ID   ZN175_HUMAN             Reviewed;         711 AA.
AC   Q9Y473; A8K9H2;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   05-OCT-2010, entry version 96.
DE   RecName: Full=Zinc finger protein 175;
DE   AltName: Full=Zinc finger protein OTK18;
GN   Name=ZNF175;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fetal brain;
RX   MEDLINE=96435435; PubMed=8838321; DOI=10.1006/geno.1996.0062;
RA   Saito H., Fujiwara T., Takahashi E., Shin S., Okui K., Nakamura Y.;
RT   "Isolation and mapping of a novel human gene encoding a protein
RT   containing zinc-finger structures.";
RL   Genomics 31:376-379(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   CHARACTERIZATION, AND ANTIRETROVIRAL ACTIVITY.
RX   PubMed=14688346;
RA   Carlson K.A., Leisman G., Limoges J., Pohlman G.D., Horiba M.,
RA   Buescher J., Gendelman H.E., Ikezu T.;
RT   "Molecular characterization of a putative antiretroviral
RT   transcriptional factor, OTK18.";
RL   J. Immunol. 172:381-391(2004).
CC   -!- FUNCTION: Down-regulates the expression of several chemokine
CC       receptors. Interferes with HIV-1 replication by suppressing Tat-
CC       induced viral LTR promoter activity.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- INDUCTION: By HIV-1 infection.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 15 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; D50419; BAA23362.1; -; mRNA.
DR   EMBL; AK292687; BAF85376.1; -; mRNA.
DR   EMBL; AC018755; AAF87843.1; -; Genomic_DNA.
DR   EMBL; CH471135; EAW72030.1; -; Genomic_DNA.
DR   EMBL; BC052997; AAH52997.1; -; mRNA.
DR   IPI; IPI00000388; -.
DR   RefSeq; NP_009078.1; -.
DR   UniGene; Hs.119014; -.
DR   ProteinModelPortal; Q9Y473; -.
DR   STRING; Q9Y473; -.
DR   PhosphoSite; Q9Y473; -.
DR   REPRODUCTION-2DPAGE; Q9Y473; -.
DR   PRIDE; Q9Y473; -.
DR   Ensembl; ENST00000262259; ENSP00000262259; ENSG00000105497.
DR   GeneID; 7728; -.
DR   KEGG; hsa:7728; -.
DR   UCSC; uc002pxb.1; human.
DR   CTD; 7728; -.
DR   GeneCards; GC19P052074; -.
DR   HGNC; HGNC:12964; ZNF175.
DR   HPA; HPA002717; -.
DR   MIM; 601139; gene.
DR   PharmGKB; PA37546; -.
DR   eggNOG; prNOG16250; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q9Y473; -.
DR   OMA; FNGRSNF; -.
DR   OrthoDB; EOG9KSS4Z; -.
DR   PhylomeDB; Q9Y473; -.
DR   NextBio; 29930; -.
DR   ArrayExpress; Q9Y473; -.
DR   Bgee; Q9Y473; -.
DR   CleanEx; HS_ZNF175; -.
DR   Genevestigator; Q9Y473; -.
DR   GermOnline; ENSG00000105497; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:transcription factor activity; TAS:ProtInc.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0009615; P:response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 12.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 10.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 14.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE   1: Evidence at protein level;
KW   Antiviral defense; Complete proteome; Cytoplasm; DNA-binding;
KW   Metal-binding; Nucleus; Polymorphism; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    711       Zinc finger protein 175.
FT                                /FTId=PRO_0000047440.
FT   DOMAIN       27     98       KRAB.
FT   ZN_FING     279    301       C2H2-type 1; atypical.
FT   ZN_FING     307    329       C2H2-type 2; atypical.
FT   ZN_FING     335    357       C2H2-type 3.
FT   ZN_FING     363    385       C2H2-type 4.
FT   ZN_FING     391    413       C2H2-type 5.
FT   ZN_FING     419    441       C2H2-type 6.
FT   ZN_FING     447    469       C2H2-type 7.
FT   ZN_FING     475    497       C2H2-type 8.
FT   ZN_FING     503    525       C2H2-type 9.
FT   ZN_FING     531    553       C2H2-type 10.
FT   ZN_FING     559    581       C2H2-type 11.
FT   ZN_FING     587    609       C2H2-type 12.
FT   ZN_FING     615    637       C2H2-type 13.
FT   ZN_FING     643    665       C2H2-type 14.
FT   ZN_FING     671    693       C2H2-type 15.
FT   MOTIF       359    362       Nuclear localization signal (Potential).
FT   VARIANT     363    363       Y -> N (in dbSNP:rs60097262).
FT                                /FTId=VAR_061938.
FT   VARIANT     505    505       C -> R (in dbSNP:rs3764548).
FT                                /FTId=VAR_052789.
SQ   SEQUENCE   711 AA;  81609 MW;  43FB8ACD1B3094A2 CRC64;
     MPADVNLSQK PQVLGPEKQD GSCEASVSFE DVTVDFSREE WQQLDPAQRC LYRDVMLELY
     SHLFAVGYHI PNPEVIFRML KEKEPRVEEA EVSHQRCQER EFGLEIPQKE ISKKASFQKD
     MVGEFTRDGS WCSILEELRL DADRTKKDEQ NQIQPMSHSA FFNKKTLNTE SNCEYKDPGK
     MIRTRPHLAS SQKQPQKCCL FTESLKLNLE VNGQNESNDT EQLDDVVGSG QLFSHSSSDA
     CSKNIHTGET FCKGNQCRKV CGHKQSLKQH QIHTQKKPDG CSECGGSFTQ KSHLFAQQRI
     HSVGNLHECG KCGKAFMPQL KLSVYLTDHT GDIPCICKEC GKVFIQRSEL LTHQKTHTRK
     KPYKCHDCGK AFFQMLSLFR HQRTHSREKL YECSECGKGF SQNSTLIIHQ KIHTGERQYA
     CSECGKAFTQ KSTLSLHQRI HSGQKSYVCI ECGQAFIQKA HLIVHQRSHT GEKPYQCHNC
     GKSFISKSQL DIHHRIHTGE KPYECSDCGK TFTQKSHLNI HQKIHTGERH HVCSECGKAF
     NQKSILSMHQ RIHTGEKPYK CSECGKAFTS KSQFKEHQRI HTGEKPYVCT ECGKAFNGRS
     NFHKHQITHT RERPFVCYKC GKAFVQKSEL ITHQRTHMGE KPYECLDCGK SFSKKPQLKV
     HQRIHTGERP YVCSECGKAF NNRSNFNKHQ TTHTRDKSYK CSYSVKGFTK Q
//