ID   TSNA1_HUMAN             Reviewed;         513 AA.
AC   Q96NA8; Q14D03;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   05-OCT-2010, entry version 57.
DE   RecName: Full=t-SNARE domain-containing protein 1;
GN   Name=TSNARE1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LEU-18; PRO-55
RP   AND ALA-118.
RC   TISSUE=Kidney;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (By
CC       similarity).
CC   -!- SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain.
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DR   EMBL; AK055726; BAB70997.1; -; mRNA.
DR   EMBL; BC113556; AAI13557.1; -; mRNA.
DR   IPI; IPI00939874; -.
DR   RefSeq; NP_659440.2; -.
DR   UniGene; Hs.370931; -.
DR   ProteinModelPortal; Q96NA8; -.
DR   SMR; Q96NA8; 253-374, 257-450, 416-482.
DR   IntAct; Q96NA8; 1.
DR   MINT; MINT-6768620; -.
DR   STRING; Q96NA8; -.
DR   Ensembl; ENST00000307180; ENSP00000303437; ENSG00000171045.
DR   GeneID; 203062; -.
DR   KEGG; hsa:203062; -.
DR   UCSC; uc003ywk.1; human.
DR   CTD; 203062; -.
DR   GeneCards; GC08M143292; -.
DR   HGNC; HGNC:26437; TSNARE1.
DR   HPA; HPA015890; -.
DR   PharmGKB; PA142670693; -.
DR   HOVERGEN; HBG079420; -.
DR   InParanoid; Q96NA8; -.
DR   PhylomeDB; Q96NA8; -.
DR   NextBio; 90320; -.
DR   ArrayExpress; Q96NA8; -.
DR   Bgee; Q96NA8; -.
DR   CleanEx; HS_TSNARE1; -.
DR   Genevestigator; Q96NA8; -.
DR   GermOnline; ENSG00000171045; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR010989; t-SNARE.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   Pfam; PF05739; SNARE; 1.
DR   SMART; SM00397; t_SNARE; 1.
DR   SUPFAM; SSF47661; t-snare; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Complete proteome; Membrane; Polymorphism; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    513       t-SNARE domain-containing protein 1.
FT                                /FTId=PRO_0000065668.
FT   TRANSMEM    491    511       Helical; (Potential).
FT   DOMAIN      416    478       t-SNARE coiled-coil homology.
FT   COMPBIAS    503    507       Poly-Ile.
FT   VARIANT      18     18       F -> L (in dbSNP:rs7814359).
FT                                /FTId=VAR_055146.
FT   VARIANT      55     55       R -> P (in dbSNP:rs33970858).
FT                                /FTId=VAR_051461.
FT   VARIANT     118    118       T -> A (in dbSNP:rs10100935).
FT                                /FTId=VAR_051462.
FT   VARIANT     268    268       V -> I (in dbSNP:rs10435683).
FT                                /FTId=VAR_051463.
SQ   SEQUENCE   513 AA;  55949 MW;  415F67290CF97DA8 CRC64;
     MSYGSIARGG GLGSRGPFGG PSRQGCQPLE CARCWTEYGI RHFPCPSPES KLQNRCVGKD
     GEGDLGPAGT PIVPRARKRG PGVAPEGSRM PEPTSSPTIG PRKDSAAGPH GRMAGPSTTR
     AKKRKPNFCP QETEVLVSKV SKHHQLLFGT GLLKAEPTRR YRVWSRILQA VNALGYCRRD
     VVDLKHKWRD LRAVVRRKLG DLRKAAHGPS PGSGKPQALA LTPVEQVVAK TFSCQALPSE
     GFSLEPPRAT QVDPCNLQEL FQEMSANVFR INSSVTSLER SLQSLGTPSD TQELRDSLHT
     AQQETNKTIA ASASSVKQMA ELLRSSCPQE RLQQERPQLD RLKTQLSDAI QCYGVVQKKI
     AEKSRALLPM AQRGSKQSPQ APFAELADDE KVFNGSDNMW QGQEQALLPD ITEEDLEAIR
     LREEAILQME SNLLDVNQII KDLASMVSEQ GEAVDSIEAS LEAASSHAEA ARQLLAGASR
     HQLQRHKIKC CFLSAGVTAL LVIIIIIATS VRK
//