ID   TSR1_HUMAN              Reviewed;         804 AA.
AC   Q2NL82; Q8WUY5; Q9NVT0; Q9P2E6;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   05-OCT-2010, entry version 53.
DE   RecName: Full=Pre-rRNA-processing protein TSR1 homolog;
GN   Name=TSR1; Synonyms=KIAA1401;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=20181126; PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA   Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XVI.
RT   The complete sequences of 150 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 7:65-73(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-386.
RC   TISSUE=Brain, and Lymph;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PROTEIN SEQUENCE OF 79-106; 140-151; 220-234; 251-273; 480-492;
RP   518-537; 625-637 AND 721-732, AND MASS SPECTROMETRY.
RC   TISSUE=Hepatoma;
RA   Bienvenut W.V., Boldt K., von Kriegsheim A.F., Kolch W.;
RL   Submitted (JUL-2007) to UniProtKB.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 135-804.
RC   TISSUE=Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-475, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA   Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in
RT   signaling networks.";
RL   Cell 127:635-648(2006).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RA   Colinge J., Superti-Furga G., Bennett K.L.;
RL   Submitted (OCT-2008) to UniProtKB.
CC   -!- FUNCTION: Required during maturation of the 40S ribosomal subunit
CC       in the nucleolus (By similarity).
CC   -!- INTERACTION:
CC       O60739:EIF1B; NbExp=1; IntAct=EBI-358058, EBI-1043343;
CC       Q9NX58:LYAR; NbExp=1; IntAct=EBI-358058, EBI-713507;
CC       O75940:SMNDC1; NbExp=1; IntAct=EBI-358058, EBI-1052641;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus (By similarity).
CC   -!- SIMILARITY: Belongs to the BMS1/TSR1 family. TSR1 subfamily.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA91667.1; Type=Erroneous initiation;
CC       Sequence=BAA92639.1; Type=Erroneous initiation;
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DR   EMBL; AB037822; BAA92639.1; ALT_INIT; mRNA.
DR   EMBL; CH471108; EAW90552.1; -; Genomic_DNA.
DR   EMBL; BC019090; AAH19090.2; -; mRNA.
DR   EMBL; BC110851; AAI10852.1; -; mRNA.
DR   EMBL; BC126110; AAI26111.1; -; mRNA.
DR   EMBL; AK001396; BAA91667.1; ALT_INIT; mRNA.
DR   IPI; IPI00292894; -.
DR   RefSeq; NP_060598.3; -.
DR   UniGene; Hs.388170; -.
DR   UniGene; Hs.461954; -.
DR   ProteinModelPortal; Q2NL82; -.
DR   IntAct; Q2NL82; 8.
DR   MINT; MINT-4860330; -.
DR   STRING; Q2NL82; -.
DR   PhosphoSite; Q2NL82; -.
DR   PeptideAtlas; Q2NL82; -.
DR   PRIDE; Q2NL82; -.
DR   Ensembl; ENST00000301364; ENSP00000301364; ENSG00000167721.
DR   GeneID; 55720; -.
DR   KEGG; hsa:55720; -.
DR   NMPDR; fig|9606.3.peg.12849; -.
DR   UCSC; uc002fuj.1; human.
DR   CTD; 55720; -.
DR   GeneCards; GC17M002173; -.
DR   H-InvDB; HIX0013417; -.
DR   HGNC; HGNC:25542; TSR1.
DR   HPA; HPA024434; -.
DR   MIM; 611214; gene.
DR   PharmGKB; PA31821; -.
DR   eggNOG; prNOG13151; -.
DR   HOGENOM; HBG330634; -.
DR   HOVERGEN; HBG099515; -.
DR   InParanoid; Q2NL82; -.
DR   OMA; GTSEYQA; -.
DR   OrthoDB; EOG9GQSRH; -.
DR   PhylomeDB; Q2NL82; -.
DR   NextBio; 60619; -.
DR   PMAP-CutDB; Q2NL82; -.
DR   ArrayExpress; Q2NL82; -.
DR   Bgee; Q2NL82; -.
DR   CleanEx; HS_TSR1; -.
DR   Genevestigator; Q2NL82; -.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0042255; P:ribosome assembly; ISS:UniProtKB.
DR   InterPro; IPR012948; AARP2CN.
DR   InterPro; IPR007034; BMS1_TSR1_C.
DR   Pfam; PF08142; AARP2CN; 1.
DR   Pfam; PF04950; DUF663; 1.
DR   SMART; SM00785; AARP2CN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein;
KW   Polymorphism; Ribosome biogenesis.
FT   CHAIN         1    804       Pre-rRNA-processing protein TSR1 homolog.
FT                                /FTId=PRO_0000311274.
FT   COMPBIAS    415    487       Glu-rich.
FT   MOD_RES     475    475       Phosphotyrosine.
FT   VARIANT     386    386       S -> G (in dbSNP:rs2281726).
FT                                /FTId=VAR_037211.
FT   VARIANT     719    719       N -> S (in dbSNP:rs2273983).
FT                                /FTId=VAR_037212.
FT   VARIANT     727    727       K -> Q (in dbSNP:rs35019711).
FT                                /FTId=VAR_037213.
FT   VARIANT     750    750       H -> Q (in dbSNP:rs35343613).
FT                                /FTId=VAR_037214.
FT   CONFLICT    350    350       G -> C (in Ref. 5; BAA91667).
FT   CONFLICT    737    737       R -> W (in Ref. 1; BAA92639).
SQ   SEQUENCE   804 AA;  91810 MW;  EDDBE6AD04E7F3A7 CRC64;
     MAAHRPGPLK QQNKAHKGGR HRGRGSAQRD GKGRLALKTL SKKVRKELSR VDQRHRASQL
     RKQKKEAVLA EKRQLGGKDG PPHQVLVVPL HSRISLPEAM QLLQDRDTGT VHLNELGNTQ
     NFMLLCPRLK HRWFFTSARP GDLHVVLDMA KVADTILFLL DPLEGWDSTG DYCLSCLFAQ
     GLPTYTLAVQ GISGLPLKKQ IDTRKKLSKA VEKRFPHDKL LLLDTQQEAG MLLRQLANQK
     QQHLAFRDRR AYLFAHAVDF VPSEENNLVG TLKISGYVRG QTLNVNRLLH IVGYGDFQMK
     QIDAPGDPFP LNPRGIKPQK DPDMAMEICA TDAVDDMEEG LKVLMKADPG RQESLQAEVI
     PDPMEGEQTW PTEEELSEAK DFLKESSKVV KKVPKGTSSY QAEWILDGGS QSGGEGDEYE
     YDDMEHEDFM EEESQDESSE EEEEYETMTI GESVHDDLYD KKVDEEAEAK MLEKYKQERL
     EEMFPDEVDT PRDVAARIRF QKYRGLKSFR TSPWDPKENL PQDYARIFQF QNFTNTRKSI
     FKEVEEKEVE GAEVGWYVTL HVSEVPVSVV ECFRQGTPLI AFSLLPHEQK MSVLNMVVRR
     DPGNTEPVKA KEELIFHCGF RRFRASPLFS QHTAADKHKL QRFLTADMAL VATVYAPITF
     PPASVLLFKQ KSNGMHSLIA TGHLMSVDPD RMVIKRVVLS GHPFKIFTKM AVVRYMFFNR
     EDVLWFKPVE LRTKWGRRGH IKEPLGTHGH MKCSFDGKLK SQDTVLMNLY KRVFPKWTYD
     PYVPEPVPWL KSEISSTVPQ GGME
//