ID   MYF5_HUMAN              Reviewed;         255 AA.
AC   P13349; Q6ISR9;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   05-OCT-2010, entry version 90.
DE   RecName: Full=Myogenic factor 5;
DE            Short=Myf-5;
DE   AltName: Full=Class C basic helix-loop-helix protein 2;
DE            Short=bHLHc2;
GN   Name=MYF5; Synonyms=BHLHC2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skeletal muscle;
RX   MEDLINE=89251600; PubMed=2721498;
RA   Braun T., Buschhausen-Denker G., Bober E., Tannich E., Arnold H.H.;
RT   "A novel human muscle factor related to but distinct from MyoD1
RT   induces myogenic conversion in 10T1/2 fibroblasts.";
RL   EMBO J. 8:701-709(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.
RA   Thompson D.B.;
RL   Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in muscle differentiation (myogenic factor).
CC       Induces fibroblasts to differentiate into myoblasts. Probable
CC       sequence specific DNA-binding protein.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another
CC       bHLH protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain.
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DR   EMBL; X14894; CAA33025.1; -; mRNA.
DR   EMBL; CH471054; EAW97368.1; -; Genomic_DNA.
DR   EMBL; BC069373; AAH69373.1; -; mRNA.
DR   EMBL; U27313; AAA69824.1; -; Genomic_DNA.
DR   IPI; IPI00008389; -.
DR   PIR; S04105; S04105.
DR   RefSeq; NP_005584.2; -.
DR   UniGene; Hs.178023; -.
DR   ProteinModelPortal; P13349; -.
DR   SMR; P13349; 76-140.
DR   STRING; P13349; -.
DR   PhosphoSite; P13349; -.
DR   PRIDE; P13349; -.
DR   Ensembl; ENST00000228644; ENSP00000228644; ENSG00000111049.
DR   GeneID; 4617; -.
DR   KEGG; hsa:4617; -.
DR   CTD; 4617; -.
DR   GeneCards; GC12P081085; -.
DR   HGNC; HGNC:7565; MYF5.
DR   MIM; 159990; gene.
DR   PharmGKB; PA31363; -.
DR   eggNOG; prNOG04680; -.
DR   HOGENOM; HBG714454; -.
DR   HOVERGEN; HBG006429; -.
DR   InParanoid; P13349; -.
DR   OMA; MMDGCQF; -.
DR   OrthoDB; EOG9PRW9K; -.
DR   PhylomeDB; P13349; -.
DR   Reactome; REACT_21303; Myogenesis.
DR   NextBio; 17772; -.
DR   ArrayExpress; P13349; -.
DR   Bgee; P13349; -.
DR   CleanEx; HS_MYF5; -.
DR   Genevestigator; P13349; -.
DR   GermOnline; ENSG00000111049; Homo sapiens.
DR   GO; GO:0005654; C:nucleoplasm; EXP:Reactome.
DR   GO; GO:0003705; F:RNA polymerase II transcription factor acti...; TAS:ProtInc.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007519; P:skeletal muscle tissue development; TAS:ProtInc.
DR   InterPro; IPR002546; Basic.
DR   InterPro; IPR011598; HLH_DNA-bd.
DR   InterPro; IPR001092; HLH_DNA-bd_dom.
DR   InterPro; IPR022032; Myf5.
DR   Gene3D; G3DSA:4.10.280.10; HLH_DNA_bd; 1.
DR   Pfam; PF01586; Basic; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF12232; Myf5; 1.
DR   SMART; SM00520; BASIC; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; HLH_basic; 1.
DR   PROSITE; PS50888; HLH; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Developmental protein; Differentiation;
KW   DNA-binding; Myogenesis; Nucleus.
FT   CHAIN         1    255       Myogenic factor 5.
FT                                /FTId=PRO_0000127344.
FT   DOMAIN       96    135       Helix-loop-helix motif.
FT   DNA_BIND     83     95       Basic motif.
FT   CONFLICT    241    241       A -> R (in Ref. 1; CAA33025).
SQ   SEQUENCE   255 AA;  28296 MW;  62F00454C729BE66 CRC64;
     MDVMDGCQFS PSEYFYDGSC IPSPEGEFGD EFVPRVAAFG AHKAELQGSD EDEHVRAPTG
     HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN QAFETLKRCT TTNPNQRLPK
     VEILRNAIRY IESLQELLRE QVENYYSLPG QSCSEPTSPT SNCSDGMPEC NSPVWSRKSS
     TFDSIYCPDV SNVYATDKNS LSSLDCLSNI VDRITSSEQP GLPLQDLASL SPVASTDSQP
     ATPGASSSRL IYHVL
//