ID   OTX1_HUMAN              Reviewed;         354 AA.
AC   P32242; Q53TG6;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   05-OCT-2010, entry version 100.
DE   RecName: Full=Homeobox protein OTX1;
DE   AltName: Full=Orthodenticle homolog 1;
GN   Name=OTX1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=93327763; PubMed=8101484;
RA   Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M.R.,
RA   Nigro V., Boncinelli E.;
RT   "A vertebrate gene related to orthodenticle contains a homeodomain of
RT   the bicoid class and demarcates anterior neuroectoderm in the
RT   gastrulating mouse embryo.";
RL   EMBO J. 12:2735-2747(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probably plays a role in the development of the brain
CC       and the sense organs. Can bind to the BCD target sequence (BTS):
CC       5'-TCTAATCCC-3'.
CC   -!- INTERACTION:
CC       Q99750:MDFI; NbExp=2; IntAct=EBI-740446, EBI-724076;
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- TISSUE SPECIFICITY: Expressed in brain.
CC   -!- DEVELOPMENTAL STAGE: Embryo.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
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DR   EMBL; AC009501; AAY24357.1; -; Genomic_DNA.
DR   EMBL; BC007621; AAH07621.1; -; mRNA.
DR   IPI; IPI00027682; -.
DR   PIR; S39406; S39406.
DR   RefSeq; NP_055377.1; -.
DR   UniGene; Hs.445340; -.
DR   ProteinModelPortal; P32242; -.
DR   SMR; P32242; 13-90, 39-108.
DR   IntAct; P32242; 5.
DR   MINT; MINT-1437362; -.
DR   STRING; P32242; -.
DR   PRIDE; P32242; -.
DR   Ensembl; ENST00000282549; ENSP00000282549; ENSG00000115507.
DR   Ensembl; ENST00000366671; ENSP00000355631; ENSG00000115507.
DR   GeneID; 5013; -.
DR   KEGG; hsa:5013; -.
DR   UCSC; uc002scd.1; human.
DR   CTD; 5013; -.
DR   GeneCards; GC02P063189; -.
DR   H-InvDB; HIX0002090; -.
DR   HGNC; HGNC:8521; OTX1.
DR   HPA; CAB012341; -.
DR   MIM; 600036; gene.
DR   PharmGKB; PA32848; -.
DR   eggNOG; prNOG07013; -.
DR   HOGENOM; HBG713848; -.
DR   HOVERGEN; HBG004028; -.
DR   InParanoid; P32242; -.
DR   OMA; SCMQRSV; -.
DR   OrthoDB; EOG9FR3B8; -.
DR   PhylomeDB; P32242; -.
DR   NextBio; 19298; -.
DR   ArrayExpress; P32242; -.
DR   Bgee; P32242; -.
DR   CleanEx; HS_OTX1; -.
DR   Genevestigator; P32242; -.
DR   GermOnline; ENSG00000115507; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity; NAS:UniProtKB.
DR   InterPro; IPR001356; Homeobox.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR009057; Homeodomain-like.
DR   InterPro; IPR012287; Homeodomain-rel.
DR   InterPro; IPR003026; Otx1_TF.
DR   InterPro; IPR003025; Otx_TF.
DR   InterPro; IPR013851; Otx_TF_C.
DR   Gene3D; G3DSA:1.10.10.60; Homeodomain-rel; 1.
DR   Pfam; PF00046; Homeobox; 1.
DR   Pfam; PF03529; TF_Otx; 1.
DR   PRINTS; PR01256; OTX1HOMEOBOX.
DR   PRINTS; PR01255; OTXHOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain_like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus.
FT   CHAIN         1    354       Homeobox protein OTX1.
FT                                /FTId=PRO_0000049207.
FT   DNA_BIND     38     97       Homeobox.
FT   COMPBIAS    275    301       His-rich.
SQ   SEQUENCE   354 AA;  37327 MW;  E32C1E47464BDDAA CRC64;
     MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL DVLEALFAKT
     RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG SGTKSRPAKK KSSPVRESSG
     SESSGQFTPP AVSSSASSSS SASSSSANPA AAAAAGLGGN PVAAASSLST PAASSIWSPA
     SISPGSAPAS VSVPEPLAAP SNTSCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPTPSS
     SYFGGVDCSS YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH
     HQGYGGSGLA FNSADCLDYK EPGAAAASSA WKLNFNSPDC LDYKDQASWR FQVL
//