ID   ZBTB4_HUMAN             Reviewed;        1013 AA.
AC   Q9P1Z0; B3KVL6; Q7Z697; Q86XJ4; Q8N4V8;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 3.
DT   05-OCT-2010, entry version 77.
DE   RecName: Full=Zinc finger and BTB domain-containing protein 4;
DE   AltName: Full=KAISO-like zinc finger protein 1;
DE            Short=KAISO-L1;
GN   Name=ZBTB4; Synonyms=KIAA1538;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fetal brain;
RA   Weber A., Klinkhammer B., Glaum A., Bergmann E., Berwanger B.,
RA   Eilers M., Christiansen H.;
RT   "Identification of a novel zinc-finger-protein encoding gene on
RT   17p13.1.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=20277482; PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA   Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XVII.
RT   The complete sequences of 100 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 7:143-150(2000).
RN   [3]
RP   SEQUENCE REVISION.
RX   MEDLINE=22158633; PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA   Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT   "Construction of expression-ready cDNA clones for KIAA genes: manual
RT   curation of 330 KIAA cDNA clones.";
RL   DNA Res. 9:99-106(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- SIMILARITY: Contains 1 BTB (POZ) domain.
CC   -!- SIMILARITY: Contains 6 C2H2-type zinc fingers.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA96062.2; Type=Erroneous initiation;
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DR   EMBL; AY302699; AAP59447.1; -; mRNA.
DR   EMBL; AB040971; BAA96062.2; ALT_INIT; mRNA.
DR   EMBL; AK122971; BAG53828.1; -; mRNA.
DR   EMBL; CH471108; EAW90185.1; -; Genomic_DNA.
DR   EMBL; BC033259; AAH33259.1; -; mRNA.
DR   EMBL; BC043352; AAH43352.1; -; mRNA.
DR   IPI; IPI00001835; -.
DR   RefSeq; NP_001122305.1; -.
DR   RefSeq; NP_065950.2; -.
DR   UniGene; Hs.35096; -.
DR   ProteinModelPortal; Q9P1Z0; -.
DR   SMR; Q9P1Z0; 9-178, 231-388, 305-389, 724-793.
DR   STRING; Q9P1Z0; -.
DR   PhosphoSite; Q9P1Z0; -.
DR   PRIDE; Q9P1Z0; -.
DR   Ensembl; ENST00000311403; ENSP00000307858; ENSG00000174282.
DR   Ensembl; ENST00000380599; ENSP00000369973; ENSG00000174282.
DR   GeneID; 57659; -.
DR   KEGG; hsa:57659; -.
DR   UCSC; uc002ghc.2; human.
DR   CTD; 57659; -.
DR   GeneCards; GC17M007362; -.
DR   H-InvDB; HIX0013496; -.
DR   HGNC; HGNC:23847; ZBTB4.
DR   HPA; CAB008980; -.
DR   MIM; 612308; gene.
DR   PharmGKB; PA134959224; -.
DR   eggNOG; prNOG13694; -.
DR   HOGENOM; HBG755359; -.
DR   HOVERGEN; HBG055508; -.
DR   InParanoid; Q9P1Z0; -.
DR   OMA; ALSRHGQ; -.
DR   OrthoDB; EOG9577RX; -.
DR   PhylomeDB; Q9P1Z0; -.
DR   NextBio; 64421; -.
DR   ArrayExpress; Q9P1Z0; -.
DR   Bgee; Q9P1Z0; -.
DR   CleanEx; HS_ZBTB4; -.
DR   Genevestigator; Q9P1Z0; -.
DR   GermOnline; ENSG00000174282; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045449; P:regulation of transcription; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR000210; BTB/POZ-like.
DR   InterPro; IPR011333; BTB/POZ_fold.
DR   InterPro; IPR013069; BTB_POZ.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   Gene3D; G3DSA:3.30.710.10; BTB/POZ_fold; 1.
DR   Pfam; PF00651; BTB; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   SUPFAM; SSF54695; BTB/POZ_fold; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   1: Evidence at protein level;
KW   Coiled coil; Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Polymorphism; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1   1013       Zinc finger and BTB domain-containing
FT                                protein 4.
FT                                /FTId=PRO_0000047712.
FT   DOMAIN       30    152       BTB.
FT   ZN_FING     234    256       C2H2-type 1; atypical.
FT   ZN_FING     309    331       C2H2-type 2.
FT   ZN_FING     337    359       C2H2-type 3.
FT   ZN_FING     365    388       C2H2-type 4.
FT   ZN_FING     726    748       C2H2-type 5.
FT   ZN_FING     765    787       C2H2-type 6.
FT   COILED      627    663       Potential.
FT   COMPBIAS    435    536       Pro-rich.
FT   COMPBIAS    610    654       Glu-rich.
FT   VARIANT     539    539       A -> V (in dbSNP:rs35231078).
FT                                /FTId=VAR_052913.
FT   VARIANT     550    550       M -> I (in dbSNP:rs871990).
FT                                /FTId=VAR_018383.
FT   VARIANT     561    561       N -> S (in dbSNP:rs34914463).
FT                                /FTId=VAR_052914.
FT   CONFLICT    188    188       P -> S (in Ref. 6; AAH43352).
FT   CONFLICT    674    674       R -> C (in Ref. 6; AAH43352).
SQ   SEQUENCE   1013 AA;  105114 MW;  CA4AB6A5230C2F52 CRC64;
     MPPPAEVTDP SHAPAVLRQL NEQRLRGLFC DVTLIAGDTK FPAHRSVLAA SSPFFREALL
     TSAPLPLPPA TGGAAPNPAT TTAASSSSSS SSSSSSSSSS ASSSSSSSSS SPPPASPPAS
     SPPRVLELPG VPAAAFSDVL NFIYSARLAL PGGGGDGAAV AEIGALGRRL GISRLQGLGE
     GGDAWVPPTP APMATSQPEE DSFGPGPRPA GEWEGDRAEA QAPDLQCSLP RRPLPCPQCG
     KSFIHPKRLQ THEAQCRRGA STRGSTGLGA GGAGPGGPAG VDASALPPPV GFRGGPEHVV
     KVVGGHVLYV CAACERSYVT LSSLKRHSNV HSWRRKYPCR YCEKVFALAE YRTKHEVWHT
     GERRYQCIFC WETFVTYYNL KTHQRAFHGI SPGLLASEKT PNGGYKPKLN TLKLYRLLPM
     RAAKRPYKTY SQGAPEAPLS PTLNTPAPVA MPASPPPGPP PAPEPGPPPS VITFAHPAPS
     VIVHGGSSSG GGGSGTASTG GSQAASVITY TAPPRPPKKR EYPPPPPEPA ATPTSPATAV
     SPATAAGPAM ATTTEEAKGR NPRAGRTLTY TAKPVGGIGG GGGPPTGAGR GPSQLQAPPP
     LCQITVRIGE EAIVKRRISE TDLRPGELSG EEMEESEEDE EEEDEEEEEE DEEESKAGGE
     DQLWRPYYSY KPKRKAGAAG GASVGGSGLP RGRRPPRWRQ KLERRSWEET PAAESPAGRA
     RTERRHRCGD CAQTFTTLRK LRKHQEAHGG GSHSSRAGRR PSTRFTCPHC AKVCKTAAAL
     SRHGQRHAAE RPGGTPTPVI AYSKGSAGTR PGDVKEEAPQ EMQVSSSSGE AGGGSTAAEE
     ASETASLQDP IISGGEEPPV VASGGSYVYP PVQEFPLALI GGGREPGGGR GKSGSEGPVG
     AGEGDRMEGI GAAKVTFYPE PYPLVYGPQL LAAYPYNFSN LAALPVALNM VLPDEKGAGA
     LPFLPGVFGY AVNPQAAPPA PPTPPPPTLP PPIPPKGEGE RAGVERTQKG DVG
//