ID   H1T_HUMAN               Reviewed;         207 AA.
AC   P22492; Q6ISI1; Q8IUE8;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 4.
DT   05-OCT-2010, entry version 92.
DE   RecName: Full=Histone H1t;
DE   AltName: Full=Testicular H1 histone;
GN   Name=HIST1H1T; Synonyms=H1FT, H1T;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LEU-14.
RX   MEDLINE=91365256; PubMed=1889752; DOI=10.1016/0378-1119(91)90284-I;
RA   Drabent B., Kardalinou E., Doenecke D.;
RT   "Structure and expression of the human gene encoding testicular H1
RT   histone (H1t).";
RL   Gene 103:263-268(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LYS-178.
RX   MEDLINE=94230585; PubMed=8175896; DOI=10.1002/jcb.240540210;
RA   Koppel D.A., Wolfe S.A., Fogelfeld L., Grimes S.R.;
RT   "Primate testicular histone H1t genes are highly conserved and the
RT   human H1t gene is located on chromosome 6.";
RL   J. Cell. Biochem. 54:219-230(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=22296985; PubMed=12408966; DOI=10.1016/S0888-7543(02)96850-3;
RA   Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J.;
RT   "The human and mouse replication-dependent histone genes.";
RL   Genomics 80:487-498(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-159 AND THR-160, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA   Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in
RT   signaling networks.";
RL   Cell 127:635-648(2006).
CC   -!- FUNCTION: Histones H1 are necessary for the condensation of
CC       nucleosome chains into higher order structures.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- DEVELOPMENTAL STAGE: This histone is a testis-specific H1 variant
CC       that appears during meiosis in spermatogenesis.
CC   -!- SIMILARITY: Belongs to the histone H1/H5 family.
CC   -!- SIMILARITY: Contains 1 H15 (linker histone H1/H5 globular) domain.
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DR   EMBL; M60094; AAA35944.1; -; Genomic_DNA.
DR   EMBL; M97755; AAA19936.1; -; Genomic_DNA.
DR   EMBL; AF531301; AAN06701.1; -; Genomic_DNA.
DR   EMBL; BC069517; AAH69517.2; -; mRNA.
DR   IPI; IPI00419983; -.
DR   PIR; JH0550; JH0550.
DR   RefSeq; NP_005314.2; -.
DR   UniGene; Hs.533293; -.
DR   ProteinModelPortal; P22492; -.
DR   SMR; P22492; 43-113.
DR   IntAct; P22492; 1.
DR   STRING; P22492; -.
DR   PhosphoSite; P22492; -.
DR   PRIDE; P22492; -.
DR   Ensembl; ENST00000338379; ENSP00000341214; ENSG00000187475.
DR   GeneID; 3010; -.
DR   KEGG; hsa:3010; -.
DR   UCSC; uc003ngj.1; human.
DR   CTD; 3010; -.
DR   GeneCards; GC06M026165; -.
DR   HGNC; HGNC:4720; HIST1H1T.
DR   MIM; 142712; gene.
DR   PharmGKB; PA29098; -.
DR   HOGENOM; HBG446956; -.
DR   HOVERGEN; HBG009035; -.
DR   InParanoid; P22492; -.
DR   OMA; QERVGMS; -.
DR   OrthoDB; EOG90KBK4; -.
DR   PhylomeDB; P22492; -.
DR   NextBio; 11936; -.
DR   ArrayExpress; P22492; -.
DR   Bgee; P22492; -.
DR   CleanEx; HS_HIST1H1T; -.
DR   Genevestigator; P22492; -.
DR   GermOnline; ENSG00000187475; Homo sapiens.
DR   GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
DR   InterPro; IPR005818; Histone_H1/H5.
DR   InterPro; IPR005819; Histone_H5.
DR   InterPro; IPR011991; WHTH_trsnscrt_rep_DNA-bd.
DR   Gene3D; G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.
DR   Pfam; PF00538; Linker_histone; 1.
DR   PRINTS; PR00624; HISTONEH5.
DR   SMART; SM00526; H15; 1.
DR   PROSITE; PS51504; H15; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Chromosome; Complete proteome; Developmental protein;
KW   Differentiation; DNA-binding; Nucleus; Phosphoprotein; Polymorphism;
KW   Spermatogenesis.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    207       Histone H1t.
FT                                /FTId=PRO_0000195910.
FT   DOMAIN       40    113       H15.
FT   MOD_RES       2      2       N-acetylserine (By similarity).
FT   MOD_RES     159    159       Phosphothreonine.
FT   MOD_RES     160    160       Phosphothreonine.
FT   VARIANT      14     14       V -> L (in dbSNP:rs198844).
FT                                /FTId=VAR_049310.
FT   VARIANT      52     52       L -> F (in dbSNP:rs2051542).
FT                                /FTId=VAR_049311.
FT   VARIANT     178    178       Q -> K (in dbSNP:rs198845).
FT                                /FTId=VAR_049312.
SQ   SEQUENCE   207 AA;  22019 MW;  9CF27B275DA29B48 CRC64;
     MSETVPAASA SAGVAAMEKL PTKKRGRKPA GLISASRKVP NLSVSKLITE ALSVSQERVG
     MSLVALKKAL AAAGYDVEKN NSRIKLSLKS LVNKGILVQT RGTGASGSFK LSKKVIPKST
     RSKAKKSVSA KTKKLVLSRD SKSPKTAKTN KRAKKPRATT PKTVRSGRKA KGAKGKQQQK
     SPVKARASKS KLTQHHEVNV RKATSKK
//