA FLAFGDVTVD FTQKEWRLLS PAQRALYREV TLENYSHLVS LGILHSKPEL
     IRRLEQGEVP WGEERRRRPG PCAGIYAEHV LRPKNLGLAH QRQQQLQFSD QSFQSDTAEG
     QEKEKSTKPM AFSSPPLRHA VSSRRRNSVV EIESSQGQRE NPTEIDKVLK GIENSRWGAF
     KCAERGQDFS RKMMVIIHKK AHSRQKLFTC RECHQGFRDE SALLLHQNTH TGEKSYVCSV
     CGRGFSLKAN LLRHQRTHSG EKPFLCKVCG RGYTSKSYLT VHERTHTGEK PYECQECGRR
     FNDKSSYNKH LKAHSGEKPF VCKECGRGYT NKSYFVVHKR IHSGEKPYRC QECGRGFSNK
     SHLITHQRTH SGEKPFACRQ CKQSFSVKGS LLRHQRTHSG EKPFVCKDCE RSFSQKSTLV
     YHQRTHSGEK PFVCRECGQG FIQKSTLVKH QITHSEEKPF VCKDCGRGFI QKSTFTLHQR
     THSEEKPYGC RECGRRFRDK SSYNKHLRAH LGEKRFFCRD CGRGFTLKPN LTIHQRTHSG
     EKPFMCKQCE KSFSLKANLL RHQWTHSGER PFNCKDCGRG FILKSTLLFH QKTHSGEKPF
     ICSECGQGFI WKSNLVKHQL AHSGKQPFVC KECGRGFNWK GNLLTHQRTH SGEKPFVCNV
     CGQGFSWKRS LTRHHWRIHS KEKPFVCQEC KRGYTSKSDL TVHERIHTGE RPYECQECGR
     KFSNKSYYSK HLKRHLREKR FCTGSVGEAS S
//