ID   GPR1_HUMAN              Reviewed;         355 AA.
AC   P46091; A5JUU6; A8K4L1; Q53TR9; Q6NVX4;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 2.
DT   05-OCT-2010, entry version 88.
DE   RecName: Full=Probable G-protein coupled receptor 1;
GN   Name=GPR1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=95154831; PubMed=7851889; DOI=10.1006/geno.1994.1549;
RA   Marchese A., Docherty J.M., Nguyen T., Heiber M., Cheng R.,
RA   Heng H.H.Q., Tsui L.-C., Shi X., George S.R., O'Dowd B.F.;
RT   "Cloning of human genes encoding novel G protein-coupled receptors.";
RL   Genomics 23:609-618(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hippocampus;
RA   Martin A.L., Kaighin V.A., Aronstam R.S.;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-307.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-307.
RC   TISSUE=Placenta;
RX   PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA   Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA   Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA   Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA   Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA   Isogai T.;
RT   "Signal sequence and keyword trap in silico for selection of full-
RT   length human cDNAs encoding secretion or membrane proteins from oligo-
RT   capped cDNA libraries.";
RL   DNA Res. 12:117-126(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-307.
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   CHARACTERIZATION OF ITS HIV-1 CORECEPTOR FUNCTION.
RX   PubMed=10233994;
RA   Shimizu N., Soda Y., Kanbe K., Liu H.Y., Jinno A., Kitamura T.,
RA   Hoshino H.;
RT   "An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to
RT   allow replication of human immunodeficiency virus types 1 and 2 in
RT   brain-derived cells.";
RL   J. Virol. 73:5231-5239(1999).
CC   -!- FUNCTION: Orphan receptor. Probable opioid receptor. Can act as a
CC       coreceptor for HIV-1.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in hippocampus.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR   EMBL; U13666; AAA64592.1; -; Genomic_DNA.
DR   EMBL; EF577403; ABQ52423.1; -; mRNA.
DR   EMBL; AK290976; BAF83665.1; -; mRNA.
DR   EMBL; AK075130; BAG52070.1; -; mRNA.
DR   EMBL; AC007383; AAY15063.1; -; Genomic_DNA.
DR   EMBL; CH471063; EAW70383.1; -; Genomic_DNA.
DR   EMBL; BC067833; AAH67833.1; -; mRNA.
DR   IPI; IPI00004345; -.
DR   PIR; A55733; A55733.
DR   RefSeq; NP_001091669.1; -.
DR   RefSeq; NP_005270.2; -.
DR   UniGene; Hs.184907; -.
DR   ProteinModelPortal; P46091; -.
DR   SMR; P46091; 40-319.
DR   STRING; P46091; -.
DR   Ensembl; ENST00000358706; ENSP00000351541; ENSG00000183671.
DR   Ensembl; ENST00000407325; ENSP00000384345; ENSG00000183671.
DR   Ensembl; ENST00000437420; ENSP00000397535; ENSG00000183671.
DR   GeneID; 2825; -.
DR   KEGG; hsa:2825; -.
DR   UCSC; uc002vbl.2; human.
DR   CTD; 2825; -.
DR   GeneCards; GC02M207003; -.
DR   HGNC; HGNC:4463; GPR1.
DR   HPA; HPA010525; -.
DR   MIM; 600239; gene.
DR   PharmGKB; PA28846; -.
DR   eggNOG; prNOG09515; -.
DR   HOGENOM; HBG715940; -.
DR   HOVERGEN; HBG107927; -.
DR   InParanoid; P46091; -.
DR   OMA; FKWKKTV; -.
DR   OrthoDB; EOG9QFZZV; -.
DR   PhylomeDB; P46091; -.
DR   NextBio; 11145; -.
DR   ArrayExpress; P46091; -.
DR   Bgee; P46091; -.
DR   CleanEx; HS_GPR1; -.
DR   Genevestigator; P46091; -.
DR   GermOnline; ENSG00000183671; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   InterPro; IPR002275; GPR1_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01146; GPR1ORPHANR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism;
KW   Receptor; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN         1    355       Probable G-protein coupled receptor 1.
FT                                /FTId=PRO_0000069505.
FT   TOPO_DOM      1     41       Extracellular (Potential).
FT   TRANSMEM     42     62       Helical; Name=1; (Potential).
FT   TOPO_DOM     63     73       Cytoplasmic (Potential).
FT   TRANSMEM     74     94       Helical; Name=2; (Potential).
FT   TOPO_DOM     95    112       Extracellular (Potential).
FT   TRANSMEM    113    133       Helical; Name=3; (Potential).
FT   TOPO_DOM    134    154       Cytoplasmic (Potential).
FT   TRANSMEM    155    175       Helical; Name=4; (Potential).
FT   TOPO_DOM    176    210       Extracellular (Potential).
FT   TRANSMEM    211    231       Helical; Name=5; (Potential).
FT   TOPO_DOM    232    247       Cytoplasmic (Potential).
FT   TRANSMEM    248    268       Helical; Name=6; (Potential).
FT   TOPO_DOM    269    286       Extracellular (Potential).
FT   TRANSMEM    287    307       Helical; Name=7; (Potential).
FT   TOPO_DOM    308    355       Cytoplasmic (Potential).
FT   CARBOHYD     14     14       N-linked (GlcNAc...) (Potential).
FT   DISULFID    110    187       By similarity.
FT   VARIANT     307    307       I -> V (in dbSNP:rs3732083).
FT                                /FTId=VAR_023839.
FT   CONFLICT     65     65       F -> L (in Ref. 1; AAA64592).
FT   CONFLICT    237    238       SI -> TV (in Ref. 1; AAA64592).
SQ   SEQUENCE   355 AA;  41431 MW;  E25D54CBA59F9C8F CRC64;
     MEDLEETLFE EFENYSYDLD YYSLESDLEE KVQLGVVHWV SLVLYCLAFV LGIPGNAIVI
     WFTGFKWKKT VTTLWFLNLA IADFIFLLFL PLYISYVAMN FHWPFGIWLC KANSFTAQLN
     MFASVFFLTV ISLDHYIHLI HPVLSHRHRT LKNSLIVIIF IWLLASLIGG PALYFRDTVE
     FNNHTLCYNN FQKHDPDLTL IRHHVLTWVK FIIGYLFPLL TMSICYLCLI FKVKKRSILI
     SSRHFWTILV VVVAFVVCWT PYHLFSIWEL TIHHNSYSHH VMQAGIPLST GLAFLNSCLN
     PILYVLISKK FQARFRSSVA EILKYTLWEV SCSGTVSEQL RNSETKNLCL LETAQ
//