ID   ZN384_HUMAN             Reviewed;         577 AA.
AC   Q8TF68; O15407; Q8N938;
DT   28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   05-OCT-2010, entry version 78.
DE   RecName: Full=Zinc finger protein 384;
DE   AltName: Full=CAG repeat protein 1;
DE   AltName: Full=CAS-interacting zinc finger protein;
DE   AltName: Full=Nuclear matrix transcription factor 4;
DE            Short=Nuclear matrix protein 4;
DE   AltName: Full=Trinucleotide repeat-containing gene 1 protein;
GN   Name=ZNF384; Synonyms=CAGH1, CIZ, NMP4, TNRC1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RA   Matsuo M.Y.;
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 395-577.
RC   TISSUE=Brain cortex;
RX   MEDLINE=97369492; PubMed=9225980; DOI=10.1007/s004390050476;
RA   Margolis R.L., Abraham M.R., Gatchell S.B., Li S.-H., Kidwai A.S.,
RA   Breschel T.S., Stine O.C., Callahan C., McInnis M.G., Ross C.A.;
RT   "cDNAs with long CAG trinucleotide repeats from human brain.";
RL   Hum. Genet. 100:114-122(1997).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- FUNCTION: Transcription factor that binds the consensus DNA
CC       sequence [GC]AAAAA. Seems to bind and regulate the promoters of
CC       MMP1, MMP3, MMP7 and COL1A1 (By similarity).
CC   -!- SUBUNIT: Interacts with BCAR1 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=Additional isoforms seem to exist;
CC       Name=1;
CC         IsoId=Q8TF68-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8TF68-2; Sequence=VSP_006920;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 8 C2H2-type zinc fingers.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org//Genes/ZNF384ID42881ch12p13.html";
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DR   EMBL; AB070238; BAB85125.1; -; Genomic_DNA.
DR   EMBL; AK095734; BAC04618.1; -; mRNA.
DR   EMBL; AC125494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; U80738; AAB91437.1; -; mRNA.
DR   IPI; IPI00152875; -.
DR   IPI; IPI00220697; -.
DR   RefSeq; NP_001035005.1; -.
DR   RefSeq; NP_001035007.1; -.
DR   RefSeq; NP_001129206.1; -.
DR   RefSeq; NP_597733.2; -.
DR   UniGene; Hs.103315; -.
DR   UniGene; Hs.708126; -.
DR   UniGene; Hs.714839; -.
DR   ProteinModelPortal; Q8TF68; -.
DR   SMR; Q8TF68; 226-369, 254-426.
DR   STRING; Q8TF68; -.
DR   PhosphoSite; Q8TF68; -.
DR   PRIDE; Q8TF68; -.
DR   Ensembl; ENST00000396801; ENSP00000380019; ENSG00000126746.
DR   GeneID; 171017; -.
DR   KEGG; hsa:171017; -.
DR   UCSC; uc001qpz.1; human.
DR   CTD; 171017; -.
DR   GeneCards; GC12M006775; -.
DR   HGNC; HGNC:11955; ZNF384.
DR   HPA; HPA004051; -.
DR   MIM; 609951; gene.
DR   PharmGKB; PA36644; -.
DR   eggNOG; prNOG16267; -.
DR   HOGENOM; HBG716110; -.
DR   HOVERGEN; HBG058173; -.
DR   InParanoid; Q8TF68; -.
DR   PhylomeDB; Q8TF68; -.
DR   NextBio; 89172; -.
DR   ArrayExpress; Q8TF68; -.
DR   Bgee; Q8TF68; -.
DR   CleanEx; HS_ZNF384; -.
DR   Genevestigator; Q8TF68; -.
DR   GermOnline; ENSG00000126746; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IDA:HPA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 4.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 8.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Phosphoprotein; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    577       Zinc finger protein 384.
FT                                /FTId=PRO_0000047552.
FT   ZN_FING     228    250       C2H2-type 1.
FT   ZN_FING     256    278       C2H2-type 2.
FT   ZN_FING     284    306       C2H2-type 3.
FT   ZN_FING     317    339       C2H2-type 4.
FT   ZN_FING     345    367       C2H2-type 5.
FT   ZN_FING     373    397       C2H2-type 6.
FT   ZN_FING     403    425       C2H2-type 7.
FT   ZN_FING     433    455       C2H2-type 8.
FT   COMPBIAS    461    521       Gln-rich.
FT   COMPBIAS    466    499       Ala-rich.
FT   MOD_RES     214    214       Phosphoserine.
FT   VAR_SEQ     300    360       Missing (in isoform 2).
FT                                /FTId=VSP_006920.
FT   CONFLICT    501    501       Missing (in Ref. 1; BAB85125, 2; BAC04618
FT                                and 4; AAB91437).
SQ   SEQUENCE   577 AA;  63219 MW;  5899CAB02DBBE0CB CRC64;
     MEESHFNSNP YFWPSIPTVS GQIENTMFIN KMKDQLLPEK GCGLAPPHYP TLLTVPASVS
     LPSGISMDTE SKSDQLTPHS QASVTQNITV VPVPSTGLMT AGVSCSQRWR REGSQSRGPG
     LVITSPSGSL VTTASSAQTF PISAPMIVSA LPPGSQALQV VPDLSKKVAS TLTEEGGGGG
     GGGGSVAPKP PRGRKKKRML ESGLPEMNDP YVLSPEDDDD HQKDGKTYRC RMCSLTFYSK
     SEMQIHSKSH TETKPHKCPH CSKTFANSSY LAQHIRIHSG AKPYSCNFCE KSFRQLSHLQ
     QHTRIHSKMH TETIKPHKCP HCSKTFANTS YLAQHLRIHS GAKPYNCSYC QKAFRQLSHL
     QQHTRIHTGD RPYKCAHPGC EKAFTQLSNL QSHRRQHNKD KPFKCHNCHR AYTDAASLEV
     HLSTHTVKHA KVYTCTICSR AYTSETYLMK HMRKHNPPDL QQQVQAAAAA AAVAQAQAQA
     QAQAQAQAQA QAQAQASQAS QQQQQQQQQQ QQQQQQPPPH FQSPGAAPQG GGGGDSNPNP
     PPQCSFDLTP YKTAEHHKDI CLTVTTSTIQ VEHLASS
//