ID   ZN135_HUMAN             Reviewed;         658 AA.
AC   P52742; Q5U5L3;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   05-OCT-2010, entry version 84.
DE   RecName: Full=Zinc finger protein 135;
DE   AltName: Full=Zinc finger protein 61;
DE   AltName: Full=Zinc finger protein 78-like 1;
GN   Name=ZNF135; Synonyms=ZNF61, ZNF78L1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-22.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 166-658.
RC   TISSUE=Insulinoma;
RX   MEDLINE=96044430; PubMed=7557990; DOI=10.1006/geno.1995.1040;
RA   Tommerup N., Vissing H.;
RT   "Isolation and fine mapping of 16 novel human zinc finger-encoding
RT   cDNAs identify putative candidate genes for developmental and
RT   malignant disorders.";
RL   Genomics 27:259-264(1995).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 16 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC50254.1; Type=Frameshift; Positions=207, 558, 563;
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DR   EMBL; BC046434; AAH46434.1; -; mRNA.
DR   EMBL; U09413; AAC50254.1; ALT_FRAME; mRNA.
DR   IPI; IPI00395473; -.
DR   PIR; I38600; I38600.
DR   UniGene; Hs.85863; -.
DR   ProteinModelPortal; P52742; -.
DR   STRING; P52742; -.
DR   Ensembl; ENST00000313434; ENSP00000321406; ENSG00000176293.
DR   UCSC; uc002qre.1; human.
DR   GeneCards; GC19P058571; -.
DR   HGNC; HGNC:12919; ZNF135.
DR   HPA; HPA006961; -.
DR   MIM; 604077; gene.
DR   PharmGKB; PA37507; -.
DR   eggNOG; prNOG16961; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; P52742; -.
DR   PhylomeDB; P52742; -.
DR   NextBio; 29824; -.
DR   ArrayExpress; P52742; -.
DR   Bgee; P52742; -.
DR   CleanEx; HS_ZNF135; -.
DR   Genevestigator; P52742; -.
DR   GermOnline; ENSG00000176293; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003700; F:transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 16.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 13.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 16.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    658       Zinc finger protein 135.
FT                                /FTId=PRO_0000047419.
FT   DOMAIN       14     85       KRAB.
FT   ZN_FING     214    236       C2H2-type 1.
FT   ZN_FING     242    264       C2H2-type 2.
FT   ZN_FING     270    292       C2H2-type 3.
FT   ZN_FING     298    320       C2H2-type 4.
FT   ZN_FING     326    348       C2H2-type 5.
FT   ZN_FING     354    376       C2H2-type 6.
FT   ZN_FING     382    404       C2H2-type 7.
FT   ZN_FING     410    432       C2H2-type 8.
FT   ZN_FING     438    460       C2H2-type 9.
FT   ZN_FING     466    488       C2H2-type 10.
FT   ZN_FING     494    516       C2H2-type 11.
FT   ZN_FING     522    544       C2H2-type 12.
FT   ZN_FING     550    572       C2H2-type 13.
FT   ZN_FING     578    600       C2H2-type 14.
FT   ZN_FING     606    628       C2H2-type 15.
FT   ZN_FING     634    656       C2H2-type 16.
FT   VARIANT      22     22       G -> D (in dbSNP:rs1469087).
FT                                /FTId=VAR_052774.
FT   VARIANT     507    507       S -> L (in dbSNP:rs2228277).
FT                                /FTId=VAR_052775.
FT   VARIANT     517    517       T -> A (in dbSNP:rs2228278).
FT                                /FTId=VAR_052776.
FT   VARIANT     579    579       G -> R (in dbSNP:rs2228279).
FT                                /FTId=VAR_052777.
FT   VARIANT     592    592       S -> L (in dbSNP:rs2228275).
FT                                /FTId=VAR_052778.
FT   CONFLICT    166    166       G -> R (in Ref. 2; AAC50254).
SQ   SEQUENCE   658 AA;  75261 MW;  ED6A4FB042CB3CE5 CRC64;
     MTPGVRVSTD PEQVTFEDVV VGFSQEEWGQ LKPAQRTLYR DVMLDTFRLL VSVGHWLPKP
     NVISLLEQEA ELWAVESRLP QGVYPDLETR PKVKLSVLKQ GISEEISNSV ILVERFLWDG
     LWYCRGEDTE GHWEWSCESL ESLAVPVAFT PVKTPVLEQW QRNGFGENIS LNPDLPHQPM
     TPERQSPHTW GTRGKREKPD LNVLQKTCVK EKPYKCQECG KAFSHSSALI EHHRTHTGER
     PYECHECLKG FRNSSALTKH QRIHTGEKPY KCTQCGRTFN QIAPLIQHQR THTGEKPYEC
     SECGKSFSFR SSFSQHERTH TGEKPYECSE CGKAFRQSIH LTQHLRIHTG EKPYQCGECG
     KAFSHSSSLT KHQRIHTGEK PYECHECGKA FTQITPLIQH QRTHTGEKPY ECGECGKAFS
     QSTLLTEHRR IHTGEKPYGC NECGKTFSHS SSLSQHERTH TGEKPYECSQ CGKAFRQSTH
     LTQHQRIHTG EKPYECNDCG KAFSHSSSLT KHQRIHTGEK PYECNQCGRA FSQLAPLIQH
     QRIHTGEKPY ECNQCGRAFS QSSLLIEHQR IHTKEKPYGC NECGKSFSHS SSLSQHERTH
     TGEKPYECHD CGKSFRQSTH LTQHRRIHTG EKPYACRDCG KAFTHSSSLT KHQRTHTG
//