ID   ZN330_HUMAN             Reviewed;         320 AA.
AC   Q9Y3S2; B2RDA3;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   05-OCT-2010, entry version 76.
DE   RecName: Full=Zinc finger protein 330;
DE   AltName: Full=Nucleolar autoantigen 36;
DE   AltName: Full=Nucleolar cysteine-rich protein;
GN   Name=ZNF330; Synonyms=NOA36;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RX   MEDLINE=20062865; PubMed=10593942; DOI=10.1074/jbc.274.51.36456;
RA   Bolivar J., Diaz I., Iglesias C., Valdivia M.M.;
RT   "Molecular cloning of a zinc finger autoantigen transiently associated
RT   with interphase nucleolus and mitotic centromeres and midbodies.
RT   Orthologous proteins with nine CXXC motifs highly conserved from
RT   nematodes to humans.";
RL   J. Biol. Chem. 274:36456-36464(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bolivar J.;
RT   "Genomic structure and chromosomal localization of the human zinc
RT   finger autoantigen NOA36.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-308 AND TYR-315, AND
RP   MASS SPECTROMETRY.
RX   PubMed=15592455; DOI=10.1038/nbt1046;
RA   Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA   Zha X.-M., Polakiewicz R.D., Comb M.J.;
RT   "Immunoaffinity profiling of tyrosine phosphorylation in cancer
RT   cells.";
RL   Nat. Biotechnol. 23:94-101(2005).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RA   Colinge J., Superti-Furga G., Bennett K.L.;
RL   Submitted (OCT-2008) to UniProtKB.
CC   -!- INTERACTION:
CC       Q9H9D4:ZNF408; NbExp=1; IntAct=EBI-373456, EBI-347633;
CC   -!- SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Chromosome,
CC       centromere. Note=Predominantly expressed in the nucleolus. In
CC       mitosis associated with centromeres and concentrated at the
CC       midbody in cytokinesis.
CC   -!- TISSUE SPECIFICITY: Widely expressed. Higher expression seen in
CC       heart and skeletal muscle.
CC   -!- SIMILARITY: Belongs to the NOA36 family.
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DR   EMBL; AJ006591; CAB43112.1; -; mRNA.
DR   EMBL; AJ404873; CAC18679.1; -; Genomic_DNA.
DR   EMBL; AJ404874; CAC18679.1; JOINED; Genomic_DNA.
DR   EMBL; AJ404875; CAC18679.1; JOINED; Genomic_DNA.
DR   EMBL; AJ404876; CAC18679.1; JOINED; Genomic_DNA.
DR   EMBL; AJ404877; CAC18679.1; JOINED; Genomic_DNA.
DR   EMBL; AJ404878; CAC18679.1; JOINED; Genomic_DNA.
DR   EMBL; AJ404879; CAC18679.1; JOINED; Genomic_DNA.
DR   EMBL; AJ404880; CAC18679.1; JOINED; Genomic_DNA.
DR   EMBL; AK315463; BAG37850.1; -; mRNA.
DR   EMBL; CH471056; EAX05089.1; -; Genomic_DNA.
DR   EMBL; BC004421; AAH04421.1; -; mRNA.
DR   IPI; IPI00004942; -.
DR   RefSeq; NP_055302.1; -.
DR   UniGene; Hs.120766; -.
DR   ProteinModelPortal; Q9Y3S2; -.
DR   IntAct; Q9Y3S2; 2.
DR   STRING; Q9Y3S2; -.
DR   PhosphoSite; Q9Y3S2; -.
DR   PeptideAtlas; Q9Y3S2; -.
DR   PRIDE; Q9Y3S2; -.
DR   Ensembl; ENST00000262990; ENSP00000262990; ENSG00000109445.
DR   GeneID; 27309; -.
DR   KEGG; hsa:27309; -.
DR   UCSC; uc003iiq.2; human.
DR   CTD; 27309; -.
DR   GeneCards; GC04P142142; -.
DR   HGNC; HGNC:15462; ZNF330.
DR   HPA; HPA015705; -.
DR   MIM; 609550; gene.
DR   PharmGKB; PA134925405; -.
DR   HOGENOM; HBG714422; -.
DR   HOVERGEN; HBG057282; -.
DR   InParanoid; Q9Y3S2; -.
DR   OMA; ACFCDEH; -.
DR   PhylomeDB; Q9Y3S2; -.
DR   NextBio; 50311; -.
DR   ArrayExpress; Q9Y3S2; -.
DR   Bgee; Q9Y3S2; -.
DR   CleanEx; HS_ZNF330; -.
DR   Genevestigator; Q9Y3S2; -.
DR   GermOnline; ENSG00000109445; Homo sapiens.
DR   GO; GO:0000775; C:chromosome, centromeric region; IDA:UniProtKB.
DR   GO; GO:0030496; C:midbody; IDA:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR010531; NOA36.
DR   PANTHER; PTHR13214; NOA36; 1.
DR   Pfam; PF06524; NOA36; 1.
PE   1: Evidence at protein level;
KW   Centromere; Chromosome; Complete proteome; Metal-binding; Nucleus;
KW   Phosphoprotein; Polymorphism; Zinc; Zinc-finger.
FT   CHAIN         1    320       Zinc finger protein 330.
FT                                /FTId=PRO_0000066590.
FT   ZN_FING      42     58       C4-type 1 (Potential).
FT   ZN_FING      67    104       C4-type 2 (Potential).
FT   ZN_FING     129    149       C4-type 3 (Potential).
FT   ZN_FING     175    189       C4-type 4 (Potential).
FT   MOTIF         3     11       Nuclear localization signal (Potential).
FT   COMPBIAS    269    286       Asp/Glu-rich (acidic).
FT   MOD_RES     308    308       Phosphotyrosine.
FT   MOD_RES     315    315       Phosphotyrosine.
FT   VARIANT      28     28       T -> A (in dbSNP:rs35353789).
FT                                /FTId=VAR_051500.
FT   VARIANT     298    298       L -> M (in dbSNP:rs34631212).
FT                                /FTId=VAR_051501.
SQ   SEQUENCE   320 AA;  36201 MW;  CC7F03EE70BF8FD1 CRC64;
     MPKKKTGARK KAENRREREK QLRASRSTID LAKHPCNASM ECDKCQRRQK NRAFCYFCNS
     VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI CDFCEAWVCH GRKCLSTHAC
     ACPLTDAECV ECERGVWDHG GRIFSCSFCH NFLCEDDQFE HQASCQVLEA ETFKCVSCNR
     LGQHSCLRCK ACFCDDHTRS KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG
     GEEGDGASGY DAYWKNLSSD KYGDTSYHDE EEDEYEAEDD EEEEDEGRKD SDTESSDLFT
     NLNLGRTYAS GYAHYEEQEN
//