ID ZN445_HUMAN Reviewed; 1031 AA. AC P59923; Q3MJD1; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 10-OCT-2003, sequence version 1. DT 05-OCT-2010, entry version 63. DE RecName: Full=Zinc finger protein 445; DE AltName: Full=Zinc finger protein 168; DE AltName: Full=Zinc finger protein with KRAB and SCAN domains 15; GN Name=ZNF445; Synonyms=ZKSCAN15, ZNF168; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Shan Y.X., Luo K.T., Guo Z.K., Tang W.W., Ye G.M., Yu L., Huang C.Q.; RT "Cloning and characterization of a novel zinc finger protein."; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May be involved in transcriptional regulation. CC -!- SUBCELLULAR LOCATION: Nucleus (Potential). CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. CC -!- SIMILARITY: Contains 14 C2H2-type zinc fingers. CC -!- SIMILARITY: Contains 1 KRAB domain. CC -!- SIMILARITY: Contains 1 SCAN box domain. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY262260; AAP36990.1; -; mRNA. DR EMBL; AY295873; AAP50258.1; -; mRNA. DR EMBL; BC101486; AAI01487.1; -; mRNA. DR IPI; IPI00377116; -. DR RefSeq; NP_852466.1; -. DR UniGene; Hs.250481; -. DR ProteinModelPortal; P59923; -. DR IntAct; P59923; 1. DR STRING; P59923; -. DR PRIDE; P59923; -. DR Ensembl; ENST00000296111; ENSP00000296111; ENSG00000185219. DR Ensembl; ENST00000396077; ENSP00000379387; ENSG00000185219. DR Ensembl; ENST00000425708; ENSP00000413073; ENSG00000185219. DR GeneID; 353274; -. DR KEGG; hsa:353274; -. DR UCSC; uc003cnf.2; human. DR CTD; 353274; -. DR GeneCards; GC03M044481; -. DR HGNC; HGNC:21018; ZNF445. DR HPA; HPA006678; -. DR PharmGKB; PA134904986; -. DR eggNOG; prNOG05702; -. DR HOGENOM; HBG717200; -. DR HOVERGEN; HBG106583; -. DR InParanoid; P59923; -. DR OMA; FWCQECG; -. DR OrthoDB; EOG944P5K; -. DR PhylomeDB; P59923; -. DR NextBio; 99754; -. DR ArrayExpress; P59923; -. DR Bgee; P59923; -. DR CleanEx; HS_ZNF445; -. DR Genevestigator; P59923; -. DR GermOnline; ENSG00000185219; Homo sapiens. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003700; F:transcription factor activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. DR GO; GO:0006350; P:transcription; IEA:UniProtKB-KW. DR InterPro; IPR001909; Krueppel-associated_box. DR InterPro; IPR003309; Tscrpt_reg_SCAN. DR InterPro; IPR007087; Znf_C2H2. DR InterPro; IPR015880; Znf_C2H2-like. DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd. DR Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 11. DR Pfam; PF01352; KRAB; 1. DR Pfam; PF02023; SCAN; 1. DR Pfam; PF00096; zf-C2H2; 7. DR SMART; SM00349; KRAB; 1. DR SMART; SM00431; SCAN; 1. DR SMART; SM00355; ZnF_C2H2; 14. DR SUPFAM; SSF109640; Krueppel-associated_box; 1. DR PROSITE; PS50805; KRAB; 1. DR PROSITE; PS50804; SCAN_BOX; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14. PE 2: Evidence at transcript level; KW Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1 1031 Zinc finger protein 445. FT /FTId=PRO_0000047594. FT DOMAIN 55 137 SCAN box. FT DOMAIN 234 304 KRAB. FT ZN_FING 485 507 C2H2-type 1. FT ZN_FING 513 535 C2H2-type 2. FT ZN_FING 541 563 C2H2-type 3. FT ZN_FING 597 619 C2H2-type 4. FT ZN_FING 625 647 C2H2-type 5. FT ZN_FING 681 703 C2H2-type 6. FT ZN_FING 709 731 C2H2-type 7. FT ZN_FING 762 784 C2H2-type 8. FT ZN_FING 790 812 C2H2-type 9. FT ZN_FING 840 862 C2H2-type 10. FT ZN_FING 868 890 C2H2-type 11. FT ZN_FING 896 918 C2H2-type 12. FT ZN_FING 978 1000 C2H2-type 13. FT ZN_FING 1006 1028 C2H2-type 14. FT VARIANT 428 428 Y -> C (in dbSNP:rs11710965). FT /FTId=VAR_052832. SQ SEQUENCE 1031 AA; 118963 MW; 39C288802894006E CRC64; MPPGRWHAAY PAQAQSSRER GRLQTVKKEE EDESYTPVQA ARPQTLNRPG QELFRQLFRQ LRYHESSGPL ETLSRLRELC RWWLRPDVLS KAQILELLVL EQFLSILPGE LRVWVQLHNP ESGEEAVALL EELQRDLDGT SWRDPGPAQS PDVHWMGTGA LRSAQIWSLA SPLRSSSALG DHLEPPYEIE ARDFLAGQSD TPAAQMPALF PREGCPGDQV TPTRSLTAQL QETMTFKDVE VTFSQDEWGW LDSAQRNLYR DVMLENYRNM ASLVGPFTKP ALISWLEARE PWGLNMQAAQ PKGNPVAAPT GDDLQSKTNK FILNQEPLEE AETLAVSSGC PATSVSEGIG LRESFQQKSR QKDQCENPIQ VRVKKEETNF SHRTGKDSEV SGSNSLDLKH VTYLRVSGRK ESLKHGCGKH FRMSSHHYDY KKYGKGLRHM IGGFSLHQRI HSGLKGNKKD VCGKDFSLSS HHQRGQSLHT VGVSFKCSDC GRTFSHSSHL AYHQRLHTQE KAFKCRVCGK AFRWSSNCAR HEKIHTGVKP YKCDLCEKAF RRLSAYRLHR ETHAKKKFLE LNQYRAALTY SSGFDHHLGD QSGEKLFDCS QCRKSFHCKS YVLEHQRIHT QEKPYKCTKC RKTFRWRSNF TRHMRLHEEE KFYKQDECRE GFRQSPDCSQ PQGAPAVEKT FLCQQCGKTF TRKKTLVDHQ RIHTGEKPYQ CSDCGKDFAY RSAFIVHKKK HAMKRKPEGG PSFSQDTVFQ VPQSSHSKEE PYKCSQCGKA FRNHSFLLIH QRVHTGEKPY KCRECGKAFR WSSNLYRHQR IHSLQKQYDC HESEKTPNVE PKILTGEKRF WCQECGKTFT RKRTLLDHKG IHSGEKRYKC NLCGKSYDRN YRLVNHQRIH STERPFKCQW CGKEFIGRHT LSSHQRKHTR AAQAERSPPA RSSSQDTKLR LQKLKPSEEM PLEDCKEACS QSSRLTGLQD ISIGKKCHKC SICGKTFNKS SQLISHKRFH TRERPFKCSK CGKTFRWSSN LARHMKNHIR D //