ID   ZN225_HUMAN             Reviewed;         706 AA.
AC   Q9UK10; A8K8S2; Q53F12; Q9NS46; Q9UID8;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 2.
DT   05-OCT-2010, entry version 91.
DE   RecName: Full=Zinc finger protein 225;
GN   Name=ZNF225;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=22683274; PubMed=12743021; DOI=10.1101/gr.963903;
RA   Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT   "Differential expansion of zinc-finger transcription factor loci in
RT   homologous human and mouse gene clusters.";
RL   Genome Res. 13:1097-1110(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Synovial cell;
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-283, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 18 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
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DR   EMBL; AF187991; AAF04107.1; -; mRNA.
DR   EMBL; AK223477; BAD97197.1; -; mRNA.
DR   EMBL; AK292437; BAF85126.1; -; mRNA.
DR   EMBL; AC021092; AAF24967.1; -; Genomic_DNA.
DR   EMBL; AC074331; AAF88105.1; -; Genomic_DNA.
DR   EMBL; CH471126; EAW57255.1; -; Genomic_DNA.
DR   EMBL; BC108912; AAI08913.1; -; mRNA.
DR   IPI; IPI00007035; -.
DR   RefSeq; NP_037494.2; -.
DR   UniGene; Hs.279567; -.
DR   ProteinModelPortal; Q9UK10; -.
DR   PhosphoSite; Q9UK10; -.
DR   PRIDE; Q9UK10; -.
DR   Ensembl; ENST00000262894; ENSP00000262894; ENSG00000159882.
DR   GeneID; 7768; -.
DR   KEGG; hsa:7768; -.
DR   UCSC; uc002oyj.1; human.
DR   CTD; 7768; -.
DR   GeneCards; GC19P044269; -.
DR   HGNC; HGNC:13018; ZNF225.
DR   PharmGKB; PA37597; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q9UK10; -.
DR   PhylomeDB; Q9UK10; -.
DR   NextBio; 30071; -.
DR   ArrayExpress; Q9UK10; -.
DR   Bgee; Q9UK10; -.
DR   CleanEx; HS_ZNF225; -.
DR   Genevestigator; Q9UK10; -.
DR   GermOnline; ENSG00000159904; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 16.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 8.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 17.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE   1: Evidence at protein level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Phosphoprotein; Polymorphism; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    706       Zinc finger protein 225.
FT                                /FTId=PRO_0000047466.
FT   DOMAIN        8     78       KRAB.
FT   ZN_FING     176    198       C2H2-type 1.
FT   ZN_FING     204    226       C2H2-type 2.
FT   ZN_FING     232    254       C2H2-type 3.
FT   ZN_FING     260    282       C2H2-type 4.
FT   ZN_FING     288    310       C2H2-type 5.
FT   ZN_FING     316    338       C2H2-type 6.
FT   ZN_FING     344    366       C2H2-type 7.
FT   ZN_FING     372    394       C2H2-type 8.
FT   ZN_FING     400    422       C2H2-type 9.
FT   ZN_FING     428    450       C2H2-type 10.
FT   ZN_FING     456    478       C2H2-type 11.
FT   ZN_FING     484    506       C2H2-type 12.
FT   ZN_FING     512    534       C2H2-type 13.
FT   ZN_FING     540    562       C2H2-type 14.
FT   ZN_FING     568    590       C2H2-type 15.
FT   ZN_FING     596    618       C2H2-type 16.
FT   ZN_FING     624    646       C2H2-type 17.
FT   ZN_FING     652    674       C2H2-type 18; degenerate.
FT   MOD_RES     283    283       Phosphothreonine.
FT   VARIANT      50     50       Q -> R (in dbSNP:rs34863330).
FT                                /FTId=VAR_033560.
FT   VARIANT     679    679       T -> S (in dbSNP:rs16978738).
FT                                /FTId=VAR_033561.
FT   CONFLICT    144    147       RQKP -> KTET (in Ref. 1; AAF04107).
FT   CONFLICT    219    219       L -> Q (in Ref. 1; AAF04107).
SQ   SEQUENCE   706 AA;  82471 MW;  4C357A3AB1E32FB2 CRC64;
     MTTLKEAVTF KDVAVVFTEE ELRLLDLAQR KLYREVMLEN FRNLLSVGHQ SLHRDTFHFL
     KEEKFWMMET ATQREGNLGG KIQMEMETVS ESGTHEGLFS HQTWEQISSD LTRFQDSMVN
     SFQFSKQDDM PCQVDAGLSI IHVRQKPSEG RTCKKSFSDV SVLDLHQQLQ SREKSHTCDE
     CGKSFCYSSA LRIHQRVHMG EKLYNCDVCG KEFNQSSHLQ IHQRIHTGEK PFKCEQCGKG
     FSRRSGLYVH RKLHTGVKPH ICEKCGKAFI HDSQLQEHQR IHTGEKPFKC DICCKSFRSR
     ANLNRHSMVH MREKPFRCDT CGKSFGLKSA LNSHRMVHTG EKRYKCEECG KRFIYRQDLY
     KHQIDHTGEK PYNCKECGKS FRWASGLSRH VRVHSGETTF KCEECGKGFY TNSQRYSHQR
     AHSGEKPYRC EECGKGYKRR LDLDFHQRVH RGEKPYNCKE CGKSFGWASC LLNHQRIHSG
     EKPFKCEECG KRFTQNSQLY THRRVHSGEK PFKCEECGKR FTQNSQLYSH RRVHTGVKPY
     KCEECGKGFN SKFNLDMHQR VHTGERPYNC KECGKSFSRA SSILNHKRLH GDEKPFKCEE
     CGKRFTENSQ LHSHQRVHTG EKPYKCEKCG KSFRWASTHL THQRLHSREK LLQCEDCGKS
     IVHSSCLKDQ QRDQSGEKTS KCEDCGKRYK RRLNLDTLLS LFLNDT
//