ID   ZN789_HUMAN             Reviewed;         425 AA.
AC   Q5FWF6; A4D282; Q6ZMZ9;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 3.
DT   05-OCT-2010, entry version 57.
DE   RecName: Full=Zinc finger protein 789;
GN   Name=ZNF789;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Spleen;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22616434; PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA   Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA   Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA   Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA   Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA   Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA   Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA   Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA   Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA   Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA   Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA   Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA   Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA   Mural R.J., Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP   ALA-77.
RC   TISSUE=Lymph;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5FWF6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5FWF6-2; Sequence=VSP_026561;
CC         Note=No experimental confirmation available. Ref.1 (BAD18576)
CC         sequence differs from that shown due to frameshifts in positions
CC         85 and 271;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 8 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL23876.1; Type=Erroneous gene model prediction;
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DR   EMBL; AK131429; BAD18576.1; ALT_FRAME; mRNA.
DR   EMBL; CH236956; EAL23875.1; -; Genomic_DNA.
DR   EMBL; CH236956; EAL23876.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC089424; AAH89424.2; -; mRNA.
DR   IPI; IPI00412697; -.
DR   IPI; IPI00746127; -.
DR   RefSeq; NP_998768.2; -.
DR   UniGene; Hs.440384; -.
DR   HSSP; P17028; 1X6E.
DR   ProteinModelPortal; Q5FWF6; -.
DR   SMR; Q5FWF6; 5-59, 198-311, 225-340, 255-393, 282-421.
DR   PRIDE; Q5FWF6; -.
DR   Ensembl; ENST00000331410; ENSP00000331927; ENSG00000198556.
DR   GeneID; 285989; -.
DR   UCSC; uc003uqq.1; human.
DR   UCSC; uc003uqr.1; human.
DR   CTD; 285989; -.
DR   GeneCards; GC07P099072; -.
DR   HGNC; HGNC:27801; ZNF789.
DR   HPA; HPA029500; -.
DR   eggNOG; prNOG17995; -.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q5FWF6; -.
DR   OMA; AKSYECS; -.
DR   NextBio; 95914; -.
DR   ArrayExpress; Q5FWF6; -.
DR   Bgee; Q5FWF6; -.
DR   CleanEx; HS_ZNF789; -.
DR   Genevestigator; Q5FWF6; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 8.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 8.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Polymorphism; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    425       Zinc finger protein 789.
FT                                /FTId=PRO_0000293697.
FT   DOMAIN       11     82       KRAB.
FT   ZN_FING     201    223       C2H2-type 1.
FT   ZN_FING     229    251       C2H2-type 2.
FT   ZN_FING     257    279       C2H2-type 3.
FT   ZN_FING     285    307       C2H2-type 4.
FT   ZN_FING     313    335       C2H2-type 5.
FT   ZN_FING     341    363       C2H2-type 6.
FT   ZN_FING     369    391       C2H2-type 7.
FT   ZN_FING     397    419       C2H2-type 8.
FT   VAR_SEQ       1     95       Missing (in isoform 2).
FT                                /FTId=VSP_026561.
FT   VARIANT      77     77       T -> A (in dbSNP:rs6962772).
FT                                /FTId=VAR_052903.
FT   CONFLICT    398    398       Q -> R (in Ref. 1; BAD18576).
SQ   SEQUENCE   425 AA;  49984 MW;  00BF9778A9340CFA CRC64;
     MFPPARGKEL LSFEDVAMYF TREEWGHLNW GQKDLYRDVM LENYRNMVLL GFQFPKPEMI
     CQLENWDEQW ILDLPRTGNR KASGSACPGS EARHKMKKLT PKQKFSEDLE SYKISVVMQE
     SAEKLSEKLH KCKEFVDSCR LTFPTSGDEY SRGFLQNLNL IQDQNAQTRW KQGRYDEDGK
     PFNQRSLLLG HERILTRAKS YECSECGKVI RRKAWFDQHQ RIHFLENPFE CKVCGQAFRQ
     RSALTVHKQC HLQNKPYRCH DCGKCFRQLA YLVEHKRIHT KEKPYKCSKC EKTFSQNSTL
     IRHQVIHSGE KRHKCLECGK AFGRHSTLLC HQQIHSKPNT HKCSECGQSF GRNVDLIQHQ
     RIHTKEEFFQ CGECGKTFSF KRNLFRHQVI HTGSQPYQCV ICGKSFKWHT SFIKHQGTHK
     GQIST
//