ID   SOX11_HUMAN             Reviewed;         441 AA.
AC   P35716; Q4ZFV8;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   05-OCT-2010, entry version 87.
DE   RecName: Full=Transcription factor SOX-11;
GN   Name=SOX11;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Fetal brain;
RX   MEDLINE=96115609; PubMed=8666406; DOI=10.1006/geno.1995.9970;
RA   Jay P., Goze C., Marsollier C., Taviaux S., Hardelin J.-P.,
RA   Koopman P., Berta P.;
RT   "The human SOX11 gene: cloning, chromosomal assignment and tissue
RT   expression.";
RL   Genomics 29:541-545(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neuroepithelium;
RX   MEDLINE=20039622; PubMed=10574465; DOI=10.1093/dnares/6.5.357;
RA   Azuma T., Ao S., Saito Y., Yano K., Seki N., Wakao H., Masuho Y.,
RA   Muramatsu M.;
RT   "Human SOX11, an upregulated gene during the neural differentiation,
RT   has a long 3' untranslated region.";
RL   DNA Res. 6:357-360(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-115.
RX   MEDLINE=93324385; PubMed=8332506; DOI=10.1093/nar/21.12.2943;
RA   Goze C., Poulat F., Berta P.;
RT   "Partial cloning of SOX-11 and SOX-12, two new human SOX genes.";
RL   Nucleic Acids Res. 21:2943-2943(1993).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- FUNCTION: Probably important in the developing nervous system. May
CC       also have a role in tissue modeling during development.
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed mainly in the nervous system.
CC   -!- SIMILARITY: Contains 1 HMG box DNA-binding domain.
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DR   EMBL; U23752; AAB08518.1; -; mRNA.
DR   EMBL; AB028641; BAA88122.1; -; mRNA.
DR   EMBL; AC108025; AAX88930.1; -; Genomic_DNA.
DR   EMBL; X73038; CAA51519.1; -; Genomic_DNA.
DR   IPI; IPI00020435; -.
DR   PIR; G01758; G01758.
DR   PIR; S34118; S34118.
DR   RefSeq; NP_003099.1; -.
DR   UniGene; Hs.432638; -.
DR   ProteinModelPortal; P35716; -.
DR   SMR; P35716; 49-125.
DR   STRING; P35716; -.
DR   PhosphoSite; P35716; -.
DR   PRIDE; P35716; -.
DR   Ensembl; ENST00000322002; ENSP00000322568; ENSG00000176887.
DR   GeneID; 6664; -.
DR   KEGG; hsa:6664; -.
DR   UCSC; uc002qyj.1; human.
DR   CTD; 6664; -.
DR   GeneCards; GC02P005783; -.
DR   H-InvDB; HIX0029774; -.
DR   HGNC; HGNC:11191; SOX11.
DR   HPA; CAB009378; -.
DR   HPA; HPA000536; -.
DR   MIM; 600898; gene.
DR   PharmGKB; PA36028; -.
DR   eggNOG; prNOG13586; -.
DR   HOGENOM; HBG715977; -.
DR   HOVERGEN; HBG005040; -.
DR   InParanoid; P35716; -.
DR   OMA; REAMDTE; -.
DR   OrthoDB; EOG9KPWX6; -.
DR   NextBio; 25981; -.
DR   ArrayExpress; P35716; -.
DR   Bgee; P35716; -.
DR   CleanEx; HS_SOX11; -.
DR   Genevestigator; P35716; -.
DR   GermOnline; ENSG00000176887; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0008135; F:translation factor activity, nucleic acid b...; IDA:UniProtKB.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR000910; HMG_HMG1/HMG2.
DR   InterPro; IPR009071; HMG_superfamily.
DR   InterPro; IPR017386; SOX-12/11/4a.
DR   Gene3D; G3DSA:1.10.30.10; HMG-box; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   PIRSF; PIRSF038098; SOX-12/11/4a; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Developmental protein; Differentiation;
KW   DNA-binding; Neurogenesis; Nucleus; Phosphoprotein; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    441       Transcription factor SOX-11.
FT                                /FTId=PRO_0000048750.
FT   DNA_BIND     49    117       HMG box.
FT   COMPBIAS    144    148       Poly-Gly.
FT   COMPBIAS    207    214       Poly-Gly.
FT   COMPBIAS    223    233       Poly-Asp.
FT   COMPBIAS    338    354       Poly-Ser.
FT   MOD_RES     206    206       Phosphoserine.
FT   MOD_RES     278    278       Phosphoserine (By similarity).
SQ   SEQUENCE   441 AA;  46679 MW;  50567A654F503C63 CRC64;
     MVQQAESLEA ESNLPREALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS
     KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP
     RKKPKMDPSA KPSASQSPEK SAAGGGGGSA GGGAGGAKTS KGSSKKCGKL KAPAAAGAKA
     GAGKAAQSGD YGGAGDDYVL GSLRVSGSGG GGAGKTVKCV FLDEDDDDDD DDDELQLQIK
     QEPDEEDEEP PHQQLLQPPG QQPSQLLRRY NVAKVPASPT LSSSAESPEG ASLYDEVRAG
     ATSGAGGGSR LYYSFKNITK QHPPPLAQPA LSPASSRSVS TSSSSSSGSS SGSSGEDADD
     LMFDLSLNFS QSAHSASEQQ LGGGAAAGNL SLSLVDKDLD SFSEGSLGSH FEFPDYCTPE
     LSEMIAGDWL EANFSDLVFT Y
//