ID   SMD1_HUMAN              Reviewed;         119 AA.
AC   P62314; B5BTZ1; P13641;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   05-OCT-2010, entry version 80.
DE   RecName: Full=Small nuclear ribonucleoprotein Sm D1;
DE            Short=Sm-D1;
DE   AltName: Full=Sm-D autoantigen;
DE   AltName: Full=snRNP core protein D1;
GN   Name=SNRPD1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 1-11.
RC   TISSUE=Placenta;
RX   MEDLINE=88263041; PubMed=3260384; DOI=10.1073/pnas.85.13.4832;
RA   Rokeach L.A., Haselby J.A., Hoch S.O.;
RT   "Molecular cloning of a cDNA encoding the human Sm-D autoantigen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:4832-4836(1988).
RN   [2]
RP   SEQUENCE REVISION.
RA   Rokeach L.A.;
RL   Submitted (JUL-1988) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=89376817; PubMed=2528429;
RA   Renz M., Heim C., Braeunling O., Czichos A., Wieland C., Seelig H.P.;
RT   "Expression of the major human ribonucleoprotein (RNP) autoantigens in
RT   Escherichia coli and their use in an EIA for screening sera from
RT   patients with autoimmune diseases.";
RL   Clin. Chem. 35:1861-1863(1989).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=19054851; DOI=10.1038/nmeth.1273;
RA   Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R.,
RA   Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y.,
RA   Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.,
RA   Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H.,
RA   Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M.,
RA   Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T.,
RA   Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A.,
RA   Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K.,
RA   Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S.,
RA   Isogai T., Imai J., Watanabe S., Nomura N.;
RT   "Human protein factory for converting the transcriptome into an in
RT   vitro-expressed proteome.";
RL   Nat. Methods 5:1011-1017(2008).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   METHYLATION.
RX   MEDLINE=21614655; PubMed=11747828; DOI=10.1016/S0960-9822(01)00592-9;
RA   Meister G., Eggert C., Buehler D., Brahms H., Kambach C., Fischer U.;
RT   "Methylation of Sm proteins by a complex containing PRMT5 and the
RT   putative U snRNP assembly factor pICln.";
RL   Curr. Biol. 11:1990-1994(2001).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE
RP   SPLICEOSOMAL C COMPLEX.
RX   PubMed=11991638; DOI=10.1017/S1355838202021088;
RA   Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.;
RT   "Purification and characterization of native spliceosomes suitable for
RT   three-dimensional structural analysis.";
RL   RNA 8:426-439(2002).
RN   [10]
RP   METHYLATION, AND INTERACTION WITH PRMT5 AND PRMT7.
RX   PubMed=17709427; DOI=10.1083/jcb.200702147;
RA   Gonsalvez G.B., Tian L., Ospina J.K., Boisvert F.-M., Lamond A.I.,
RA   Matera A.G.;
RT   "Two distinct arginine methyltransferases are required for biogenesis
RT   of Sm-class ribonucleoproteins.";
RL   J. Cell Biol. 178:733-740(2007).
RN   [11]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RA   Colinge J., Superti-Furga G., Bennett K.L.;
RL   Submitted (OCT-2008) to UniProtKB.
RN   [12]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 2-81 IN COMPLEX WITH SNRPD2.
RX   MEDLINE=99148270; PubMed=10025403; DOI=10.1016/S0092-8674(00)80550-4;
RA   Kambach C., Walke S., Young R., Avis J.M., de la Fortelle E.,
RA   Raker V.A., Luehrmann R., Li J., Nagai K.;
RT   "Crystal structures of two Sm protein complexes and their implications
RT   for the assembly of the spliceosomal snRNPs.";
RL   Cell 96:375-387(1999).
CC   -!- FUNCTION: May act as a charged protein scaffold to promote snRNP
CC       assembly or strengthen snRNP-snRNP interactions through
CC       nonspecific electrostatic contacts with RNA.
CC   -!- SUBUNIT: Identified in the spliceosome C complex, at least
CC       composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23,
CC       DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1,
CC       GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK,
CC       HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1,
CC       PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B,
CC       PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2,
CC       SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2,
CC       SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2,
CC       SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8.
CC   -!- INTERACTION:
CC       O95777:NAA38; NbExp=1; IntAct=EBI-372177, EBI-347779;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- PTM: Methylated on arginine residues by PRMT5 and PRMT7;
CC       methylation is required for assembly and biogenesis of snRNPs.
CC   -!- MISCELLANEOUS: In the autoimmune disease systemic lupus
CC       erythematosus, antinuclear antibodies are developed with Sm
CC       specificity.
CC   -!- SIMILARITY: Belongs to the snRNP core protein family.
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DR   EMBL; J03798; AAA36620.1; -; mRNA.
DR   EMBL; L36188; AAA85339.1; -; Genomic_DNA.
DR   EMBL; L36182; AAA85339.1; JOINED; Genomic_DNA.
DR   EMBL; L36186; AAA85339.1; JOINED; Genomic_DNA.
DR   EMBL; L36187; AAA85339.1; JOINED; Genomic_DNA.
DR   EMBL; CR542239; CAG47035.1; -; mRNA.
DR   EMBL; AB451227; BAG70041.1; -; mRNA.
DR   EMBL; AB451350; BAG70164.1; -; mRNA.
DR   EMBL; CH471088; EAX01130.1; -; Genomic_DNA.
DR   EMBL; BC001721; AAH01721.1; -; mRNA.
DR   EMBL; BC072427; AAH72427.1; -; mRNA.
DR   IPI; IPI00302850; -.
DR   PIR; A94201; A27668.
DR   RefSeq; NP_008869.1; -.
DR   UniGene; Hs.464734; -.
DR   PDB; 1B34; X-ray; 2.50 A; A=1-119.
DR   PDB; 3CW1; X-ray; 5.49 A; B/M/N/O=1-119.
DR   PDBsum; 1B34; -.
DR   PDBsum; 3CW1; -.
DR   ProteinModelPortal; P62314; -.
DR   DIP; DIP-31207N; -.
DR   IntAct; P62314; 26.
DR   MINT; MINT-1530147; -.
DR   STRING; P62314; -.
DR   PhosphoSite; P62314; -.
DR   PeptideAtlas; P62314; -.
DR   PRIDE; P62314; -.
DR   Ensembl; ENST00000300413; ENSP00000300413; ENSG00000167088.
DR   GeneID; 6632; -.
DR   KEGG; hsa:6632; -.
DR   UCSC; uc002ktj.1; human.
DR   CTD; 6632; -.
DR   GeneCards; GC18P019192; -.
DR   H-InvDB; HIX0014358; -.
DR   HGNC; HGNC:11158; SNRPD1.
DR   MIM; 601063; gene.
DR   PharmGKB; PA35999; -.
DR   eggNOG; prNOG20677; -.
DR   HOGENOM; HBG749684; -.
DR   HOVERGEN; HBG061491; -.
DR   InParanoid; P62314; -.
DR   OMA; HETVNIE; -.
DR   PhylomeDB; P62314; -.
DR   Reactome; REACT_1675; mRNA Processing.
DR   Reactome; REACT_21257; Metabolism of RNA.
DR   Reactome; REACT_71; Gene Expression.
DR   NextBio; 25835; -.
DR   ArrayExpress; P62314; -.
DR   Bgee; P62314; -.
DR   CleanEx; HS_SNRPD1; -.
DR   Genevestigator; P62314; -.
DR   GermOnline; ENSG00000167088; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005654; C:nucleoplasm; EXP:Reactome.
DR   GO; GO:0030532; C:small nuclear ribonucleoprotein complex; TAS:ProtInc.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; TAS:ProtInc.
DR   GO; GO:0000387; P:spliceosomal snRNP assembly; EXP:Reactome.
DR   GO; GO:0000245; P:spliceosome assembly; TAS:ProtInc.
DR   InterPro; IPR001163; LSM_domain.
DR   InterPro; IPR006649; LSM_domain_euk/arc.
DR   InterPro; IPR010920; LSM_related_domain.
DR   Pfam; PF01423; LSM; 1.
DR   SMART; SM00651; Sm; 1.
DR   SUPFAM; SSF50182; Sm_like_riboprot; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Direct protein sequencing;
KW   Methylation; mRNA processing; mRNA splicing; Nucleus; Repeat;
KW   Ribonucleoprotein; Spliceosome.
FT   CHAIN         1    119       Small nuclear ribonucleoprotein Sm D1.
FT                                /FTId=PRO_0000122201.
FT   COMPBIAS     86    119       Arg/Lys-rich (basic).
FT   HELIX         3      8
FT   STRAND       14     19
FT   STRAND       24     32
FT   STRAND       38     46
FT   STRAND       53     60
FT   HELIX        62     64
FT   STRAND       65     69
FT   HELIX        76     79
SQ   SEQUENCE   119 AA;  13282 MW;  0C81C94BF98E0810 CRC64;
     MKLVRFLMKL SHETVTIELK NGTQVHGTIT GVDVSMNTHL KAVKMTLKNR EPVQLETLSI
     RGNNIRYFIL PDSLPLDTLL VDVEPKVKSK KREAVAGRGR GRGRGRGRGR GRGRGGPRR
//