ID   NRX3B_HUMAN             Reviewed;         637 AA.
AC   Q9HDB5; A8MPU5; B3KPM7; Q6NUR0; Q8IUD8;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 4.
DT   05-OCT-2010, entry version 78.
DE   RecName: Full=Neurexin-3-beta;
DE   AltName: Full=Neurexin III-beta;
DE   Flags: Precursor;
GN   Name=NRXN3; Synonyms=KIAA0743;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC   TISSUE=Heart;
RX   MEDLINE=22266830; PubMed=12379233; DOI=10.1016/S0006-291X(02)02403-8;
RA   Occhi G., Rampazzo A., Beffagna G., Antonio Danieli G.;
RT   "Identification and characterization of heart-specific splicing of
RT   human neurexin 3 mRNA (NRXN3).";
RL   Biochem. Biophys. Res. Commun. 298:151-155(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
RX   MEDLINE=21945268; PubMed=11944992; DOI=10.1006/geno.2002.6734;
RA   Rowen L., Young J., Birditt B., Kaur A., Madan A., Philipps D.L.,
RA   Qin S., Minx P., Wilson R.K., Hood L., Graveley B.R.;
RT   "Analysis of the human neurexin genes: alternative splicing and the
RT   generation of protein diversity.";
RL   Genomics 79:587-597(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Stomach;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22459283; PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA   Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in
RT   signaling networks.";
RL   Cell 127:635-648(2006).
RN   [9]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND MASS
RP   SPECTROMETRY.
RX   PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200;
RA   Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA   Mann M., Daub H.;
RT   "Large-scale proteomics analysis of the human kinome.";
RL   Mol. Cell. Proteomics 8:1751-1764(2009).
CC   -!- FUNCTION: Neuronal cell surface protein that may be involved in
CC       cell recognition and cell adhesion.
CC   -!- SUBUNIT: The cytoplasmic C-terminal region binds to CASK (By
CC       similarity). Binds to neuroligins NLGN1, NLGN2 and NLGN3 (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative promoter usage, Alternative splicing; Named isoforms=3;
CC         Comment=A number of isoforms, alpha-type (AC Q9Y4C0) and
CC         beta-type (shown here), are produced by alternative promoter
CC         usage. Beta-type isoforms differ from alpha-type isoforms in
CC         their N-terminus;
CC       Name=1;
CC         IsoId=Q9HDB5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9HDB5-2; Sequence=VSP_036465, VSP_036466;
CC         Note=Produced by alternative splicing;
CC       Name=3;
CC         IsoId=Q9HDB5-3; Sequence=VSP_035644, VSP_035646, VSP_035647;
CC         Note=Produced by alternative splicing. No experimental
CC         confirmation available;
CC   -!- SIMILARITY: Belongs to the neurexin family.
CC   -!- SIMILARITY: Contains 1 laminin G-like domain.
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DR   EMBL; AJ493127; CAD37989.1; -; mRNA.
DR   EMBL; AF123462; AAD13621.1; -; Genomic_DNA.
DR   EMBL; AK056530; BAG51739.1; -; mRNA.
DR   EMBL; AL833739; CAH56254.1; -; mRNA.
DR   EMBL; AC008056; AAF09143.1; -; Genomic_DNA.
DR   EMBL; AC012099; AAF15058.1; -; Genomic_DNA.
DR   EMBL; AC018514; AAF99808.1; -; Genomic_DNA.
DR   EMBL; CH471061; EAW81313.1; -; Genomic_DNA.
DR   EMBL; CH471061; EAW81315.1; -; Genomic_DNA.
DR   EMBL; BC059368; AAH59368.1; -; mRNA.
DR   EMBL; BC068469; AAH68469.1; -; mRNA.
DR   IPI; IPI00034558; -.
DR   IPI; IPI00419705; -.
DR   IPI; IPI00915413; -.
DR   RefSeq; NP_620426.2; -.
DR   UniGene; Hs.368307; -.
DR   ProteinModelPortal; Q9HDB5; -.
DR   STRING; Q9HDB5; -.
DR   Ensembl; ENST00000440563; ENSP00000412741; ENSG00000021645.
DR   GeneID; 9369; -.
DR   UCSC; uc001xuq.2; human.
DR   CTD; 9369; -.
DR   GeneCards; GC14P078871; -.
DR   HGNC; HGNC:8010; NRXN3.
DR   MIM; 600567; gene.
DR   PharmGKB; PA31788; -.
DR   HOVERGEN; HBG052670; -.
DR   ArrayExpress; Q9HDB5; -.
DR   Bgee; Q9HDB5; -.
DR   CleanEx; HS_NRXN3; -.
DR   Genevestigator; Q9HDB5; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   InterPro; IPR008985; ConA-like_lec_gl.
DR   InterPro; IPR013320; ConA-like_subgrp.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR012680; Laminin_G_2.
DR   InterPro; IPR003585; Neurexin-like.
DR   Gene3D; G3DSA:2.60.120.200; ConA_like_subgrp; 1.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   SMART; SM00294; 4.1m; 1.
DR   SMART; SM00282; LamG; 1.
DR   SUPFAM; SSF49899; ConA_like_lec_gl; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Alternative promoter usage; Alternative splicing; Cell adhesion;
KW   Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     35       By similarity.
FT   CHAIN        36    637       Neurexin-3-beta.
FT                                /FTId=PRO_0000019502.
FT   TOPO_DOM     36    562       Extracellular (Potential).
FT   TRANSMEM    563    583       Helical; (Potential).
FT   TOPO_DOM    584    637       Cytoplasmic (Potential).
FT   DOMAIN       85    255       Laminin G-like.
FT   MOD_RES      10     10       Phosphoserine.
FT   MOD_RES      74     74       Phosphoserine.
FT   CARBOHYD    184    184       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    252    252       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    296    296       N-linked (GlcNAc...) (Potential).
FT   VAR_SEQ     200    200       T -> TGNTDNERFQMVKQKIPFKYNRPVEEWLQEK (in
FT                                isoform 3).
FT                                /FTId=VSP_035644.
FT   VAR_SEQ     328    328       S -> ST (in isoform 2).
FT                                /FTId=VSP_036465.
FT   VAR_SEQ     329    537       TGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIE
FT                                TTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETF
FT                                DSNLPPTDDEDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWE
FT                                SKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPA
FT                                GKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFR
FT                                NVPT -> GRS (in isoform 2).
FT                                /FTId=VSP_036466.
FT   VAR_SEQ     329    367       TGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTI
FT                                -> GRSARSSNAARSLRAALTWTWRLTYTFTPIIFISCVVH
FT                                (in isoform 3).
FT                                /FTId=VSP_035646.
FT   VAR_SEQ     368    637       Missing (in isoform 3).
FT                                /FTId=VSP_035647.
SQ   SEQUENCE   637 AA;  69305 MW;  A0F100DA9D72A149 CRC64;
     MHLRIHARRS PPRRPAWTLG IWFLFWGCIV SSVWSSSNVA SSSSTSSSPG SHSQHEHHFH
     GSKHHSVPIS IYRSPVSLRG GHAGATYIFG KSGGLILYTW PANDRPSTRS DRLAVGFSTT
     VKDGILVRID SAPGLGDFLQ LHIEQGKIGV VFNIGTVDIS IKEERTPVND GKYHVVRFTR
     NGGNATLQVD NWPVNEHYPT GRQLTIFNTQ AQIAIGGKDK GRLFQGQLSG LYYDGLKVLN
     MAAENNPNIK INGSVRLVGE VPSILGTTQT TSMPPEMSTT VMETTTTMAT TTTRKNRSTA
     SIQPTSDDLV SSAECSSDDE DFVECEPSTG GELVIPLLVE DPLATPPIAT RAPSITLPPT
     FRPLLTIIET TKDSLSMTSE AGLPCLSDQG SDGCDDDGLV ISGYGSGETF DSNLPPTDDE
     DFYTTFSLVT DKSLSTSIFE GGYKAHAPKW ESKDFRPNKV SETSRTTTTS LSPELIRFTA
     SSSSGMVPKL PAGKMNNRDL KPQPDIVLLP LPTAYELDST KLKSPLITSP MFRNVPTANP
     TEPGIRRVPG ASEVIRESSS TTGMVVGIVA AAALCILILL YAMYKYRNRD EGSYQVDETR
     NYISNSAQSN GTLMKEKQQS SKSGHKKQKN KDREYYV
//