ID   SRFB1_HUMAN             Reviewed;         429 AA.
AC   Q8NEF9; Q5QFI2; Q96AH4; Q96DK2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   05-OCT-2010, entry version 61.
DE   RecName: Full=Serum response factor-binding protein 1;
DE   AltName: Full=SRF-dependent transcription regulation-associated protein;
DE   AltName: Full=p49/STRAP;
GN   Name=SRFBP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   TISSUE=Heart;
RX   PubMed=15492011; DOI=10.1074/jbc.M405945200;
RA   Zhang X., Azhar G., Zhong Y., Wei J.Y.;
RT   "Identification of a novel serum response factor cofactor in cardiac
RT   gene regulation.";
RL   J. Biol. Chem. 279:55626-55632(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastric mucosa;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Retinoblastoma, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; TYR-270; SER-273;
RP   SER-274; SER-276 AND SER-281, AND MASS SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA   Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in
RT   signaling networks.";
RL   Cell 127:635-648(2006).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; SER-274; SER-276;
RP   SER-279 AND SER-281, AND MASS SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- FUNCTION: May be involved in regulating transcriptional activation
CC       of cardiac genes during the aging process. May play a role in
CC       biosynthesis and/or processing of SLC2A4 in adipose cells (By
CC       similarity).
CC   -!- SUBUNIT: Interacts with SRF. Forms complexes with SRF and SRF
CC       cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus
CC       of SLC2A4 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region (By
CC       similarity).
CC   -!- TISSUE SPECIFICITY: Abundantly expressed in heart and skeletal
CC       muscle, and at much lower levels in brain and lung.
CC   -!- DEVELOPMENTAL STAGE: Up-regulated in adult heart (at protein
CC       level).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB71631.1; Type=Frameshift; Positions=425;
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DR   EMBL; AY611630; AAU25829.2; -; mRNA.
DR   EMBL; AK058015; BAB71631.1; ALT_FRAME; mRNA.
DR   EMBL; CH471086; EAW48900.1; -; Genomic_DNA.
DR   EMBL; BC017102; AAH17102.1; -; mRNA.
DR   EMBL; BC031222; AAH31222.1; -; mRNA.
DR   IPI; IPI00304493; -.
DR   RefSeq; NP_689759.2; -.
DR   UniGene; Hs.107622; -.
DR   ProteinModelPortal; Q8NEF9; -.
DR   STRING; Q8NEF9; -.
DR   PhosphoSite; Q8NEF9; -.
DR   PRIDE; Q8NEF9; -.
DR   Ensembl; ENST00000339397; ENSP00000341324; ENSG00000151304.
DR   GeneID; 153443; -.
DR   KEGG; hsa:153443; -.
DR   UCSC; uc003kst.1; human.
DR   CTD; 153443; -.
DR   GeneCards; GC05P121327; -.
DR   H-InvDB; HIX0005119; -.
DR   HGNC; HGNC:26333; SRFBP1.
DR   MIM; 610479; gene.
DR   PharmGKB; PA142670870; -.
DR   eggNOG; prNOG19354; -.
DR   HOGENOM; HBG714946; -.
DR   HOVERGEN; HBG056694; -.
DR   InParanoid; Q8NEF9; -.
DR   OMA; NIAVFQG; -.
DR   OrthoDB; EOG95HVHW; -.
DR   PhylomeDB; Q8NEF9; -.
DR   NextBio; 87112; -.
DR   ArrayExpress; Q8NEF9; -.
DR   Bgee; Q8NEF9; -.
DR   CleanEx; HS_SRFBP1; -.
DR   Genevestigator; Q8NEF9; -.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045449; P:regulation of transcription; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR015158; Bud-site_select_BUD22.
DR   Pfam; PF09073; BUD22; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein;
KW   Transcription; Transcription regulation.
FT   CHAIN         1    429       Serum response factor-binding protein 1.
FT                                /FTId=PRO_0000320006.
FT   COILED       42     67       Potential.
FT   COILED      108    146       Potential.
FT   MOD_RES     203    203       Phosphoserine.
FT   MOD_RES     270    270       Phosphotyrosine.
FT   MOD_RES     273    273       Phosphoserine.
FT   MOD_RES     274    274       Phosphoserine.
FT   MOD_RES     276    276       Phosphoserine.
FT   MOD_RES     279    279       Phosphoserine.
FT   MOD_RES     281    281       Phosphoserine.
FT   CONFLICT    345    345       F -> S (in Ref. 2; BAB71631).
SQ   SEQUENCE   429 AA;  48634 MW;  6046C3E73C87BCF0 CRC64;
     MAQPGTLNLN NEVVKMRKEV KRIRVLVIRK LVRSVGRLKS KKGTEDALLK NQRRAQRLLE
     EIHAMKELKP DIVTKSALGD DINFEKIFKK PDSTATERAI ARLAVHPLLK KKIDVLKAAV
     QAFKEARQNV AEVESSKNAS EDNHSENTLY SNDNGSNLQR EATVISEQKV KETKILAKKP
     IHNSKEKIAK MEHGPKAVTI ANSPSKPSEK DSVVSLESQK TPADPKLKTL SQTKKNKGSD
     SSLSGNSDGG EEFCEEEKEY FDDSTEERFY KQSSMSEDSD SGDDFFIGKV RRTRKKESSC
     HSSVKEQKPL EKVFLKEDTG ETHGDTRNDK IKPSTETRKL ESVFFHSLSG SKSSRRNFKE
     QAPKTRSLDF PQNEPQIKNQ FNKKLSGRLE NTKQQLQLPL HPSWEASRRR KEQQSNIAVF
     QGKKITFDD
//