ID ZC3HF_HUMAN Reviewed; 426 AA. AC Q8WU90; Q5QTQ4; Q8WZ06; Q9NUZ3; Q9NZ37; Q9P079; DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2002, sequence version 1. DT 05-OCT-2010, entry version 62. DE RecName: Full=Zinc finger CCCH domain-containing protein 15; DE AltName: Full=DRG family-regulatory protein 1; DE AltName: Full=Likely ortholog of mouse immediate early response erythropoietin 4; GN Name=ZC3H15; Synonyms=DFRP1, LEREPO4; GN ORFNames=HSPC303, HT010, MSTP012, PP730; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Aorta; RA Hui R.T., Liu Y.Q., Liu B., Zhao B., Meng X.M., Sheng H., Xu Y.Y., RA Wang X.Y., Ye J., Song L., Gao Y., Wei Y.J., Zhang C.L., Zhang J., RA Chai M.Q., Chen J.Z., Sun Y.H., Zhou X.L., Jiang Y.X., Zhao X.W., RA Liu S., Cao H.Q., Zhao Y., Liu D.Q., Ding J.F., Liu L.S., Gao R.L., RA Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S.; RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Umbilical cord blood; RA Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., RA Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.; RT "Human partial CDS from CD34+ stem cells."; RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Hypothalamus; RX MEDLINE=20402571; PubMed=10931946; DOI=10.1073/pnas.160270997; RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., RA Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., RA Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., RA Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.; RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal RT axis and full-length cDNA cloning."; RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15498874; DOI=10.1073/pnas.0404089101; RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., RA Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., RA Shu H., Chen X., Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., RA Gu J.; RT "Large-scale cDNA transfection screening for genes related to cancer RT development and progression."; RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Muscle; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] RP INTERACTION WITH DRG1, AND SUBCELLULAR LOCATION. RX PubMed=15676025; DOI=10.1111/j.1365-2443.2005.00825.x; RA Ishikawa K., Azuma S., Ikawa S., Semba K., Inoue J.; RT "Identification of DRG family regulatory proteins (DFRPs): specific RT regulation of DRG1 and DRG2."; RL Genes Cells 10:139-150(2005). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-381, AND MASS RP SPECTROMETRY. RC TISSUE=Cervix carcinoma; RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026; RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., RA Mann M.; RT "Global, in vivo, and site-specific phosphorylation dynamics in RT signaling networks."; RL Cell 127:635-648(2006). RN [11] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RA Colinge J., Superti-Furga G., Bennett K.L.; RL Submitted (OCT-2008) to UniProtKB. RN [12] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-351, AND MASS RP SPECTROMETRY. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). CC -!- FUNCTION: Protects DRG1 from proteolytic degradation (By CC similarity). CC -!- SUBUNIT: Interacts with DRG1. CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). CC -!- SIMILARITY: Belongs to the ZC3H15/TMA46 family. CC -!- SIMILARITY: Contains 2 C3H1-type zinc fingers. CC -!- SEQUENCE CAUTION: CC Sequence=AAF28981.1; Type=Frameshift; Positions=17; CC Sequence=AAF67649.1; Type=Frameshift; Positions=392, 407, 422; CC Sequence=AAL55770.1; Type=Frameshift; Positions=92; CC Sequence=AAQ13514.1; Type=Frameshift; Positions=404, 424; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF109366; AAQ13514.1; ALT_FRAME; mRNA. DR EMBL; AF161421; AAF28981.1; ALT_FRAME; mRNA. DR EMBL; AF220184; AAF67649.1; ALT_FRAME; mRNA. DR EMBL; AK001901; BAA91968.1; -; mRNA. DR EMBL; AF289586; AAL55770.1; ALT_FRAME; mRNA. DR EMBL; AC018867; AAX88885.1; -; Genomic_DNA. DR EMBL; CH471058; EAX10935.1; -; Genomic_DNA. DR EMBL; BC021102; AAH21102.1; -; mRNA. DR IPI; IPI00000279; -. DR RefSeq; NP_060941.2; -. DR UniGene; Hs.724407; -. DR ProteinModelPortal; Q8WU90; -. DR SMR; Q8WU90; 100-213. DR IntAct; Q8WU90; 1. DR STRING; Q8WU90; -. DR PhosphoSite; Q8WU90; -. DR PRIDE; Q8WU90; -. DR Ensembl; ENST00000337859; ENSP00000338788; ENSG00000065548. DR GeneID; 55854; -. DR KEGG; hsa:55854; -. DR UCSC; uc002upo.1; human. DR CTD; 55854; -. DR GeneCards; GC02P187350; -. DR H-InvDB; HIX0002656; -. DR HGNC; HGNC:29528; ZC3H15. DR HPA; HPA031099; -. DR HPA; HPA031100; -. DR HPA; HPA031101; -. DR eggNOG; prNOG19745; -. DR HOGENOM; HBG737197; -. DR HOVERGEN; HBG108761; -. DR InParanoid; Q8WU90; -. DR OMA; EKDTMEN; -. DR OrthoDB; EOG90GG99; -. DR PhylomeDB; Q8WU90; -. DR NextBio; 61127; -. DR ArrayExpress; Q8WU90; -. DR Bgee; Q8WU90; -. DR CleanEx; HS_ZC3H15; -. DR Genevestigator; Q8WU90; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR InterPro; IPR000571; Znf_CCCH. DR Pfam; PF00642; zf-CCCH; 1. DR SMART; SM00356; ZnF_C3H1; 2. DR PROSITE; PS50103; ZF_C3H1; 2. PE 1: Evidence at protein level; KW Coiled coil; Complete proteome; Cytoplasm; Metal-binding; Nucleus; KW Phosphoprotein; Polymorphism; Repeat; Zinc; Zinc-finger. FT CHAIN 1 426 Zinc finger CCCH domain-containing FT protein 15. FT /FTId=PRO_0000324642. FT ZN_FING 99 126 C3H1-type 1. FT ZN_FING 174 212 C3H1-type 2. FT REGION 236 260 Required for interaction with DRG1 (By FT similarity). FT COILED 61 86 Potential. FT COILED 218 285 Potential. FT MOD_RES 351 351 Phosphoserine. FT MOD_RES 381 381 Phosphoserine. FT VARIANT 342 342 V -> E (in dbSNP:rs11555006). FT /FTId=VAR_039867. FT VARIANT 408 408 T -> P (in dbSNP:rs1043497). FT /FTId=VAR_052969. FT CONFLICT 10 10 G -> R (in Ref. 5; AAL55770). FT CONFLICT 16 17 EQ -> DE (in Ref. 3; AAF67649). FT CONFLICT 17 17 Q -> T (in Ref. 2; AAF28981). FT CONFLICT 26 26 D -> G (in Ref. 5; AAL55770). FT CONFLICT 37 37 A -> T (in Ref. 5; AAL55770). FT CONFLICT 77 77 E -> D (in Ref. 2; AAF28981 and 3; FT AAF67649). FT CONFLICT 112 112 Q -> R (in Ref. 4; BAA91968). FT CONFLICT 342 342 V -> A (in Ref. 2; AAF28981). FT CONFLICT 365 365 N -> T (in Ref. 2; AAF28981). FT CONFLICT 413 413 D -> V (in Ref. 1; AAQ13514). SQ SEQUENCE 426 AA; 48602 MW; 4A80B7FDC3376181 CRC64; MPPKKQAQAG GSKKAEQKKK EKIIEDKTFG LKNKKGAKQQ KFIKAVTHQV KFGQQNPRQV AQSEAEKKLK KDDKKKELQE LNELFKPVVA AQKISKGADP KSVVCAFFKQ GQCTKGDKCK FSHDLTLERK CEKRSVYIDA RDEELEKDTM DNWDEKKLEE VVNKKHGEAE KKKPKTQIVC KHFLEAIENN KYGWFWVCPG GGDICMYRHA LPPGFVLKKD KKKEEKEDEI SLEDLIERER SALGPNVTKI TLESFLAWKK RKRQEKIDKL EQDMERRKAD FKAGKALVIS GREVFEFRPE LVNDDDEEAD DTRYTQGTGG DEVDDSVSVN DIDLSLYIPR DVDETGITVA SLERFSTYTS DKDENKLSEA SGGRAENGER SDLEEDNERE GTENGAIDAV PVDENLFTGE DLDELEEELN TLDLEE //