ID ZN252_HUMAN Reviewed; 682 AA. AC Q8WUN3; DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot. DT 02-SEP-2008, sequence version 2. DT 05-OCT-2010, entry version 60. DE RecName: Full=Zinc finger protein 252; GN Name=ZNF252; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., RA Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., RA Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., RA Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T., RA Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., RA DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., RA Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., RA Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., RA O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., RA Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., RA Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., RA Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., RA Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., RA Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-413, AND VARIANTS ARG-167 RP AND PRO-189. RC TISSUE=Cervix; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May be involved in transcriptional regulation (By CC similarity). CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. CC -!- SIMILARITY: Contains 18 C2H2-type zinc fingers. CC -!- CAUTION: Product of a dubious gene prediction. CC -!- SEQUENCE CAUTION: CC Sequence=BC019922; Type=Erroneous initiation; Note=Translation N-terminally shortened; CC Sequence=BC019922; Type=Erroneous termination; Positions=414; Note=Translated as Tyr; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF235103; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC019922; -; NOT_ANNOTATED_CDS; mRNA. DR IPI; IPI00785055; -. DR HSSP; P17028; 1X6E. DR ProteinModelPortal; Q8WUN3; -. DR Ensembl; ENST00000355436; ENSP00000347611; ENSG00000196922. DR UCSC; uc003zew.2; human. DR GeneCards; GC08M146173; -. DR GeneCards; GC08M146174; -. DR HGNC; HGNC:13046; ZNF252. DR PharmGKB; PA37624; -. DR eggNOG; prNOG16619; -. DR HOGENOM; HBG717200; -. DR HOVERGEN; HBG018163; -. DR InParanoid; Q8WUN3; -. DR OMA; CEKSFSA; -. DR OrthoDB; EOG9ZCWPM; -. DR ArrayExpress; Q8WUN3; -. DR Bgee; Q8WUN3; -. DR CleanEx; HS_ZNF252; -. DR Genevestigator; Q8WUN3; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0045449; P:regulation of transcription; IEA:UniProtKB-KW. DR GO; GO:0006350; P:transcription; IEA:UniProtKB-KW. DR InterPro; IPR007087; Znf_C2H2. DR InterPro; IPR015880; Znf_C2H2-like. DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd. DR Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 17. DR Pfam; PF00096; zf-C2H2; 8. DR SMART; SM00355; ZnF_C2H2; 18. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18. PE 5: Uncertain; KW Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1 682 Zinc finger protein 252. FT /FTId=PRO_0000348065. FT ZN_FING 162 184 C2H2-type 1; degenerate. FT ZN_FING 190 212 C2H2-type 2; atypical. FT ZN_FING 218 240 C2H2-type 3. FT ZN_FING 246 268 C2H2-type 4. FT ZN_FING 274 296 C2H2-type 5. FT ZN_FING 302 324 C2H2-type 6. FT ZN_FING 330 352 C2H2-type 7. FT ZN_FING 358 380 C2H2-type 8. FT ZN_FING 386 408 C2H2-type 9. FT ZN_FING 414 436 C2H2-type 10. FT ZN_FING 449 471 C2H2-type 11. FT ZN_FING 477 499 C2H2-type 12. FT ZN_FING 505 527 C2H2-type 13. FT ZN_FING 533 555 C2H2-type 14. FT ZN_FING 561 583 C2H2-type 15. FT ZN_FING 589 611 C2H2-type 16. FT ZN_FING 617 639 C2H2-type 17. FT ZN_FING 645 667 C2H2-type 18. FT VARIANT 167 167 C -> R (in dbSNP:rs2979109). FT /FTId=VAR_046093. FT VARIANT 189 189 T -> P (in dbSNP:rs12678688). FT /FTId=VAR_046094. SQ SEQUENCE 682 AA; 78705 MW; E6D6CBC3133D8152 CRC64; MIPKQDISEE LESQRAKSED HVRNIFKETE EMSKTEGKLE NCWRKYAVEG VKNSFSQKSN FREITMRYVK TLSRENGQKF NAVGENCITD SNPAKHLRGS REESLHPSVS SVENLQQHED LINLQSFQLG ERAYQTDVLV KVPRQSSVLS ENQRMNNPER WFESTGCGKT YNQNRAFNQH QRFHSGEKTY EHNECGKAFS WPSILSKHQR IHTGKKLYTC EDCGKSFSVH SYFIQHCKIH TREKPYECIK CGKAFSTHSS YVQHLKIHTG EKHHECNQCG KAFSHSSNLI HHQRIHSGEK PYKCKECGKA FNRQSNLIQH QRIHSGEKPY DCKECGKAFS TQLFLIQHQR IHTGEKPYEC NECAKSFSLN RTLTVHQRIH TGEKPYRCNE CGKSFSQCSQ VIQHKRIHTG EKPYICNECG KSFGARLSLI QHQRIHTGEK PYGCREKPYE CSECGKAFSQ SFNLIHHQRT HNGEKSYECN ECDKAFSLLS SLVQHQRIHN GDKPYECHKC GKAFSQGSHL IQHQRSHIGE KPYECNECGK TFGQISTLIK HERTHNGEKP YECSDCGKAF SQSAHLIHHQ RIHTGENPYE CSECGKAFNV CSSLIQHHRI HTGEKPYECS DCGKAFSQHS QFIQHQRIHT GEKPYMCNEC EKSFSACLSL IQHKRIHTGE KPYVCAKCGK SF //