ID   ZN219_HUMAN             Reviewed;         722 AA.
AC   Q9P2Y4; Q8IYC1; Q9BW28;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 2.
DT   05-OCT-2010, entry version 91.
DE   RecName: Full=Zinc finger protein 219;
GN   Name=ZNF219;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC   TISSUE=Testis;
RX   MEDLINE=20277481; PubMed=10819330; DOI=10.1093/dnares/7.2.137;
RA   Sakai T., Toyoda A., Hashimoto K., Maeda H.;
RT   "Isolation and characterization of a novel zinc finger gene, ZNF219,
RT   and mapping to the human chromosome 14q11 region.";
RL   DNA Res. 7:137-141(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA   Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in
RT   signaling networks.";
RL   Cell 127:635-648(2006).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 6 C2H2-type zinc fingers.
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DR   EMBL; AB015427; BAA90526.1; -; mRNA.
DR   EMBL; BC000694; AAH00694.1; -; mRNA.
DR   EMBL; BC036105; AAH36105.1; -; mRNA.
DR   IPI; IPI00002612; -.
DR   RefSeq; NP_001095142.1; -.
DR   RefSeq; NP_001095924.1; -.
DR   RefSeq; NP_057507.2; -.
DR   UniGene; Hs.250493; -.
DR   ProteinModelPortal; Q9P2Y4; -.
DR   SMR; Q9P2Y4; 54-325, 273-555.
DR   STRING; Q9P2Y4; -.
DR   PhosphoSite; Q9P2Y4; -.
DR   PRIDE; Q9P2Y4; -.
DR   Ensembl; ENST00000360947; ENSP00000354206; ENSG00000165804.
DR   Ensembl; ENST00000421093; ENSP00000392401; ENSG00000165804.
DR   Ensembl; ENST00000451119; ENSP00000388558; ENSG00000165804.
DR   GeneID; 51222; -.
DR   KEGG; hsa:51222; -.
DR   UCSC; uc001vzr.2; human.
DR   CTD; 51222; -.
DR   GeneCards; GC14M021558; -.
DR   HGNC; HGNC:13011; ZNF219.
DR   MIM; 605036; gene.
DR   PharmGKB; PA37590; -.
DR   HOGENOM; HBG716587; -.
DR   HOVERGEN; HBG054187; -.
DR   InParanoid; Q9P2Y4; -.
DR   OMA; ADASPPY; -.
DR   OrthoDB; EOG91G5PC; -.
DR   PhylomeDB; Q9P2Y4; -.
DR   NextBio; 54298; -.
DR   ArrayExpress; Q9P2Y4; -.
DR   Bgee; Q9P2Y4; -.
DR   CleanEx; HS_ZNF219; -.
DR   Genevestigator; Q9P2Y4; -.
DR   GermOnline; ENSG00000165804; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0004969; F:histamine receptor activity; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0003700; F:transcription factor activity; IDA:UniProtKB.
DR   GO; GO:0016564; F:transcription repressor activity; IDA:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-dependent; IDA:UniProtKB.
DR   InterPro; IPR003980; Histamine_H3_recept.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 2.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   PRINTS; PR01471; HISTAMINEH3R.
DR   SMART; SM00355; ZnF_C2H2; 9.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   1: Evidence at protein level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Phosphoprotein; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    722       Zinc finger protein 219.
FT                                /FTId=PRO_0000047461.
FT   ZN_FING      57     79       C2H2-type 1.
FT   ZN_FING      85    107       C2H2-type 2.
FT   ZN_FING     163    186       C2H2-type 3.
FT   ZN_FING     274    296       C2H2-type 4.
FT   ZN_FING     302    324       C2H2-type 5.
FT   ZN_FING     498    520       C2H2-type 6.
FT   MOD_RES     175    175       Phosphoserine.
FT   CONFLICT    232    233       Missing (in Ref. 2; AAH00694).
FT   CONFLICT    260    260       P -> T (in Ref. 2; AAH36105).
FT   CONFLICT    436    436       E -> Q (in Ref. 1; BAA90526).
SQ   SEQUENCE   722 AA;  76877 MW;  AB2B6B37904FC14B CRC64;
     MEGSRPRAPS GHLAPSPPAF DGELDLQRYS NGPAVSAGSL GMGAVSWSES RAGERRFPCP
     VCGKRFRFNS ILALHLRAHP GAQAFQCPHC GHRAAQRALL RSHLRTHQPE RPRSPAARLL
     LELEERALLR EARLGRARSS GGMQATPATE GLARPQAPSS SAFRCPYCKG KFRTSAERER
     HLHILHRPWK CGLCSFGSSQ EEELLHHSLT AHGAPERPLA ATSAAPPPQP QPQPPPQPEP
     RSVPQPEPEP EPEREATPTP APAAPEEPPA PPEFRCQVCG QSFTQSWFLK GHMRKHKASF
     DHACPVCGRC FKEPWFLKNH MKVHASKLGP LRAPGPASGP ARAPQPPDLG LLAYEPLGPA
     LLLAPAPTPA ERREPPSLLG YLSLRAGEGR PNGEGAEPGP GRSFGGFRPL SSALPARARR
     HRAEEPEEEE EVVEAEEETW ARGRSLGSLA SLHPRPGEGP GHSASAAGAQ ARSTATQEEN
     GLLVGGTRPE GGRGATGKDC PFCGKSFRSA HHLKVHLRVH TGERPYKCPH CDYAGTQSGS
     LKYHLQRHHR EQRSGAGPGP PPEPPPPSQR GSAPQSGAKP SPQPATWVEG ASSPRPPSSG
     AGPGSRRKPA SPGRTLRNGR GGEAEPLDLS LRAGPGGEAG PGGALHRCLF CPFATGAPEL
     MALHLQVHHS RRARGRRPPQ ADASPPYARV PSGETPPSPS QEGEEGSGLS RPGEAGLGGQ
     ER
//