ID   U2AFL_HUMAN             Reviewed;         479 AA.
AC   Q15695; B2R901; Q13570; Q2M3R8;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   05-OCT-2010, entry version 86.
DE   RecName: Full=U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1;
DE   AltName: Full=CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1;
DE   AltName: Full=U2(RNU2) small nuclear RNA auxiliary factor 1-like 1;
GN   Name=ZRSR1; Synonyms=U2AF1-RS1, U2AF1L1, U2AF1P, U2AF1RS1, U2AFBPL;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=96163878; PubMed=8586425; DOI=10.1006/geno.1995.9879;
RA   Kitagawa K., Wang X., Hatada I., Yamaoka T., Nojima H., Inazawa J.,
RA   Abe T., Mitsuya K., Oshimura M., Murata A., Monden M., Mukai T.;
RT   "Isolation and mapping of human homologues of an imprinted mouse gene
RT   U2af1-rs1.";
RL   Genomics 30:257-263(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=96212931; PubMed=8630064; DOI=10.1006/bbrc.1996.0716;
RA   Pearsall R.S., Shibata H., Brozowska A., Yoshino K., Okuda K.,
RA   Dejong P.J., Plass C., Chapman V.M., Hayashizaki Y., Held W.A.;
RT   "Absence of imprinting in U2AFBPL, a human homologue of the imprinted
RT   mouse gene U2afbp-rs.";
RL   Biochem. Biophys. Res. Commun. 222:171-177(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- SIMILARITY: Contains 2 C3H1-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
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DR   EMBL; D49676; BAA08532.1; -; mRNA.
DR   EMBL; U51224; AAA98669.1; -; Genomic_DNA.
DR   EMBL; AK313576; BAG36348.1; -; mRNA.
DR   IPI; IPI00018952; -.
DR   UniGene; Hs.637001; -.
DR   ProteinModelPortal; Q15695; -.
DR   SMR; Q15695; 202-308.
DR   STRING; Q15695; -.
DR   PRIDE; Q15695; -.
DR   Ensembl; ENST00000391338; ENSP00000375133; ENSG00000212643.
DR   UCSC; uc003kqd.2; human.
DR   GeneCards; GC05P112228; -.
DR   H-InvDB; HIX0017758; -.
DR   HGNC; HGNC:12456; ZRSR1.
DR   MIM; 601079; gene.
DR   eggNOG; prNOG19602; -.
DR   HOGENOM; HBG525917; -.
DR   HOVERGEN; HBG054605; -.
DR   InParanoid; Q15695; -.
DR   OMA; ERLHEEW; -.
DR   OrthoDB; EOG9Q5C80; -.
DR   PhylomeDB; Q15695; -.
DR   ArrayExpress; Q15695; -.
DR   Bgee; Q15695; -.
DR   Genevestigator; Q15695; -.
DR   GermOnline; ENSG00000174044; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; NAS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR012677; a_b_plait_nuc-bd.
DR   InterPro; IPR000504; RRM_RNP1.
DR   InterPro; IPR009145; U2_small.
DR   InterPro; IPR000571; Znf_CCCH.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   PANTHER; PTHR12620; U2_small; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   Pfam; PF00642; zf-CCCH; 1.
DR   PRINTS; PR01848; U2AUXFACTOR.
DR   SMART; SM00360; RRM; 1.
DR   SMART; SM00356; ZnF_C3H1; 2.
DR   PROSITE; PS50102; RRM; 1.
DR   PROSITE; PS50103; ZF_C3H1; 2.
PE   2: Evidence at transcript level;
KW   Complete proteome; Metal-binding; Nucleus; Polymorphism; Repeat;
KW   Ribonucleoprotein; RNA-binding; Zinc; Zinc-finger.
FT   CHAIN         1    479       U2 small nuclear ribonucleoprotein
FT                                auxiliary factor 35 kDa subunit-related
FT                                protein 1.
FT                                /FTId=PRO_0000081999.
FT   DOMAIN      203    309       RRM.
FT   ZN_FING     171    199       C3H1-type 1.
FT   ZN_FING     311    338       C3H1-type 2.
FT   VARIANT     155    155       S -> G (in dbSNP:rs712665).
FT                                /FTId=VAR_021999.
FT   VARIANT     444    444       S -> N (in dbSNP:rs430665).
FT                                /FTId=VAR_024622.
FT   CONFLICT    135    135       K -> E (in Ref. 3; BAG36348).
FT   CONFLICT    195    195       K -> R (in Ref. 3; BAG36348).
SQ   SEQUENCE   479 AA;  57643 MW;  96F326694BD4E7C0 CRC64;
     MAALEKMTFP KKMTFPEKPS HKKYRAALKK EKRKKRRQEL ARLRDSGLSQ EEEEDTFIEE
     QQLEEEKLLE RERERLHEEW LLREQKAQEE FRIKKEKEEA AKKWLEEQER KLKEQWKEQQ
     RKEREEEEQK QQEKKEKEEA VQKMLDQAEN DLENSTTWQN PEPPVDFRVM EKDRANCPFY
     SKTGACRFGD RCSRKHNFPT SSPTLLIKSM FTTFGMEQCR RDDYDPDASL EYSEEETYQQ
     FLDFYEDVLP EFKNVGKVIQ FKVSCNLEPH LRGNVYVQYQ SEEECQAALS LFNGRWYAGR
     QLQCEFCPVT RWKMAICGLF EIQQCPRGKH CNFLHVFRNP NNEFWEANRD IYLSSDQTGS
     SFGKNSERRE KMGHHDHYYS RQRGRRNPSP DHTYKRNGES ERKKSSHRGK KSHKRTSKSR
     ERHNSPSRGR NRHRSWDQGR RSQSRRSHRS RSQSSSRCRS RGRRKSGNRD RTVQSPQSK
//