ID   MTR1L_HUMAN             Reviewed;         617 AA.
AC   Q13585; Q0VGG3; Q3ZAR0;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   05-OCT-2010, entry version 78.
DE   RecName: Full=Melatonin-related receptor;
DE   AltName: Full=G protein-coupled receptor 50;
DE   AltName: Full=H9;
GN   Name=GPR50;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS 502-THR--HIS-505 DEL; ALA-532
RP   AND VAL-606.
RC   TISSUE=Pituitary;
RX   MEDLINE=96228068; PubMed=8647286; DOI=10.1016/0014-5793(96)00437-1;
RA   Reppert S.M., Weaver D.R., Ebisawa T., Mahle C.D.,
RA   Kolakowski L.F. Jr.;
RT   "Cloning of a melatonin-related receptor from human pituitary.";
RL   FEBS Lett. 386:219-224(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS 502-THR--HIS-505 DEL AND
RP   ALA-532.
RC   TISSUE=Pituitary;
RA   Kaighin V.A., Martin A.L., Aronstam R.S.;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS 502-THR--HIS-505
RP   DEL; ALA-532 AND VAL-606.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   SUBUNIT.
RX   PubMed=16778767; DOI=10.1038/sj.emboj.7601193;
RA   Levoye A., Dam J., Ayoub M.A., Guillaume J.L., Couturier C.,
RA   Delagrange P., Jockers R.;
RT   "The orphan GPR50 receptor specifically inhibits MT1 melatonin
RT   receptor function through heterodimerization.";
RL   EMBO J. 25:3012-3023(2006).
RN   [5]
RP   VARIANTS 502THR--HIS505 DEL; ALA-528 AND ILE-606.
RX   PubMed=16436372; DOI=10.1194/jlr.M500338-JLR200;
RA   Bhattacharyya S., Luan J., Challis B., Keogh J., Montague C.,
RA   Brennand J., Morten J., Lowenbeim S., Jenkins S., Farooqi I.S.,
RA   Wareham N.J., O'Rahilly S.;
RT   "Sequence variants in the melatonin-related receptor gene (GPR50)
RT   associate with circulating triglyceride and HDL levels.";
RL   J. Lipid Res. 47:761-766(2006).
CC   -!- FUNCTION: Does not bind melatonin.
CC   -!- SUBUNIT: Homodimer, and heterodimer with MTNR1A and MTNR1B.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Hypothalamus and pituitary.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR   EMBL; U52219; AAC50614.1; -; mRNA.
DR   EMBL; EU432118; ABY87917.1; -; mRNA.
DR   EMBL; BC103696; AAI03697.1; -; mRNA.
DR   EMBL; BC105683; AAI05684.1; -; mRNA.
DR   EMBL; BC105684; AAI05685.1; -; mRNA.
DR   IPI; IPI00299062; -.
DR   PIR; S70520; S70520.
DR   RefSeq; NP_004215.2; -.
DR   UniGene; Hs.567390; -.
DR   ProteinModelPortal; Q13585; -.
DR   SMR; Q13585; 30-313.
DR   MINT; MINT-2836359; -.
DR   STRING; Q13585; -.
DR   Ensembl; ENST00000218316; ENSP00000218316; ENSG00000102195.
DR   GeneID; 9248; -.
DR   KEGG; hsa:9248; -.
DR   CTD; 9248; -.
DR   GeneCards; GC0XP150345; -.
DR   H-InvDB; HIX0056195; -.
DR   H-InvDB; HIX0056463; -.
DR   HGNC; HGNC:4506; GPR50.
DR   MIM; 300207; gene.
DR   PharmGKB; PA28895; -.
DR   HOVERGEN; HBG052529; -.
DR   InParanoid; Q13585; -.
DR   ArrayExpress; Q13585; -.
DR   Bgee; Q13585; -.
DR   CleanEx; HS_GPR50; -.
DR   Genevestigator; Q13585; -.
DR   GermOnline; ENSG00000102195; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR   GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   InterPro; IPR002280; Mel_rcpt_1X.
DR   InterPro; IPR000025; Melatonin_rcpt.
DR   PANTHER; PTHR19264:SF65; Mel_rcpt_1X; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01151; MELATONIN1XR.
DR   PRINTS; PR00857; MELATONINR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Membrane; Polymorphism; Receptor;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN         1    617       Melatonin-related receptor.
FT                                /FTId=PRO_0000069878.
FT   TOPO_DOM      1     30       Extracellular (Potential).
FT   TRANSMEM     31     51       Helical; Name=1; (Potential).
FT   TOPO_DOM     52     64       Cytoplasmic (Potential).
FT   TRANSMEM     65     85       Helical; Name=2; (Potential).
FT   TOPO_DOM     86    103       Extracellular (Potential).
FT   TRANSMEM    104    124       Helical; Name=3; (Potential).
FT   TOPO_DOM    125    143       Cytoplasmic (Potential).
FT   TRANSMEM    144    164       Helical; Name=4; (Potential).
FT   TOPO_DOM    165    188       Extracellular (Potential).
FT   TRANSMEM    189    209       Helical; Name=5; (Potential).
FT   TOPO_DOM    210    239       Cytoplasmic (Potential).
FT   TRANSMEM    240    260       Helical; Name=6; (Potential).
FT   TOPO_DOM    261    273       Extracellular (Potential).
FT   TRANSMEM    274    294       Helical; Name=7; (Potential).
FT   TOPO_DOM    295    617       Cytoplasmic (Potential).
FT   COMPBIAS    315    612       Pro-rich.
FT   DISULFID    101    178       By similarity.
FT   VARIANT     502    505       Missing (lower fasting circulating
FT                                triglyceride levels).
FT                                /FTId=VAR_062254.
FT   VARIANT     532    532       T -> A (higher fasting circulating
FT                                triglyceride levels; dbSNP:rs561077).
FT                                /FTId=VAR_062255.
FT   VARIANT     606    606       I -> V (higher fasting circulating
FT                                triglyceride levels; dbSNP:rs13440581).
FT                                /FTId=VAR_062256.
FT   CONFLICT    320    320       S -> P (in Ref. 1; AAC50614).
FT   CONFLICT    448    448       A -> G (in Ref. 1; AAC50614).
SQ   SEQUENCE   617 AA;  67369 MW;  A0B73A7ACE1053BB CRC64;
     MGPTLAVPTP YGCIGCKLPQ PEYPPALIIF MFCAMVITIV VDLIGNSMVI LAVTKNKKLR
     NSGNIFVVSL SVADMLVAIY PYPLMLHAMS IGGWDLSQLQ CQMVGFITGL SVVGSIFNIV
     AIAINRYCYI CHSLQYERIF SVRNTCIYLV ITWIMTVLAV LPNMYIGTIE YDPRTYTCIF
     NYLNNPVFTV TIVCIHFVLP LLIVGFCYVR IWTKVLAARD PAGQNPDNQL AEVRNFLTMF
     VIFLLFAVCW CPINVLTVLV AVSPKEMAGK IPNWLYLAAY FIAYFNSCLN AVIYGLLNEN
     FRREYWTIFH AMRHPIIFFS GLISDIREMQ EARTLARARA HARDQAREQD RAHACPAVEE
     TPMNVRNVPL PGDAAAGHPD RASGHPKPHS RSSSAYRKSA STHHKSVFSH SKAASGHLKP
     VSGHSKPASG HPKSATVYPK PASVHFKADS VHFKGDSVHF KPDSVHFKPA SSNPKPITGH
     HVSAGSHSKS AFSAATSHPK PTTGHIKPAT SHAEPTTADY PKPATTSHPK PTAADNPELS
     ASHCPEIPAI AHPVSDDSDL PESASSPAAG PTKPAASQLE SDTIADLPDP TVVTTSTNDY
     HDVVVIDVED DPDEMAV
//