ID   ZFP42_HUMAN             Reviewed;         310 AA.
AC   Q96MM3; D3DP65; Q8WXE2;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   05-OCT-2010, entry version 70.
DE   RecName: Full=Zinc finger protein 42 homolog;
DE            Short=Zfp-42;
DE   AltName: Full=Reduced expression protein 1;
DE            Short=REX-1;
DE            Short=hREX-1;
DE   AltName: Full=Zinc finger protein 754;
GN   Name=ZFP42; Synonyms=REX1, ZNF754;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   MEDLINE=22107576; PubMed=12110702;
RA   Henderson J.K., Draper J.S., Baillie H.S., Fishel S., Thomson J.A.,
RA   Moore H., Andrews P.W.;
RT   "Preimplantation human embryos and embryonic stem cells show
RT   comparable expression of stage-specific embryonic antigens.";
RL   Stem Cells 20:329-337(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RA   Clapp J., Hewitt J.E.;
RT   "A survey of transcripts in the 4q35 FSHD region.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   TISSUE SPECIFICITY.
RX   PubMed=16424014; DOI=10.1158/0008-5472.CAN-05-2445;
RA   Korkola J.E., Houldsworth J., Chadalavada R.S., Olshen A.B.,
RA   Dobrzynski D., Reuter V.E., Bosl G.J., Chaganti R.S.;
RT   "Down-regulation of stem cell genes, including those in a 200-kb gene
RT   cluster at 12p13.31, is associated with in vivo differentiation of
RT   human male germ cell tumors.";
RL   Cancer Res. 66:820-827(2006).
RN   [7]
RP   INDUCTION, AND TISSUE SPECIFICITY.
RX   PubMed=16344273; DOI=10.1093/carcin/bgi299;
RA   Raman J.D., Mongan N.P., Liu L., Tickoo S.K., Nanus D.M., Scherr D.S.,
RA   Gudas L.J.;
RT   "Decreased expression of the human stem cell marker, Rex-1 (zfp-42),
RT   in renal cell carcinoma.";
RL   Carcinogenesis 27:499-507(2006).
RN   [8]
RP   TISSUE SPECIFICITY.
RX   PubMed=16865673; DOI=10.1002/mc.20186;
RA   Mongan N.P., Martin K.M., Gudas L.J.;
RT   "The putative human stem cell marker, Rex-1 (Zfp42): structural
RT   classification and expression in normal human epithelial and carcinoma
RT   cell cultures.";
RL   Mol. Carcinog. 45:887-900(2006).
CC   -!- FUNCTION: Involved in self-renewal property of ES cells (By
CC       similarity). May be involved in transcriptional regulation (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed in kidney, epidermal keratinocytes,
CC       prostate epithelial cells, bronchial and small airway lung
CC       epithelial cells (at protein level). Expressed in malignant kidney
CC       and several carcinoma cell lines (at protein level). Expressed in
CC       embryonic stem cells, kidney, epidermal keratinocytes, prostate
CC       epithelial cells, bronchial and small airway lung epithelial
CC       cells. Expressed in embryonal carcinomas, seminomas, malignant
CC       kidney and several carcinoma cell lines.
CC   -!- INDUCTION: Down-regulated upon retinoic acid addition to F9 stem
CC       cells.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 4 C2H2-type zinc fingers.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF450454; AAL47167.1; -; mRNA.
DR   EMBL; AY429593; AAR07993.1; -; mRNA.
DR   EMBL; AK056719; BAB71264.1; -; mRNA.
DR   EMBL; AC108073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471056; EAX04610.1; -; Genomic_DNA.
DR   EMBL; CH471056; EAX04611.1; -; Genomic_DNA.
DR   EMBL; CH471056; EAX04612.1; -; Genomic_DNA.
DR   IPI; IPI00292080; -.
DR   RefSeq; NP_777560.2; -.
DR   UniGene; Hs.335787; -.
DR   HSSP; P25490; 1ZNM.
DR   ProteinModelPortal; Q96MM3; -.
DR   SMR; Q96MM3; 188-300.
DR   STRING; Q96MM3; -.
DR   PRIDE; Q96MM3; -.
DR   Ensembl; ENST00000326866; ENSP00000317686; ENSG00000179059.
DR   GeneID; 132625; -.
DR   KEGG; hsa:132625; -.
DR   UCSC; uc003izg.1; human.
DR   CTD; 132625; -.
DR   GeneCards; GC04P188916; -.
DR   HGNC; HGNC:30949; ZFP42.
DR   HPA; CAB025557; -.
DR   PharmGKB; PA142670530; -.
DR   eggNOG; prNOG05253; -.
DR   HOGENOM; HBG127054; -.
DR   HOVERGEN; HBG006823; -.
DR   InParanoid; Q96MM3; -.
DR   NextBio; 83110; -.
DR   ArrayExpress; Q96MM3; -.
DR   Bgee; Q96MM3; -.
DR   CleanEx; HS_ZFP42; -.
DR   Genevestigator; Q96MM3; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0008585; P:female gonad development; IEP:UniProtKB.
DR   GO; GO:0008584; P:male gonad development; IEP:UniProtKB.
DR   GO; GO:0007126; P:meiosis; NAS:UniProtKB.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 2.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   1: Evidence at protein level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    310       Zinc finger protein 42 homolog.
FT                                /FTId=PRO_0000287289.
FT   ZN_FING     188    212       C2H2-type 1.
FT   ZN_FING     217    239       C2H2-type 2.
FT   ZN_FING     245    269       C2H2-type 3.
FT   ZN_FING     275    299       C2H2-type 4.
FT   CONFLICT     88     88       E -> G (in Ref. 2; AAR07993 and 3;
FT                                BAB71264).
SQ   SEQUENCE   310 AA;  34802 MW;  FBF4D7470DC37325 CRC64;
     MSQQLKKRAK TRHQKGLGGR APSGAKPRQG KSSQDLQAEI EPVSAVWALC DGYVCYEPGP
     QALGGDDFSD CYIECVIRGE FSQPILEEDS LFESLEYLKK GSEQQLSQKV FEASSLECSL
     EYMKKGVKKE LPQKIVGENS LEYSEYMTGK KLPPGGIPGI DLSDPKQLAE FARKKPPINK
     EYDSLSAIAC PQSGCTRKLR NRAALRKHLL IHGPRDHVCA ECGKAFVESS KLKRHFLVHT
     GEKPFRCTFE GCGKRFSLDF NLRTHVRIHT GEKRFVCPFQ GCNRRFIQSN NLKAHILTHA
     NTNKNEQEGK
//