ID   SP7_HUMAN               Reviewed;         431 AA.
AC   Q8TDD2; B3KY26; Q3MJ72;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   05-OCT-2010, entry version 66.
DE   RecName: Full=Transcription factor Sp7;
DE   AltName: Full=Zinc finger protein osterix;
GN   Name=SP7; Synonyms=OSX;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=21652532; PubMed=11792318; DOI=10.1016/S0092-8674(01)00622-5;
RA   Nakashima K., Zhou X., Kunkel G., Zhang Z., Deng J.M., Behringer R.R.,
RA   de Crombrugghe B.;
RT   "The novel zinc finger-containing transcription factor osterix is
RT   required for osteoblast differentiation and bone formation.";
RL   Cell 108:17-29(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14604442; DOI=10.1186/1471-2164-4-43;
RA   Milona M.-A., Gough J.E., Edgar A.J.;
RT   "Expression of alternatively spliced isoforms of human Sp7 in
RT   osteoblast-like cells.";
RL   BMC Genomics 4:43-43(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Osteosarcoma;
RX   PubMed=15474293; DOI=10.1016/j.gene.2004.05.026;
RA   Gao Y., Jheon A., Nourkeyhani H., Kobayashi H., Ganss B.;
RT   "Molecular cloning, structure, expression, and chromosomal
RT   localization of the human Osterix (SP7) gene.";
RL   Gene 341:101-110(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcriptional activator essential for osteoblast
CC       differentiation. Binds to SP1 and EKLF consensus sequences and to
CC       other G/C-rich sequences (By similarity).
CC   -!- SUBUNIT: Interacts with NO66/C14orf169; the interaction is direct
CC       and inhibits transcription activator activity (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- TISSUE SPECIFICITY: Restricted to bone-derived cell.
CC   -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
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DR   EMBL; AF466179; AAO33377.1; -; mRNA.
DR   EMBL; AY150673; AAN85556.1; -; mRNA.
DR   EMBL; AF477981; AAL84281.1; -; mRNA.
DR   EMBL; AK128520; BAG54688.1; -; mRNA.
DR   EMBL; CH471054; EAW96697.1; -; Genomic_DNA.
DR   EMBL; BC101549; AAI01550.1; -; mRNA.
DR   EMBL; BC113613; AAI13614.1; -; mRNA.
DR   IPI; IPI00152511; -.
DR   RefSeq; NP_001166938.1; -.
DR   RefSeq; NP_690599.1; -.
DR   UniGene; Hs.209402; -.
DR   ProteinModelPortal; Q8TDD2; -.
DR   SMR; Q8TDD2; 283-377.
DR   STRING; Q8TDD2; -.
DR   PRIDE; Q8TDD2; -.
DR   Ensembl; ENST00000303846; ENSP00000302812; ENSG00000170374.
DR   GeneID; 121340; -.
DR   UCSC; uc001sct.1; human.
DR   CTD; 121340; -.
DR   GeneCards; GC12M053721; -.
DR   H-InvDB; HIX0026350; -.
DR   HGNC; HGNC:17321; SP7.
DR   HPA; CAB005874; -.
DR   MIM; 606633; gene.
DR   PharmGKB; PA25072; -.
DR   eggNOG; prNOG09002; -.
DR   HOGENOM; HBG506364; -.
DR   HOVERGEN; HBG036899; -.
DR   InParanoid; Q8TDD2; -.
DR   OMA; DCLPSVY; -.
DR   OrthoDB; EOG986C07; -.
DR   NextBio; 80718; -.
DR   ArrayExpress; Q8TDD2; -.
DR   Bgee; Q8TDD2; -.
DR   CleanEx; HS_SP7; -.
DR   Genevestigator; Q8TDD2; -.
DR   GermOnline; ENSG00000170374; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   1: Evidence at protein level;
KW   Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    431       Transcription factor Sp7.
FT                                /FTId=PRO_0000047150.
FT   ZN_FING     294    318       C2H2-type 1.
FT   ZN_FING     324    348       C2H2-type 2.
FT   ZN_FING     354    376       C2H2-type 3.
SQ   SEQUENCE   431 AA;  44994 MW;  454A6FEA84309FF9 CRC64;
     MASSLLEEEV HYGSSPLAML TAACSKFGGS SPLRDSTTLG KAGTKKPYSV GSDLSASKTM
     GDAYPAPFTS TNGLLSPAGS PPAPTSGYAN DYPPFSHSFP GPTGTQDPGL LVPKGHSSSD
     CLPSVYTSLD MTHPYGSWYK AGIHAGISPG PGNTPTPWWD MHPGGNWLGG GQGQGDGLQG
     TLPTGPAQPP LNPQLPTYPS DFAPLNPAPY PAPHLLQPGP QHVLPQDVYK PKAVGNSGQL
     EGSGGAKPPR GASTGGSGGY GGSGAGRSSC DCPNCQELER LGAAAAGLRK KPIHSCHIPG
     CGKVYGKASH LKAHLRWHTG ERPFVCNWLF CGKRFTRSDE LERHVRTHTR EKKFTCLLCS
     KRFTRSDHLS KHQRTHGEPG PGPPPSGPKE LGEGRSTGEE EASQTPRPSA SPATPEKAPG
     GSPEQSNLLE I
//