ID   SP5_HUMAN               Reviewed;         398 AA.
AC   Q6BEB4;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   05-OCT-2010, entry version 59.
DE   RecName: Full=Transcription factor Sp5;
GN   Name=SP5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Takahashi M., Furukawa Y., Nakamura Y.;
RT   "Isolation of human Sp5 as a direct target of the b-catenin/T-cell
RT   factor 4 complex and its frequent elevated expression in colon
RT   cancers.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to GC boxes promoters elements. Probable
CC       transcriptional activator that has a role in the coordination of
CC       changes in transcription required to generate pattern in the
CC       developing embryo (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
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DR   EMBL; AB096175; BAD34944.1; -; mRNA.
DR   IPI; IPI00374189; -.
DR   RefSeq; NP_001003845.1; -.
DR   UniGene; Hs.368802; -.
DR   ProteinModelPortal; Q6BEB4; -.
DR   SMR; Q6BEB4; 285-380, 354-382.
DR   STRING; Q6BEB4; -.
DR   PRIDE; Q6BEB4; -.
DR   Ensembl; ENST00000375281; ENSP00000364430; ENSG00000204335.
DR   GeneID; 389058; -.
DR   KEGG; hsa:389058; -.
DR   UCSC; uc002uge.1; human.
DR   CTD; 389058; -.
DR   GeneCards; GC02P171571; -.
DR   HGNC; HGNC:14529; SP5.
DR   MIM; 609391; gene.
DR   PharmGKB; PA25070; -.
DR   eggNOG; prNOG13988; -.
DR   HOGENOM; HBG446684; -.
DR   HOVERGEN; HBG014797; -.
DR   InParanoid; Q6BEB4; -.
DR   OMA; CAGAPHA; -.
DR   OrthoDB; EOG98SKCM; -.
DR   NextBio; 102548; -.
DR   ArrayExpress; Q6BEB4; -.
DR   Bgee; Q6BEB4; -.
DR   CleanEx; HS_SP5; -.
DR   Genevestigator; Q6BEB4; -.
DR   GermOnline; ENSG00000204335; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045449; P:regulation of transcription; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 3.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Polymorphism; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    398       Transcription factor Sp5.
FT                                /FTId=PRO_0000047146.
FT   ZN_FING     296    320       C2H2-type 1.
FT   ZN_FING     326    350       C2H2-type 2.
FT   ZN_FING     356    378       C2H2-type 3.
FT   COMPBIAS    164    173       Poly-Pro.
FT   COMPBIAS    224    235       Poly-Ala.
FT   VARIANT      75     75       A -> T (in dbSNP:rs3749036).
FT                                /FTId=VAR_052713.
SQ   SEQUENCE   398 AA;  41964 MW;  BC2C27EE3ED499FA CRC64;
     MAAVAVLRND SLQAFLQDRT PSASPDLGKH SPLALLAATC SRIGQPGAAA PPDFLQVPYD
     PALGSPSRLF HPWTADMPAH SPGALPPPHP SLGLTPQKTH LQPSFGAAHE LPLTPPADPS
     YPYEFSPVKM LPSSMAALPA SCAPAYVPYA AQAALPPGYS NLLPPPPPPP PPPTCRQLSP
     NPAPDDLPWW SIPQAGAGPG ASGVPGSGLS GACAGAPHAP RFPASAAAAA AAAAALQRGL
     VLGPSDFAQY QSQIAALLQT KAPLAATARR CRRCRCPNCQ AAGGAPEAEP GKKKQHVCHV
     PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKSFTRS DELQRHLRTH TGEKRFACPE
     CGKRFMRSDH LAKHVKTHQN KKLKVAEAGV KREDARDL
//