ID MXRA5_HUMAN Reviewed; 2828 AA. AC Q9NR99; Q6P1M7; Q9Y3Y8; DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 31-OCT-2006, sequence version 2. DT 05-OCT-2010, entry version 70. DE RecName: Full=Matrix-remodeling-associated protein 5; DE AltName: Full=Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan; DE Short=Adlican; DE Flags: Precursor; GN Name=MXRA5; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT VAL-2531. RC TISSUE=Placenta; RA Crowl R.M., Luk D.; RT "Identification of the gene encoding adlican, a novel protein RT expressed in human arthritic tissues."; RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE. RX PubMed=15609104; DOI=10.1007/s10522-004-3188-1; RA Chondrogianni N., Simoes D.C.M., Franceschi C., Gonos E.S.; RT "Cloning of differentially expressed genes in skin fibroblasts from RT centenarians."; RL Biogerontology 5:401-409(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-739, AND VARIANT VAL-2531. RC TISSUE=Muscle; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2245-2828. RC TISSUE=Brain; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). CC -!- SUBCELLULAR LOCATION: Secreted (Potential). CC -!- DEVELOPMENTAL STAGE: Over-expressed in centenarians. Expression is CC reduced from young to old but increased from old to centenarians. CC -!- SIMILARITY: Contains 12 Ig-like C2-type (immunoglobulin-like) CC domains. CC -!- SIMILARITY: Contains 7 LRR (leucine-rich) repeats. CC -!- SEQUENCE CAUTION: CC Sequence=AAH11846.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; CC Sequence=AAH64986.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; CC Sequence=AAH80586.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF245505; AAF86402.1; -; mRNA. DR EMBL; BC011846; AAH11846.1; ALT_SEQ; mRNA. DR EMBL; BC064986; AAH64986.1; ALT_SEQ; mRNA. DR EMBL; BC080586; AAH80586.1; ALT_SEQ; mRNA. DR EMBL; AL049946; CAB43220.1; -; mRNA. DR IPI; IPI00012347; -. DR PIR; T08678; T08678. DR RefSeq; NP_056234.2; -. DR UniGene; Hs.369422; -. DR HSSP; Q9BZR6; 1OZN. DR ProteinModelPortal; Q9NR99; -. DR IntAct; Q9NR99; 1. DR STRING; Q9NR99; -. DR PRIDE; Q9NR99; -. DR Ensembl; ENST00000217939; ENSP00000217939; ENSG00000101825. DR Ensembl; ENST00000381114; ENSP00000370505; ENSG00000101825. DR GeneID; 25878; -. DR KEGG; hsa:25878; -. DR UCSC; uc004crg.2; human. DR CTD; 25878; -. DR GeneCards; GC0XM003220; -. DR H-InvDB; HIX0016637; -. DR HGNC; HGNC:7539; MXRA5. DR HPA; HPA000508; -. DR PharmGKB; PA31340; -. DR eggNOG; prNOG06981; -. DR HOGENOM; HBG278515; -. DR InParanoid; Q9NR99; -. DR NextBio; 47288; -. DR ArrayExpress; Q9NR99; -. DR Bgee; Q9NR99; -. DR CleanEx; HS_MXRA5; -. DR Genevestigator; Q9NR99; -. DR GermOnline; ENSG00000101825; Homo sapiens. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR000372; LRR-contain_N. DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 12. DR Pfam; PF07679; I-set; 11. DR SMART; SM00409; IG; 2. DR SMART; SM00408; IGc2; 10. DR SMART; SM00369; LRR_TYP; 3. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00013; LRRNT; 1. DR PROSITE; PS50835; IG_LIKE; 12. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; Leucine-rich repeat; KW Polymorphism; Repeat; Secreted; Signal. FT SIGNAL 1 26 Potential. FT CHAIN 27 2828 Matrix-remodeling-associated protein 5. FT /FTId=PRO_0000254131. FT REPEAT 54 77 LRR 1. FT REPEAT 78 101 LRR 2. FT REPEAT 103 125 LRR 3. FT REPEAT 126 149 LRR 4. FT REPEAT 151 173 LRR 5. FT REPEAT 182 205 LRR 6. FT DOMAIN 481 571 Ig-like C2-type 1. FT DOMAIN 575 669 Ig-like C2-type 2. FT REPEAT 1410 1434 LRR 7. FT DOMAIN 1853 1946 Ig-like C2-type 3. FT DOMAIN 1950 2041 Ig-like C2-type 4. FT DOMAIN 2046 2140 Ig-like C2-type 5. FT DOMAIN 2146 2239 Ig-like C2-type 6. FT DOMAIN 2242 2343 Ig-like C2-type 7. FT DOMAIN 2345 2432 Ig-like C2-type 8. FT DOMAIN 2440 2534 Ig-like C2-type 9. FT DOMAIN 2542 2630 Ig-like C2-type 10. FT DOMAIN 2637 2722 Ig-like C2-type 11. FT DOMAIN 2733 2828 Ig-like C2-type 12. FT CARBOHYD 287 287 N-linked (GlcNAc...) (Potential). FT CARBOHYD 321 321 N-linked (GlcNAc...) (Potential). FT CARBOHYD 633 633 N-linked (GlcNAc...) (Potential). FT CARBOHYD 1403 1403 N-linked (GlcNAc...) (Potential). FT CARBOHYD 1735 1735 N-linked (GlcNAc...) (Potential). FT CARBOHYD 2007 2007 N-linked (GlcNAc...) (Potential). FT CARBOHYD 2056 2056 N-linked (GlcNAc...) (Potential). FT CARBOHYD 2693 2693 N-linked (GlcNAc...) (Potential). FT DISULFID 501 555 By similarity. FT DISULFID 599 651 By similarity. FT DISULFID 1875 1928 By similarity. FT DISULFID 1972 2025 By similarity. FT DISULFID 2069 2122 By similarity. FT DISULFID 2168 2221 By similarity. FT DISULFID 2265 2324 By similarity. FT DISULFID 2368 2418 By similarity. FT DISULFID 2466 2518 By similarity. FT DISULFID 2564 2616 By similarity. FT DISULFID 2659 2711 By similarity. FT DISULFID 2755 2810 By similarity. FT VARIANT 764 764 V -> L (in dbSNP:rs5983120). FT /FTId=VAR_056057. FT VARIANT 824 824 V -> I (in dbSNP:rs5983119). FT /FTId=VAR_060357. FT VARIANT 1128 1128 V -> A (in dbSNP:rs1635246). FT /FTId=VAR_060358. FT VARIANT 1394 1394 D -> G (in dbSNP:rs1726199). FT /FTId=VAR_060359. FT VARIANT 1484 1484 T -> A (in dbSNP:rs12396910). FT /FTId=VAR_056058. FT VARIANT 1665 1665 P -> S (in dbSNP:rs1974522). FT /FTId=VAR_056059. FT VARIANT 2000 2000 S -> G (in dbSNP:rs1635242). FT /FTId=VAR_060360. FT VARIANT 2531 2531 L -> V (in dbSNP:rs1726208). FT /FTId=VAR_028821. FT CONFLICT 55 55 K -> R (in Ref. 1; AAF86402). FT CONFLICT 2245 2245 I -> V (in Ref. 4; CAB43220). FT CONFLICT 2353 2353 Y -> C (in Ref. 4; CAB43220). FT CONFLICT 2640 2640 N -> S (in Ref. 4; CAB43220). SQ SEQUENCE 2828 AA; 312280 MW; 1B92E64566E2F5E4 CRC64; MPKRAHWGAL SVVLILLWGH PRVALACPHP CACYVPSEVH CTFRSLASVP AGIAKHVERI NLGFNSIQAL SETSFAGLTK LELLMIHGNE IPSIPDGALR DLSSLQVFKF SYNKLRVITG QTLQGLSNLM RLHIDHNKIE FIHPQAFNGL TSLRLLHLEG NLLHQLHPST FSTFTFLDYF RLSTIRHLYL AENMVRTLPA SMLRNMPLLE NLYLQGNPWT CDCEMRWFLE WDAKSRGILK CKKDKAYEGG QLCAMCFSPK KLYKHEIHKL KDMTCLKPSI ESPLRQNRSR SIEEEQEQEE DGGSQLILEK FQLPQWSISL NMTDEHGNMV NLVCDIKKPM DVYKIHLNQT DPPDIDINAT VALDFECPMT RENYEKLWKL IAYYSEVPVK LHRELMLSKD PRVSYQYRQD ADEEALYYTG VRAQILAEPE WVMQPSIDIQ LNRRQSTAKK VLLSYYTQYS QTISTKDTRQ ARGRSWVMIE PSGAVQRDQT VLEGGPCQLS CNVKASESPS IFWVLPDGSI LKAPMDDPDS KFSILSSGWL RIKSMEPSDS GLYQCIAQVR DEMDRMVYRV LVQSPSTQPA EKDTVTIGKN PGESVTLPCN ALAIPEAHLS WILPNRRIIN DLANTSHVYM LPNGTLSIPK VQVSDSGYYR CVAVNQQGAD HFTVGITVTK KGSGLPSKRG RRPGAKALSR VREDIVEDEG GSGMGDEENT SRRLLHPKDQ EVFLKTKDDA INGDKKAKKG RRKLKLWKHS EKEPETNVAE GRRVFESRRR INMANKQINP ERWADILAKV RGKNLPKGTE VPPLIKTTSP PSLSLEVTPP FPAVSPPSAS PVQTVTSAEE SSADVPLLGE EEHVLGTISS ASMGLEHNHN GVILVEPEVT STPLEEVVDD LSEKTEEITS TEGDLKGTAA PTLISEPYEP SPTLHTLDTV YEKPTHEETA TEGWSAADVG SSPEPTSSEY EPPLDAVSLA ESEPMQYFDP DLETKSQPDE DKMKEDTFAH LTPTPTIWVN DSSTSQLFED STIGEPGVPG QSHLQGLTDN IHLVKSSLST QDTLLIKKGM KEMSQTLQGG NMLEGDPTHS RSSESEGQES KSITLPDSTL GIMSSMSPVK KPAETTVGTL LDKDTTTVTT TPRQKVAPSS TMSTHPSRRR PNGRRRLRPN KFRHRHKQTP PTTFAPSETF STQPTQAPDI KISSQVESSL VPTAWVDNTV NTPKQLEMEK NAEPTSKGTP RRKHGKRPNK HRYTPSTVSS RASGSKPSPS PENKHRNIVT PSSETILLPR TVSLKTEGPY DSLDYMTTTR KIYSSYPKVQ ETLPVTYKPT SDGKEIKDDV ATNVDKHKSD ILVTGESITN AIPTSRSLVS TMGEFKEESS PVGFPGTPTW NPSRTAQPGR LQTDIPVTTS GENLTDPPLL KELEDVDFTS EFLSSLTVST PFHQEEAGSS TTLSSIKVEV ASSQAETTTL DQDHLETTVA ILLSETRPQN HTPTAARMKE PASSSPSTIL MSLGQTTTTK PALPSPRISQ ASRDSKENVF LNYVGNPETE ATPVNNEGTQ HMSGPNELST PSSDRDAFNL STKLELEKQV FGSRSLPRGP DSQRQDGRVH ASHQLTRVPA KPILPTATVR LPEMSTQSAS RYFVTSQSPR HWTNKPEITT YPSGALPENK QFTTPRLSST TIPLPLHMSK PSIPSKFTDR RTDQFNGYSK VFGNNNIPEA RNPVGKPPSP RIPHYSNGRL PFFTNKTLSF PQLGVTRRPQ IPTSPAPVMR ERKVIPGSYN RIHSHSTFHL DFGPPAPPLL HTPQTTGSPS TNLQNIPMVS STQSSISFIT SSVQSSGSFH QSSSKFFAGG PPASKFWSLG EKPQILTKSP QTVSVTAETD TVFPCEATGK PKPFVTWTKV STGALMTPNT RIQRFEVLKN GTLVIRKVQV QDRGQYMCTA SNLHGLDRMV VLLSVTVQQP QILASHYQDV TVYLGDTIAM ECLAKGTPAP QISWIFPDRR VWQTVSPVES RITLHENRTL SIKEASFSDR GVYKCVASNA AGADSLAIRL HVAALPPVIH QEKLENISLP PGLSIHIHCT AKAAPLPSVR WVLGDGTQIR PSQFLHGNLF VFPNGTLYIR NLAPKDSGRY ECVAANLVGS ARRTVQLNVQ RAAANARITG TSPRRTDVRY GGTLKLDCSA SGDPWPRILW RLPSKRMIDA LFSFDSRIKV FANGTLVVKS VTDKDAGDYL CVARNKVGDD YVVLKVDVVM KPAKIEHKEE NDHKVFYGGD LKVDCVATGL PNPEISWSLP DGSLVNSFMQ SDDSGGRTKR YVVFNNGTLY FNEVGMREEG DYTCFAENQV GKDEMRVRVK VVTAPATIRN KTYLAVQVPY GDVVTVACEA KGEPMPKVTW LSPTNKVIPT SSEKYQIYQD GTLLIQKAQR SDSGNYTCLV RNSAGEDRKT VWIHVNVQPP KINGNPNPIT TVREIAAGGS RKLIDCKAEG IPTPRVLWAF PEGVVLPAPY YGNRITVHGN GSLDIRSLRK SDSVQLVCMA RNEGGEARLI LQLTVLEPME KPIFHDPISE KITAMAGHTI SLNCSAAGTP TPSLVWVLPN GTDLQSGQQL QRFYHKADGM LHISGLSSVD AGAYRCVARN AAGHTERLVS LKVGLKPEAN KQYHNLVSII NGETLKLPCT PPGAGQGRFS WTLPNGMHLE GPQTLGRVSL LDNGTLTVRE ASVFDRGTYV CRMETEYGPS VTSIPVIVIA YPPRITSEPT PVIYTRPGNT VKLNCMAMGI PKADITWELP DKSHLKAGVQ ARLYGNRFLH PQGSLTIQHA TQRDAGFYKC MAKNILGSDS KTTYIHVF //