ID   ZN283_HUMAN             Reviewed;         679 AA.
AC   Q8N7M2; B4DGZ5; B7WP04; Q6RFR9; Q86WM6;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 4.
DT   05-OCT-2010, entry version 71.
DE   RecName: Full=Zinc finger protein 283;
DE   AltName: Full=Zinc finger protein HZF19;
GN   Name=ZNF283;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-314.
RC   TISSUE=Brain, and Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 85-242, AND TISSUE SPECIFICITY.
RC   TISSUE=Brain;
RX   MEDLINE=22683274; PubMed=12743021; DOI=10.1101/gr.963903;
RA   Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT   "Differential expansion of zinc-finger transcription factor loci in
RT   homologous human and mouse gene clusters.";
RL   Genome Res. 13:1097-1110(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 172-679, AND VARIANT ILE-314.
RX   MEDLINE=95169271; PubMed=7865130; DOI=10.1089/dna.1995.14.125;
RA   Abrink M., Aveskogh M., Hellman L.;
RT   "Isolation of cDNA clones for 42 different Kruppel-related zinc finger
RT   proteins expressed in the human monoblast cell line U-937.";
RL   DNA Cell Biol. 14:125-136(1995).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- TISSUE SPECIFICITY: Detected in prostate, testis, and pancreas.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 15 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC05251.1; Type=Miscellaneous discrepancy; Note=Compared to the genome, the sequence lacks 6 bp for unexplained reasons;
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DR   EMBL; AK098175; BAC05251.1; ALT_SEQ; mRNA.
DR   EMBL; AK294852; BAG57956.1; -; mRNA.
DR   EMBL; AC011508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY166784; AAO45833.1; -; mRNA.
DR   EMBL; AY500359; AAS55109.1; -; mRNA.
DR   IPI; IPI00791390; -.
DR   RefSeq; NP_862828.1; -.
DR   UniGene; Hs.652513; -.
DR   ProteinModelPortal; Q8N7M2; -.
DR   Ensembl; ENST00000324461; ENSP00000327314; ENSG00000159882.
DR   GeneID; 284349; -.
DR   KEGG; hsa:284349; -.
DR   CTD; 284349; -.
DR   GeneCards; GC19P044272; -.
DR   HGNC; HGNC:13077; ZNF283.
DR   PharmGKB; PA37653; -.
DR   eggNOG; prNOG17549; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q8N7M2; -.
DR   ArrayExpress; Q8N7M2; -.
DR   Bgee; Q8N7M2; -.
DR   CleanEx; HS_ZNF283; -.
DR   Genevestigator; Q8N7M2; -.
DR   GermOnline; ENSG00000176232; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 15.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 6.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 15.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    679       Zinc finger protein 283.
FT                                /FTId=PRO_0000047507.
FT   DOMAIN       73    152       KRAB.
FT   ZN_FING     205    227       C2H2-type 1.
FT   ZN_FING     233    255       C2H2-type 2.
FT   ZN_FING     261    283       C2H2-type 3.
FT   ZN_FING     289    311       C2H2-type 4.
FT   ZN_FING     317    339       C2H2-type 5.
FT   ZN_FING     345    367       C2H2-type 6.
FT   ZN_FING     373    395       C2H2-type 7.
FT   ZN_FING     401    423       C2H2-type 8.
FT   ZN_FING     429    451       C2H2-type 9.
FT   ZN_FING     457    479       C2H2-type 10.
FT   ZN_FING     485    507       C2H2-type 11.
FT   ZN_FING     513    535       C2H2-type 12.
FT   ZN_FING     541    563       C2H2-type 13.
FT   ZN_FING     569    591       C2H2-type 14.
FT   ZN_FING     597    619       C2H2-type 15.
FT   VARIANT     314    314       T -> I (in dbSNP:rs2195980).
FT                                /FTId=VAR_060605.
FT   VARIANT     629    629       R -> H (in dbSNP:rs1061768).
FT                                /FTId=VAR_057416.
FT   VARIANT     638    638       C -> R (in dbSNP:rs2356437).
FT                                /FTId=VAR_060606.
FT   VARIANT     638    638       C -> Y (in dbSNP:rs1061769).
FT                                /FTId=VAR_060607.
FT   VARIANT     646    646       R -> I (in dbSNP:rs10417624).
FT                                /FTId=VAR_057417.
FT   CONFLICT    139    140       Missing (in Ref. 1; BAG57956).
FT   CONFLICT    172    172       E -> R (in Ref. 4; AAS55109).
FT   CONFLICT    432    432       E -> K (in Ref. 4; AAS55109).
FT   CONFLICT    638    638       C -> H (in Ref. 1; BAC05251/BAG57956 and
FT                                4; AAS55109).
SQ   SEQUENCE   679 AA;  77942 MW;  ADB64BFD18D49020 CRC64;
     MESRSVAQAG VQWCDLGSLQ APPPGFTLFS CLSLLSSWDY SSGFSGFCAS PIEESHGALI
     SSCNSRTMTD GLVTFRDVAI DFSQEEWECL DPAQRDLYVD VMLENYSNLV SLDLESKTYE
     TKKIFSENDI FEINFSQWEM KDKSKTLGLE ASIFRNNWKC KSIFEGLKGH QEGYFSQMII
     SYEKIPSYRK SKSLTPHQRI HNTEKSYVCK ECGKACSHGS KLVQHERTHT AEKHFECKEC
     GKNYLSAYQL NVHQRFHTGE KPYECKECGK TFSWGSSLVK HERIHTGEKP YECKECGKAF
     SRGYHLTQHQ KIHTGVKSYK CKECGKAFFW GSSLAKHEII HTGEKPYKCK ECGKAFSRGY
     QLTQHQKIHT GKKPYECKIC GKAFCWGYQL TRHQIFHTGE KPYECKECGK AFNCGSSLIQ
     HERIHTGEKP YECKECGKAF SRGYHLSQHQ KIHTGEKPFE CKECGKAFSW GSSLVKHERV
     HTGEKSHECK ECGKTFCSGY QLTRHQVFHT GEKPYECKEC GKAFNCGSSL VQHERIHTGE
     KPYECKECGK AFSRGYHLTQ HQKIHTGEKP FKCKECGKAF SWGSSLVKHE RVHTNEKSYE
     CKDCGKAFGS GYQLSVHQRF HTGEKLYQRK EFGKTFTCGS KLVHERTHSN DKPYKYNECG
     EAFLWTTYSN EKIDTDETL
//