ID TROAP_HUMAN Reviewed; 778 AA. AC Q12815; Q8N5B2; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 10-FEB-2009, sequence version 3. DT 05-OCT-2010, entry version 73. DE RecName: Full=Tastin; DE AltName: Full=Trophinin-assisting protein; DE AltName: Full=Trophinin-associated protein; GN Name=TROAP; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=95278733; PubMed=7758945; RA Fukuda M.N., Sato T., Nakayama J., Klier G., Mikami M., Aoki D., RA Nozawa S.; RT "Trophinin and tastin, a novel cell adhesion molecule complex with RT potential involvement in embryo implantation."; RL Genes Dev. 9:1199-1210(1995). RN [2] RP SEQUENCE REVISION TO 714 AND 742. RA Fukuda M., Sato T.; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lymph; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334; SER-344 AND RP SER-376, AND MASS SPECTROMETRY. RC TISSUE=Cervix carcinoma; RX PubMed=16964243; DOI=10.1038/nbt1240; RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; RT "A probability-based approach for high-throughput protein RT phosphorylation analysis and site localization."; RL Nat. Biotechnol. 24:1285-1292(2006). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170, AND MASS RP SPECTROMETRY. RC TISSUE=Cervix carcinoma; RX PubMed=19007248; DOI=10.1021/ac801708p; RA Wang B., Malik R., Nigg E.A., Korner R.; RT "Evaluation of the low-specificity protease elastase for large-scale RT phosphoproteome analysis."; RL Anal. Chem. 80:9526-9533(2008). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-271; SER-334 AND RP SER-376, AND MASS SPECTROMETRY. RC TISSUE=Cervix carcinoma; RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007; RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., RA Greff Z., Keri G., Stemmann O., Mann M.; RT "Kinase-selective enrichment enables quantitative phosphoproteomics of RT the kinome across the cell cycle."; RL Mol. Cell 31:438-448(2008). RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; THR-18; SER-98; RP SER-307; SER-324; SER-334; THR-358; SER-362 AND THR-363, AND MASS RP SPECTROMETRY. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334, AND MASS RP SPECTROMETRY. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). CC -!- FUNCTION: Could be involved with bystin and trophinin in a cell CC adhesion molecule complex that mediates an initial attachment of CC the blastocyst to uterine epithelial cells at the time of the CC embryo implantation. CC -!- SUBUNIT: Directly binds bystin, and indirectly trophinin. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- TISSUE SPECIFICITY: Strong expression at implantation sites. Was CC exclusively localized to the apical side of the CC syncytiotrophoblast. Also found in macrophages. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; U04810; AAA79333.2; -; mRNA. DR EMBL; CH471111; EAW58064.1; -; Genomic_DNA. DR EMBL; BC032583; AAH32583.1; -; mRNA. DR IPI; IPI00029680; -. DR PIR; I38487; I38487. DR RefSeq; NP_005471.3; -. DR UniGene; Hs.524399; -. DR ProteinModelPortal; Q12815; -. DR IntAct; Q12815; 3. DR STRING; Q12815; -. DR PRIDE; Q12815; -. DR Ensembl; ENST00000257909; ENSP00000257909; ENSG00000135451. DR GeneID; 10024; -. DR CTD; 10024; -. DR GeneCards; GC12P049716; -. DR H-InvDB; HIX0010602; -. DR HGNC; HGNC:12327; TROAP. DR MIM; 603872; gene. DR PharmGKB; PA37003; -. DR eggNOG; prNOG19177; -. DR HOVERGEN; HBG069140; -. DR InParanoid; Q12815; -. DR OMA; QLEVPEP; -. DR OrthoDB; EOG9X0QC5; -. DR PhylomeDB; Q12815; -. DR NextBio; 37877; -. DR ArrayExpress; Q12815; -. DR Bgee; Q12815; -. DR CleanEx; HS_TROAP; -. DR Genevestigator; Q12815; -. DR GermOnline; ENSG00000135451; Homo sapiens. DR GO; GO:0005737; C:cytoplasm; TAS:ProtInc. DR GO; GO:0007155; P:cell adhesion; TAS:ProtInc. PE 1: Evidence at protein level; KW Cell adhesion; Complete proteome; Cytoplasm; Phosphoprotein; Repeat. FT CHAIN 1 778 Tastin. FT /FTId=PRO_0000065636. FT REPEAT 516 548 1. FT REPEAT 549 581 2. FT REPEAT 582 614 3. FT REPEAT 615 647 4. FT REGION 516 647 4 X 33 AA approximate tandem repeats. FT COMPBIAS 504 687 Cys-rich. FT MOD_RES 16 16 Phosphoserine. FT MOD_RES 18 18 Phosphothreonine. FT MOD_RES 98 98 Phosphoserine. FT MOD_RES 170 170 Phosphoserine. FT MOD_RES 271 271 Phosphoserine. FT MOD_RES 307 307 Phosphoserine. FT MOD_RES 324 324 Phosphoserine. FT MOD_RES 334 334 Phosphoserine. FT MOD_RES 344 344 Phosphoserine. FT MOD_RES 358 358 Phosphothreonine. FT MOD_RES 362 362 Phosphoserine. FT MOD_RES 363 363 Phosphothreonine. FT MOD_RES 376 376 Phosphoserine. FT CONFLICT 224 224 R -> H (in Ref. 1; AAA79333). SQ SEQUENCE 778 AA; 83857 MW; 530B0481EC8D7E02 CRC64; MTTRQATKDP LLRGVSPTPS KIPVRSQKRT PFPTVTSCAV DQENQDPRRW VQKPPLNIQR PLVDSAGPRP KARHQAETSQ RLVGISQPRN PLEELRPSPR GQNVGPGPPA QTEAPGTIEF VADPAALATI LSGEGVKSCH LGRQPSLAKR VLVRGSQGGT TQRVQGVRAS AYLAPRTPTH RLDPARASCF SRLEGPGPRG RTLCPQRLQA LISPSGPSFH PSTRPSFQEL RRETAGSSRT SVSQASGLLL ETPVQPAFSL PKGEREVVTH SDEGGVASLG LAQRVPLREN REMSHTRDSH DSHLMPSPAP VAQPLPGHVV PCPSPFGRAQ RVPSPGPPTL TSYSVLRRLT VQPKTRFTPM PSTPRVQQAQ WLRGVSPQSC SEDPALPWEQ VAVRLFDQES CIRSLEGSGK PPVATPSGPH SNRTPSLQEV KIQRIGILQQ LLRQEVEGLV GGQCVPLNGG SSLDMVELQP LLTEISRTLN ATEHNSGTSH LPGLLKHSGL PKPCLPEECG EPQPCPPAEP GPPEAFCRSE PEIPEPSLQE QLEVPEPYPP AEPRPLESCC RSEPEIPESS RQEQLEVPEP CPPAEPRPLE SYCRIEPEIP ESSRQEQLEV PEPCPPAEPG PLQPSTQGQS GPPGPCPRVE LGASEPCTLE HRSLESSLPP CCSQWAPATT SLIFSSQHPL CASPPICSLQ SLRPPAGQAG LSNLAPRTLA LRERLKSCLT AIHCFHEARL DDECAFYTSR APPSGPTRVC TNPVATLLEW QDALCFIPVG SAAPQGSP //