ID TM55B_HUMAN Reviewed; 277 AA. AC Q86T03; B2RA35; Q86U09; Q8WUC0; Q9BU67; Q9NSU8; DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2003, sequence version 1. DT 05-OCT-2010, entry version 71. DE RecName: Full=Transmembrane protein 55B; DE EC=3.1.3.78; DE AltName: Full=PtdIns-4,5-P2 4-Ptase I; DE AltName: Full=Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase; GN Name=TMEM55B; Synonyms=C14orf9; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Neuroblastoma, and T-cell; RA Li W.B., Gruber C., Jessee J., Polayes D.; RT "Full-length cDNA libraries and normalization."; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Substantia nigra; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Testis; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Brain, and Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. RX PubMed=16365287; DOI=10.1073/pnas.0509740102; RA Ungewickell A., Hugge C., Kisseleva M., Chang S.-C., Zou J., Feng Y., RA Galyov E.E., Wilson M., Majerus P.W.; RT "The identification and characterization of two phosphatidylinositol- RT 4,5-bisphosphate 4-phosphatases."; RL Proc. Natl. Acad. Sci. U.S.A. 102:18854-18859(2005). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162, AND MASS RP SPECTROMETRY. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). CC -!- FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of CC phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze CC phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol CC 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- CC bisphosphate, phosphatidylinositol 5-monophosphate, CC phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- CC monophosphate. CC -!- CATALYTIC ACTIVITY: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + CC H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate. CC -!- CATALYTIC ACTIVITY: 1-phosphatidyl-1D-myo-inositol 4,5- CC bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate CC + phosphate. CC -!- SUBCELLULAR LOCATION: Late endosome membrane; Multi-pass membrane CC protein. Lysosome membrane; Multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q86T03-1; Sequence=Displayed; CC Name=2; CC IsoId=Q86T03-2; Sequence=VSP_007815; CC Note=No experimental confirmation available; CC Name=3; CC IsoId=Q86T03-3; Sequence=VSP_007816, VSP_007817; CC Note=May be due to intron retention.; CC -!- TISSUE SPECIFICITY: Ubiquitous. CC -!- SEQUENCE CAUTION: CC Sequence=CAB70896.1; Type=Erroneous initiation; CC Sequence=CAD62347.1; Type=Erroneous initiation; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; BX161490; CAD61939.1; -; mRNA. DR EMBL; BX248025; CAD62347.1; ALT_INIT; mRNA. DR EMBL; AK314021; BAG36732.1; -; mRNA. DR EMBL; AL137727; CAB70896.1; ALT_INIT; mRNA. DR EMBL; CH471078; EAW66461.1; -; Genomic_DNA. DR EMBL; BC002867; AAH02867.2; -; mRNA. DR EMBL; BC020947; AAH20947.1; -; mRNA. DR IPI; IPI00030530; -. DR IPI; IPI00332278; -. DR IPI; IPI00332279; -. DR PIR; T46382; T46382. DR RefSeq; NP_001094284.1; -. DR RefSeq; NP_653169.2; -. DR UniGene; Hs.7001; -. DR ProteinModelPortal; Q86T03; -. DR PhosphoSite; Q86T03; -. DR PRIDE; Q86T03; -. DR Ensembl; ENST00000250489; ENSP00000250489; ENSG00000165782. DR GeneID; 90809; -. DR KEGG; hsa:90809; -. DR UCSC; uc001vxk.2; human. DR UCSC; uc001vxl.2; human. DR CTD; 90809; -. DR GeneCards; GC14M020926; -. DR H-InvDB; HIX0011490; -. DR HGNC; HGNC:19299; TMEM55B. DR MIM; 609865; gene. DR PharmGKB; PA134919069; -. DR eggNOG; prNOG11235; -. DR HOVERGEN; HBG080409; -. DR OMA; GIYASWA; -. DR OrthoDB; EOG9S4S25; -. DR PhylomeDB; Q86T03; -. DR BioCyc; MetaCyc:ENSG00000165782-MONOMER; -. DR NextBio; 76969; -. DR ArrayExpress; Q86T03; -. DR Bgee; Q86T03; -. DR CleanEx; HS_TMEM55B; -. DR Genevestigator; Q86T03; -. DR GermOnline; ENSG00000165782; Homo sapiens. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR InterPro; IPR019178; Transmembrane_protein_55A/B. DR PANTHER; PTHR21014; Transmembrane_protein_55A/B; 1. DR Pfam; PF09788; Tmemb_55A; 1. PE 1: Evidence at protein level; KW Alternative splicing; Complete proteome; Endosome; Hydrolase; KW Lysosome; Membrane; Phosphoprotein; Transmembrane; KW Transmembrane helix. FT CHAIN 1 277 Transmembrane protein 55B. FT /FTId=PRO_0000072579. FT TRANSMEM 212 232 Helical; (Potential). FT TRANSMEM 242 262 Helical; (Potential). FT MOTIF 133 139 CX5R motif. FT COMPBIAS 17 37 Gly-rich. FT COMPBIAS 34 80 Pro-rich. FT ACT_SITE 133 133 By similarity. FT MOD_RES 162 162 Phosphoserine. FT VAR_SEQ 47 47 A -> AGKHAPPQ (in isoform 2). FT /FTId=VSP_007815. FT VAR_SEQ 48 224 AFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQ FT SLINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNC FT LLICKVTSQRIACPRPYCKRIINLGPVHPGPLSPEPQPMGV FT RVICGHCKNTFLWTEFTDRTLARCPHCRKVSSIGRRYPRKR FT CICCFLLGLLLAV -> GKHAPPQGKPGRVRGAPRGTLKAG FT EGAGPRAEAGPSRQVRDCCTCDWARLPSLRNRDHSLGTEGG FT SEQPDRSANYEKPSELGQRVEDQKDFPTTVEHQWGCK (in FT isoform 3). FT /FTId=VSP_007816. FT VAR_SEQ 225 277 Missing (in isoform 3). FT /FTId=VSP_007817. FT CONFLICT 208 208 P -> T (in Ref. 5; AAH20947). SQ SEQUENCE 277 AA; 29470 MW; A85FE1F736366CBC CRC64; MAADGERSPL LSEPIDGGAG GNGLVGPGGS GAGPGGGLTP SAPPYGAAFP PFPEGHPAVL PGEDPPPYSP LTSPDSGSAP MITCRVCQSL INVEGKMHQH VVKCGVCNEA TPIKNAPPGK KYVRCPCNCL LICKVTSQRI ACPRPYCKRI INLGPVHPGP LSPEPQPMGV RVICGHCKNT FLWTEFTDRT LARCPHCRKV SSIGRRYPRK RCICCFLLGL LLAVTATGLA FGTWKHARRY GGIYAAWAFV ILLAVLCLGR ALYWACMKVS HPVQNFS //